اثر کوتاه مدت مکمل کوئرستین برشاخص های التهابی و استرس اکسیداتیو افراد فعال پس از فعالیت ورزشی شدید

نوع مقاله : مقاله پژوهشی Released under CC BY 4.0 license I Open Access I

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران

2 استاد فیزولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه اصفهان، اصفهان، ایران.

10.22049/jahssp.2021.27237.1351

چکیده

هدف : کوئرستین یکی از فلاونوئیدهای(Flavonoids) مهم موجود در بیش از بیست ماده گیاهی است که به عنوان مکمل ضدالتهابی شناخته شده است. به همین دلیل نیز، کوئرستین به عنوان یک مکمل طبیعی مورد توجه ورزشکاران قرار گرفته است. هدف از پژوهش حاضر ارزیابی اثر کوتاه مدت دریافت مکمل کوئرستین بر شاخص­های التهابی و استرس اکسیداتیو افراد فعال است. روش شناسی:  در یک مطالعه نیمه تجربی، تعداد 25 دانشجوی دختر فعال با دامنه­ی سنی 24- 18 سال بطور داوطلبانه انتخاب و سپس بصورت تصادفی در دو گروه افراد فعال همراه با دریافت مکمل کوئرستین(AQ) و گروه افراد فعال با دریافت دارونما(AP) قرار گرفتند. گروه  AQ، 500 میلی­گرم مکمل کوئرستین و گروه AP، 500 میلی­گرم دارونما، 5/1 ساعت قبل از آزمون دریافت نمودند. هر دوگروه فعالیت ورزشی شدید را براساس پروتکل بروس قبل و بعد از مصرف مکمل کوئرستین اجرا کردند. سطوح شاخص­های التهابی اینترلوکین­8(IL-8) و استرس اکسیداتیو 8­ایزوپرستان(8-IsoP) قبل و در پایان مداخله اندازه­گیری شد. داده­ها با استفاده از آزمون­های آماری tوابسته و آنالیزکوواریانس با کنترل پیش­آزمون در سطح کمتر از 05/0 تجزیه و تحلیل شد. یافته­ها: پس از مداخله، اگر چه سطوح IL-8 و 8-IsoP در گروه AQ در پس­آزمون نسبت به پیش­آزمون کاهش داشت، اما این کاهش تنها در میزان IL-8 معنی­دار بود(05/0 >p). نتایج نیز کاهش معنی­داری در سطوح IL-8 و 8-IsoP گروه AQ در مقایسه با گروه AP در پس آزمون نشان داد(05/0 >p). نتیجه گیری: نتایج حاصل از این مطالعه نشان داد که مکمل کوئرستین در کاهش التهاب و استرس اکسیداتیو پس از فعالیت ورزشی شدید موثر است.

کلیدواژه‌ها


عنوان مقاله [English]

Short-term effect of Quercetin supplementation on inflammatory and oxidative stress indices of active individuals after intense exercise

نویسندگان [English]

  • Safa Jabbari 1
  • Mehdi Kargarfard 2
1 Master of Sports Physiology, Faculty of Sports Sciences, University of Isfahan, Isfahan, Iran
2 Professor of Sports Physiology, Faculty of Sports Sciences, University of Isfahan, Isfahan, Iran.
چکیده [English]

Aim:   Quercetin is one of the important bioflavonoids present in more than twenty plants material and which is known as an anti-inflammatory supplement. For this reason, quercetin is considered by athletes as a natural supplement. The aim of this study was to evaluate the short-term effect of quercetin supplementation on inflammatory and oxidative stress indices in active individuals. Methods:  In a semi-experimental study, 25 female active students aged 18-24 years voluntarily were selected and then randomly divided into two groups: active subjects receiving quercetin supplementation (AQ) and active subjects receiving placebo (AP). The AQ group received 500 mg of quercetin supplementation and the AP group received 500 mg of placebo 1.5 hours before the test. Both groups performed strenuous exercise according to the Bruce protocol before and after taking Quercetin supplementation. The levels of Interleukin8 (IL-8) and 8-Isoprostane (8-IsoP) indices were measured before and at the end of intervention. Data were analyzed using dependent t-test and analysis of covariance with pretest control at a level less than 0.05.   Results:  After the intervention, although the levels of IL-8 and 8-IsoP decreased in the post-test compared to the pretest in the AQ group, but this decrease was only significant in the level of IL-8(p <0.05).The resultsalso showed a significant decrease in IL-8 and 8-IsoP levels of AQ group compared to AP group in post-test(p <0.05).  Conclusion:  The results of this study showed that quercetin supplementation is effective in reducing inflammation and oxidative stress after strenuous exercise.

کلیدواژه‌ها [English]

  • Quercetin supplement
  • Interleukin-8
  • 8-Isoprostane
  • Intense exercise
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دوره 8، شماره 1
فروردین 1400
صفحه 36-43
  • تاریخ دریافت: 09 اردیبهشت 1400
  • تاریخ بازنگری: 10 خرداد 1400
  • تاریخ پذیرش: 14 خرداد 1400
  • تاریخ اولین انتشار: 14 خرداد 1400