اثرشش هفته تمرینات استقامتی، مقاومتی و ترکیبی بر آنزیم‌های کبدی( ALT و AST ) در رت‌های اوریکتومی شده

نوع مقاله: مقاله پژوهشی

نویسندگان

دانشجوی دکتری فیزیولوژی ورزشی، گروه فیزولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه تهران، تهران ایران.

چکیده

مقدمه و هدف: بیماری کبد چرب، نوعی تجمع چربی در سلول های کبدی است که در صورت عدم کنترل،روندی بدخیم را به سمت فیبروز شدن بافت کبد و تخریب سلولی آن طی می کند. در این مطالعه تأثیر تمرینات استقامتی، مقاومتی و بر آنزیم‌های کبدی در رت‌های اوریکتومی شده مورد بررسی قرار گرفت. مواد و روشها: بدین منظور50 سر موش صحرایی ماده نژاد ویستار تحت شرایط کنترل شده )دما، چرخۀ روشنایی و تاریکی و دسترسی آزاد به آب و غذا(نگهداری شدند و بعد از آشناسازی با پروتکل تمرینی، به صورت تصادفی به 5 گروه 10 تایی شامل: گروه شم(Sham) ، گروه اواریکتومی( (OVX ، گروه اواریکتومی شده و تمرین مقاومتی (OVX+RE) ، گروه اواریکتومی شده و تمرین استقامتی (OVX+EN) ، گروه اواریکتومی شده و ترکیب تمرینات استقامتی-مقاومتی (OVX+EN+RE) تقسیم شدند. 48 ساعت پس از پایان آخرین جلسۀ تمرینی حیوانات بیهوش و تشریح شدند وبافت کبد برای بررسی آنزیم های مربوطه از بدن جدا شد. نتایج:نتایج نشان داد که تمرینات استقامتی و مقاومتی وترکیبی برآنزیم های کبدی ALT و AST در رت‌های اوریکتومی شده تأثیر معناداری دارد (05/0 p<). ولی تمرینات ترکیبی بیشترین تاثیر را برآنزیم کبدی ALT و AST در رت‌های اوریکتومی داشت (05/0 p<). اواریکتومی باعث افزایش آنزیم های کبدی ALT و AST شد (05/0 p≤)

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Effect of six weeks endurance, resistance and combined training on liver ALT and AST in the liver of ovariectomized rat

نویسندگان [English]

  • Morteza jourkesh
  • Habib Ebadi
PhD Student of Sport Physiology, Department of Sport Physiology, Faculty of Physical Education, University of Tehran, Tehran Iran.
چکیده [English]

Background and Objective: Fatty liver disease is a kind of fat accumulation in the liver cells which uncontrolled subjects have a trend to parenchymal fibrosis and cell death. In this study, we investigated the effects the combined Resistance-Endurance training and Soybean supplementation on expression of Mir-133 in the heart ovariectomized (OVX) rats. Materials and methods: Fifty wistar female rats under controlled conditions (temperature, light/dark (12:12) cycle, with ad Libitum access to food and water) were housed and after familiarization with protocol they were divided into five groups, ten per group: Sham, Ovariectomy (OVX), OVX with Soy (OVX+SOY), OVX with Resistance-Endurance training (OVX+RE+EN) and OVX+RE+EN with Soy (OVX+ RE+EN+SOY). 48 hours after the end of the last session rats were anesthetized and sacrificed.Results:The results showed that endurance and resistance training and combination of Endurance- Resistance training had a significant effect on ALT and AST liver enzymes in orectomized rats (p <0.05) Combined exercises had the greatest effect on ALT and AST liver enzymes in OVX rats (p <0.05)

کلیدواژه‌ها [English]

  • Exercise training
  • Ovariectomy
  • AST
  • ALT
  • Liver
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