اثر هشت هفته تمرین پیلاتس بر سطوح سرمی فاکتور رشد فیبرو بلاست 21 (FGF21)، شاخص مقاومت به انسولین و پروفایل لیپیدی زنان مبتلا به کبد چرب غیر الکلی

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران

2 هیات علمی/دانشگاه شهید مدنی آذربایجان

3 مرکز تحقیقات غدد درون ریز، دانشگاه علوم پزشکی تبریز: تبریز، ایران.

10.22049/jahssp.2024.29350.1622

چکیده

هدف: بیماری کبد چرب غیر الکلی یکی از شایعترین بیماری‌‌های مزمن کبدی در سرتاسر جهان است. هدف این پژوهش، بررسی اثر یک دوره تمرین پیلاتس بر سطوح سرمی فاکتور رشد فیبرو بلاست 21 ، شاخص مقاومت به انسولین و پروفایل لیپیدی در زنان مبتلا به کبد چرب غیر الکلی بود.
 روش شناسی: تعداد 30 زن مبتلا به NAFLD با گرید 2 به صورت هدفنمد انتخاب و به طور تصادفی در دو گروه تجربی (15 نفر) و شاهد (15 نفر) قرار گرفتند. گروه تمرین در یک برنامه تمرینی هشت هفته ای پیلاتس که هر هفته شامل  سه جلسه در هفته و هر جلسه یک ساعت به طول انجامید، شرکت کردند، درحالی که گروه شاهد در مدت پژوهش روش زندگی معمول خود را حفظ و دنبال کردند. نمونه‌‌‌های خونی در مراحل پیش و پس آزمون بعد از 12 ساعت ناشتایی جمع آوری شد. جهت تحلیل داده ها، از آزمون t وابسته برای بررسی تغییرات درون‌گروهی و از آزمون آنکوا (ANCOVA) با کوواریانت قرار دادن مقادیر پایه برای بررسی تغییرات بین­گروهی استفاده شد. تمام تحلیل‌‌‌‌های آماری با استفاده از نرم‌افزار SPSS 23 انجام ‌شد و سطح معنی داری نیز 05/0P ≤  در نظر گرفته شد. یافته‌ها: در اثر مداخله تمرین در گروه تجربی در مقایسه با گروه شاهد، سطوح سرمی FGF21 (001/0=p)، لیپوپروتئین با چگالی بالا (HDL-C) (001/0=p) افزایش معنادار و مقادیر شاخص مقاومت به انسولین (001/0=p)، تری گلیسیرید(001/0=p) ، کلسترول(001/0=p)، شاخص توده بدن (001/0=p) و درصد چربی بدن(017/0=p)،  کاهش معنی داری داشتند.
نتیجه‌گیری: با توجه به اثرات مثبت تمرین پیلاتس مورد استفاده در این مطالعه بر مقادیر FGF21 و متغیر‌‌های پروفایل لیپیدی و ترکیب بدنی در آزمودنی‌‌‌های مورد مطالعه، می‌‌توان این نوع تمرین را بعنوان یک مداخله درمانی غیرداروئی برای بهبود وضعیت بیماران مبتلا به NAFLD پیشنهاد نمود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of eight weeks of Pilates exercise on serum levels of fibroblast growth factor 21 (FGF21), insulin resistance index and lipid profile in women with non-alcoholic fatty liver disease

نویسندگان [English]

  • Sahar Taran 1
  • bahloul ghorbanian 2
  • Helda Tutunchi 3
1 Department of physical education, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
2 professor assistant/azarbaijan shahid madani university
3 Department of endocrine Research Center, Tabriz University of Medical Sciences: Tabriz, , Iran.
چکیده [English]

Aim: Non-alcoholic fatty liver disease is one of the most common chronic liver diseases worldwide. The aim of this study was to investigate the effect of a course of Pilates exercises on serum levels of fibroblast growth factor 21, insulin resistance index and lipid profile in women with non-alcoholic fatty liver disease. Methods:   30 women with grade 2 NAFLD were purposefully selected and randomly divided into two experimental (n=15) and control (n=15) groups. The exercise group participated in an eight-week Pilates training program that consisted of three sessions per week, each session lasting one hour, while the control group maintained and followed their usual way of life during the research period. Blood samples were collected in pre-test and post-test phases after 12 hours of fasting. To analyze the data, the dependent t-test was used to examine intra-group changes and the ANCOVA test with the covariate of baseline values was used to examine inter-group changes.  All statistical analyzes were performed using SPSS23 software, and the significance level was considered P ≤ 0.05. Results: As a result of exercise intervention in the experimental group compared to the control group, serum levels of FGF21 (p=0.001), high-density lipoprotein (HDL-C) (p=0.001), significantly increased and the values of insulin resistance index (p=0.001), triglyceride (p=0.001), cholesterol (p=0.001), body mass index (p=0.001) and body fat percentage (p=0.017), significantly were decreased.
Conclusions: Considering the positive effects of Pilates exercise used in this study on FGF21 levels and lipid profile variables and body composition in the studied subjects, this type of exercise can be suggested as a non-pharmacological treatment intervention to improve the condition of patients with NAFLD.

کلیدواژه‌ها [English]

  • Pilates exercise
  • FGF21
  • insulin resistance index
  • lipid profile
  • non-alcoholic fatty liver

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