تاثیر تمرینات پیلاتس و هوازی بر سطح سرمی سیرتوئین-1، مهارکننده فعال کننده پلاسمینوژن-1 و شاخص مقاومت به انسولین در زنان مبتلا به دیابت نوع دو

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد واحد بجنورد، بجنورد، ایران

2 دانشگاه صنعتی بیرجند

3 دانشگاه ازاد بجنورد

4 دانشگاه ازاد اسلامی واحد بجنورد

5 دانشجوی دکتری فیزیولوژی ورزشی- دانشگاه ازاد اسلامی واحد بجنورد

10.22049/jahssp.2024.29241.1610

چکیده

هدف: دیابت سبب بروز طیف گسترده‎ای از مشکلات جدی سلامتی در انسان می‌شود. سیرتوئین‌-1 و مهارکننده فعال کننده پلاسمینوژن-1 پروتئین‌هایی هستند که می‌توانند به کاهش عوارض بیماری دیابت نوع 2 کمک نمایند. هدف از پژوهش حاضر، بررسی تأثیر هشت هفته تمرینات پیلاتس و هوازی بر سطوح سرمی سیرتوئین-1 و مهارکننده فعال کننده پلاسمینوژن-1 و شاخص مقاومت به انسولین در زنان مبتلا به دیابت نوع دوم بود. روش شناسی: در این پژوهش نیمه‌تجربی، تعداد 33 نفر از زنان مبتلا به دیابت نوع دوم (میانگین سن: 37/2±91/60 سال و میانگین BMI: 46/3±89/29 کیلوگرم بر متر مربع) بر اساس نمونه‌گیری در دسترس و هدفمند انتخاب شدند و  به صورت تصادفی ساده، در سه گروه 11 نفری هوازی، پیلاتس و کنترل قرار گرفتند. گروه پیلاتس، حرکات رشته پیلاتس را با شدت 45 تا 65 درصد ضربان قلب ذخیره و گروه هوازی، تمرینات دویدن و حرکات نرمشی را با همان شدت، به مدت هشت هفته و سه جلسه در هفته (در مجموع 24 جلسه) انجام دادند. تجزیه و تحلیل داده‌ها با استفاده از آنالیز واریانس یکطرفه و آزمون تعقیبی توکی انجام شد. یافته­ها: نتایج پژوهش حاضر نشان دهنده تفاوت معنا‌دار گروه‌های تمرین با گروه کنترل در متغیرهای وابسته پژوهش بود  به طوری که سطوح سیرتوئین-1 (001/0=p) در گروه‌های تمرین افزایش معنا‌دار و مهارکننده فعال کننده پلاسمینوژن-1 (001/0=p)  و مقاومت به انسولین (001/0=p) در این گروه‌ها کاهش معنا‌داری داشت. نتیجه گیری: تمرینات هوازی و پیلاتس با تاثیر معنا‌دار عوامل موثر در بهبود شرایط بیماری دیابت، می تواند تأثیر بسزایی در کمک به مبتلایان به این بیماری داشته باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of Pilates and aerobic training on serum levels of sirtoin-1, plasminogen activator inhibitor-1 and insulin resistance index in women with type 2 diabetes

نویسندگان [English]

  • Sadegh Cheragh-Birjandi 1
  • ali kheyrandish 2
  • seyedeh sepide tara 3
  • seyedeh sahar sharifian 4
  • halimeh masoodi 4
  • sara Asghari 5
1 Department of Physical Education, Isalmic Azad University, Bojnourd branch, Bojnourd, Iran
2 birjand university
3 bojnord
4 bojnord
5 PhD Candidate in Sports Physiology - Islamic Azad University, Bojnord Branch
چکیده [English]

Aim:      Diabetes causes a wide range of serious health problems in humans. Sirtoin-1 and plasminogen activator inhibitor-1 are proteins that can help reduce the complications of type 2 diabetes. The purpose of this study was to investigate the effect of eight weeks of pilates and aerobic exercises on serum levels of sirtuin-1 and plasminogen activator inhibitor-1 and insulin resistance index in women with type 2 diabetes. Methods:  In this semi-experimental research, 33 women with type 2 diabetes (mean age: 60.91±2.37 and mean BMI: 29.89±3.46) were selected based on available and targeted sampling and were Randomly, they were placed in three groups of 11 people: Aerobics, Pilates and Control. The Pilates group performed Pilates exercises with an intensity of 45-65% of the reserve heart rate, and the aerobic group performed running exercises and relaxation exercises with the same intensity for eight weeks and three sessions per week (24 sessions in total). Data analysis was performed using one-way analysis of variance and Tukey's post hoc test. Results:  The results of the present study showed a significant difference between the training groups and the control group in the dependent variables of the research, so that the levels of sirtuin-1 (p=0.001) in the training groups increased significantly and plasminogen activator inhibitor-1 (p=0.001) And insulin resistance (p=0.001) was significantly reduced in these groups. Conclusion:  Aerobic exercises and pilates can have a significant effect in helping those suffering from this disease with the significant effect of effective factors in improving the condition of diabetes.

کلیدواژه‌ها [English]

  • Pilates training
  • aerobic training
  • sirtoin-1
  • plasminogen activator inhibitor-1
  • insulin resistance

مراجع

  1. 1. Delpisheh M, Firouzkouhi M, Rahnama M, Badakhsh M, Abdollahimohammad A. Prevalence of gestational diabetes Mellitus in Iran: a systematic review and Meta-analysis study. 2022. [In Persian]
  2. 2. Kazemi SS, Heidarianpour A, Naddaf H, Mehri F, Naderifar H. Effect of Combined Exercise Training and Curcumin Supplementation on Metabolic Indices and Serum Levels of Sirtuin 1 in Men with Metabolic Syndrome. Avicenna Journal of Clinical Medicine. 2023;30(1):21-9. [In Persian]
  3. 3. Amiri R, Makipour F, Bostani M. The effect of eight weeks of interval training on plasma levels of sirtuin 1 and sirtuin 3 proteins in inactive elderly men. 2022. [In Persian]
  4. 4. Ranaei M, Yaghoubi A, Cheragh-Birjandi S. Effect of High-Intensity Interval Training and Portulaca Oleracea extract on Sirtuin1 Level and Insulin Resistance in Rats with Non-Alcoholic Fatty Liver Disease. Journal of Applied Health Studies in Sport Physiology. 2022;9(2):188-200. [In Persian]
  5. 5. Habibi Maleki A, Tofighi A, Ghaderi Pakdel F, Tolouei Azar J. The effect of 12 weeks of high intensity interval training and high intensity continuous training on vegf, pedf and pai-1 levels of visceral and subcutaneous adipose tissues in rats fed with high fat diet. Sport Physiology & Management Investigations. 2020;12(1):101-20. [In Persian]
  6. 6. Zhang S, Wu P, Liu J, Du Y, Yang Z. Roflumilast attenuates doxorubicin-induced cardiotoxicity by targeting inflammation and cellular senescence in cardiomyocytes mediated by SIRT1. Drug Design, Development and Therapy. 2021:87-97.
  7. 7. Kordi MR, Dokhtabdiyan R, Ahmadi A, Soori R, Akvan A. Comparison of the Effects of Two Different Protocols of High-Intensity Interval Training (HIIT) on Some Coagulation and Fibrinolytic Factors in Overweight Young Women. 2023. [In Persian]

 

  1. 8. Habibvand S, Nouri R, Gaeini A. The effect of 8 weeks of vitamin D supplementation and aerobic exercise on sirtuin-1 protein levels and oxidative stress markers of myocardial tissue in middle-aged male rats. Journal of Sport and Exercise Physiology. 2023;16(1):12-22. [In Persian]
  2. 9. Nosrati Hashi A, Bolboli L. THE EFFECT OF WALKING EXERCISE ON INSULIN RESISTANCE, LIPID PROFILE AND HEART RATE VARIABILITY IN THE ELDERLY WITH TYPE 2 DIABETES. Studies in Medical Sciences. 2023;34(7):383-96. [In Persian]
  3. 10. Aghaei N, Sherafati Moghadam M, Daryanoosh F, Shadmehri S, Jahani Golbar S. THE EFFECT OF 4 WEEKS’AEROBIC TRAINING ON THE CONTENT OF MTORC1 SIGNALING PATHWAY PROTEINS IN HEART TISSUE OF TYPE 1 DIABETES RATS. Iranian Journal of Diabetes and Metabolism. 2019;18(3):116-25. [In Persian]
  4. 11. Taghadosi M, Mirbagher Ajorpaz N, Torabian M, Sedaghati P. Investigating the effect of Pilates exercises on anxiety in women with diabetes type II. Complementary Medicine Journal of faculty of Nursing & Midwifery. 2014;4(1):687-99.
  5. 12. Supriya R, Yu AP, Lee PH, Lai CW, Cheng KK, Yau SY, et al. Yoga training modulates adipokines in adults with high‐normal blood pressure and metabolic syndrome. Scandinavian journal of medicine & science in sports. 2018;28(3):1130-8.
  6. 13. Ma JK, Scribbans TD, Edgett BA, Boyd JC, Simpson CA, Little JP, et al. Extremely low-volume, high-intensity interval training improves exercise capacity and increases mitochondrial protein content in human skeletal muscle. Open Journal of Molecular and Integrative Physiology. 2013;2013.
  7. 14. Dehbashi M, Fathi M, Attarzadeh Hosseini SR, Mosaferi Ziaaldini M. The Effect of Eight Weeks Endurance Training, Somatropin Injection, and Its Lipolytic Fragment (AOD9604) on Cytokeratin-18 and Liver Enzymes of Mice Induced Liver Damage Due to a High-Fat Diet. Internal Medicine Today. 2021;27(4):502-17. [In Persian]
  8. 15. Kamali K, Abbasi Daloii A, Abdi A, Ziaolhagh SJ, Barari A. Effect of 8-weeks aerobic training on undercarboxylated osteocalcin, hs-CRP and inisulin resistance in ovreweight women. Journal of Sabzevar University of Medical Sciences. 2015;22(5):823-31.
  9. 16. Altalhi R, Pechlivani N, Ajjan RA. PAI-1 in diabetes: pathophysiology and role as a therapeutic target. International journal of molecular sciences. 2021;22(6):3170.
  10. 17. Siahkouhian M, Ebrahimi-Torkmani B. Effect of 8-week Aerobic Exercise on Anthropometric Indices, Atherogenic Index of Plasma and Some Cardiovascular Risk Factors in Inactive Men. The Scientific Journal of Rehabilitation Medicine. 2021;10(3):446-57. [In Persian]
  11. 18. Shadmehri S, Aghaei F, Mirfallah Lialestani SN. The effect of silymarin and pilates training on anthropometric indices, blood sugar and some liver enzymes in diabetic women with obesity. Sport Physiology & Management Investigations. 2022;14(1):113-25. [In Persian]
  12. 19. Kharghani A, Rezaeian N. Effect of Aerobic Training on Serum Levels of Sirtuin1 and Insulin Resistance in Obese Men with Type 2 Diabetes. Journal of Applied Exercise Physiology. 2022;18(35):153-64. [In Persian]
  13. 20. Dalir T, Gharakhanlou R, Peeri M, MATIN HH. The Effect of Four Weeks of Aerobic Training on the Expression of Sirt1, CREB and BDNF Genes in Hippocampus of Male Wistar Rats with Alzheimer’, s Disease. 2020. [In Persian]
  14. 21. Smith DL, Fernhall B. Advanced cardiovascular exercise physiology: Human Kinetics; 2023.
  15. 22. REZAEIMANESH D, Amiri FP. The effect of eight weeks of aquatic exercise on fibrinolytic (t-PA, PAI-1, t-PA/PAI-1 complex and D-dimer) indexes in retired athletes. 2022. [In Persian]
  16. 23. Sackett JR, Farrell DP, Nagelkirk PR. Hemostatic adaptations to high intensity interval training in healthy adult men. International Journal of Sports Medicine. 2020;41(12):867-72.
  17. 24. Khademi A, Tofighi A, Tolouei Azar J, Saify Nabiabad H, Nouri Habashi A. The Effect of Aerobic and Resistance Training on Some Coagulation (PAI-1, Fibrinogen, PT, PTT) and Fibrinolysis (t-PA, Plasminogen and D-Dimer) Factors in Sedentary Obese Women. Journal of Sport Biosciences. 2021;13(1):39-57. [In Persian]
  18. 25. Khalilinejad M, Gholami M, Shah Mohammadi Dermani F, Ghazalian F. The Effect of Swimming Training on the Insulin Resistance and Expression of Adiponectin and APPL-1 Liver Genes Following Induced Polycystic Ovary Syndrome in Rats. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2023;26(1):40-53. [In Persian]
  19. 26. Stepto N, Hiam D, Gibson-Helm M, Cassar S, Harrison C, Hutchison S, et al. Exercise and insulin resistance in PCOS: muscle insulin signalling and fibrosis. Endocrine connections. 2020;9(4):346.
مطالعات کاربردی تندرستی در فیزیولوژی ورزش

مقالات آماده انتشار، پذیرفته شده
انتشار آنلاین از تاریخ 05 اسفند 1402

فایل ها

سابقه مقاله

  • تاریخ دریافت: 19 آذر 1402
  • تاریخ بازنگری: 04 اسفند 1402
  • تاریخ پذیرش: 05 اسفند 1402

هم رسانی

ارجاع به این مقاله

آمار