اثر تمرین هوازی روی تردمیل بر سطوح آدیپولین، گلوکز و انسولین در رت‌‌های نر دیابتی نوع 2

نوع مقاله: مقاله پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی دانشگاه گیلان، رشت، ایران

2 استادیار گروه فیزیولوژی ورزش، دانشکده تربیت بدنی و علوم ورزشی دانشگاه گیلان، رشت، ایران.

چکیده

Secretion of pro-inflammatory and anti-inflammatory cytokines play a critical role in the regulation of metabolic conditions. This study examines the effect of eight weeks aerobic training on Adipolin cytokine and insulin resistance index in type 2 diabetic male rats.
Eighteen 8-10 weeks Wister rats with 200-220 gr are selected and they divided equaly into two diabetes [DBT] and control [CON] groups randomly. The training program includes 8 weeks of endurance training on a treadmill at a constant dip of 5%. The speed started from 10 meters per minute and it rised to the 25 meters per minute and its time started from 15 minutes to 45 minutes. In end of 8 weeks training, blood samples were taken after 12 hours of fasting in order to determination of insulin, glucose and Adipulin levels. The homeostatic model assessment [HOMA] was calculated as insulin resistance index. The data were analyzed using the an independent t test with the SPSS software ver. 16.
A meaningful increase was observed in adipolin (1.36±0.054 vs. 1.11±0.065 ng/ml; p=0.002), and decrease in glucose (276.88±27.59 vs. 324.55±16.04 mg/dl; p=0.001), insulin (0.206±0.02 vs. 0.235±0.02 mU/l; p=0.033) and insulin resistance (2.55±0.495 vs. 3.40±0.468 mg/dl; p=0.002).
According to the findings, it seems that aerobic training with moderate intensity will lead to decreasing in insulin resistance and increase in serum levels of Adipulin in type 2 diabetic rats.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The effect of treadmill aerobic training on adipolin, glucose and insulin in type 2 diabetic male rats

نویسندگان [English]

  • Rahim Rahim Pour 1
  • Javad Mehrabani 2
1 MSc in Exercise Physiology, University of Guilan, Rasht, Iran
2 Assistant Professor in Exercise Physiology, University of Guilan, Rasht, Iran.
چکیده [English]

Background and objective: Secretion of pro-inflammatory and anti-inflammatory cytokines play a critical role in the regulation of metabolic conditions. This study examines the effect of eight weeks aerobic training on Adipolin cytokine and insulin resistance index in type 2 diabetic male rats.
Materials and procedures: Eighteen 8-10 weeks Wister rats with 200-220 gr are selected and they divided equaly into two diabetes [DBT] and control [CON] groups randomly. The training program includes 8 weeks of endurance training on a treadmill at a constant dip of 5%. The speed started from 10 meters per minute and it rised to the 25 meters per minute and its time started from 15 minutes to 45 minutes. In end of 8 weeks training, blood samples were taken after 12 hours of fasting in order to determination of insulin, glucose and Adipulin levels. The homeostatic model assessment [HOMA] was calculated as insulin resistance index. The data were analyzed using the an independent t test.
Findings: Comparisons of two groups showed that a meaningful increase in Adipulin and decrease in glucose and insulin resistance.
Conclusion: According to the findings, it seems that aerobic training with moderate intensity will lead to decreasing in insulin resistance and increase in serum levels of Adipulin in type 2 diabetic rats.

کلیدواژه‌ها [English]

  • aerobic training
  • Adipolin
  • Insulin resistance
  • Type 2 diabetes