تاثیر تمرین ترکیبی و بی‌تمرینی متعاقب آن بر سطوح آپلین در زنان دیابتی نوع دو

نوع مقاله : مقاله پژوهشی Released under CC BY 4.0 license I Open Access I

نویسندگان

گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه صنعتی شاهرود، شاهرود، ایران

10.22049/jahssp.2022.27848.1476

چکیده

هدف: پژوهش حاضر با هدف بررسی تاثیر دوازده هفته تمرین ترکیبی و هشت هفته بی‌تمرینی متعاقب آن بر سطوح اپلین در زنان دیابتی نوع دو انجام‌شد. روش شناسی: در این مطالعه تجربی،30 زن دیابتی یائسه با دامنه سنی 50 تا 65 سال، دارای اضافه وزن (شاخص توده بدن: 835/0 ± 42/30 Kg/m2) به دو گروه تمرین (15 نفر) و کنترل (15 نفر) تقسیم شدند. گروه تمرین در یک برنامه تمرینی ترکیبی هوازی (50 تا 75 درصد حداکثر ضربان قلب ذخیره) و مقاومتی (50 تا 75 درصد یک تکرار بیشینه) به مدت دوازده هفته به تمرین پرداختند و پس از آن هشت  هفته بی‌تمرینی را تجربه کردند. خونگیری قبل از شروع تمرینات، 48 ساعت بعد از آخرین جلسه تمرین و بعد از دوره بی‌تمرینی انجام و مقادیر آپلین، انسولین سرم خون، قند خون ناشتا و درصد چربی بدن اندازه‌گیری شد. داده‌ها با استفاده از آنالیز واریانس با اندازه‌گیری مکرر تحلیل شدند. یافته‌ها: سطح سرمی آپلین در گروه تمرین در پایان دوره تمرین افزایش معنادار یافته بود (04/0=p) و در دوره بی­تمرینی نیز کاهش معنادار یافته بود (001/0=p)، همچنین این تغییرات به نسبت گروه کنترل نیز معنادار بود (016/0=p). سطح قند خون و انسولین ناشتا نیز در گروه تمرین نسبت به کنترل کاهش معناداری در پایان دوره تمرین و بی‌تمرینی داشت (001/0=p). نتیجه‌گیری: به نظر می‌رسد تمرین ترکیبی موجب افزایش آپلین می‌شود و بی‌تمرینی نیز می‌تواند تا حدودی اثرات مثبت تمرین را در این مورد تخریب کند.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of combined training and subsequent detraining on plasma apelin levels in women with type 2 diabetes

نویسندگان [English]

  • Adel Donyaei
  • Fatemeh Shabani
  • farhad gholami
Department of Sports Physiology, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Iran
چکیده [English]

Aim: The present study aimed to investigate the effect of twelve weeks of combined training and subsequent eight weeks of detraining on apelin levels in type 2 diabetic women.  Methods: In this experimental study, 30 postmenopausal diabetic women with an age range of 50 to 65 years, overweight (body mass index: 30.42 ± 0.835 Kg / m2) were divided into experimental (n=15) and control (n=15) groups. The experimental group trained for a 12 weeks. Training program (3 sessions per week) according to the combined aerobic program ( 50 to 75  percent of the maximum reserve heart rate) and then resistance training ( 50 to 75 percent of one maximum repetition) and then experienced three weeks of detraining. The apelin level, insulin, fasting blood sugar, insulin resistance, and percent body fat were measured. Data were analyzed by repeated measure ANOVA at a significance level of (p>0.05). Results: Serum Aplin level in the training group increased significantly at the end of the training period (p = 0.04) and decreased significantly in the detraining period (p = 0.001). Also, these changes compared to the control group was significant (p = 0.016). Fasting blood sugar and insulin levels in the training group compared to the control had a significant decrease at the end of the training and detraining period (p = 0.001). Conclusion: Combined exercise seems to increase aplin and detraining can partially destroy the positive effects of exercise in this regard.

کلیدواژه‌ها [English]

  • Apelin
  • Detraining
  • combined training.diabetes
  1. 1. Castan-Laurell I, Dray C, Valet P. The therapeutic potentials of apelin in obesity-associated diseases. Molecular and Cellular Endocrinology. 2021:111278.
  2. 2. Xu H, Wang Q, Wang Q, Che XQ, Liu X, Zhao S, et al. Clinical significance of apelin in the treatment of type 2 diabetic peripheral neuropathy. Medicine. 2021;100(17).
  3. 3. Cheng X, Cheng XS, Pang CC. Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats. European journal of pharmacology. 2003;470(3):171-5.
  4. 4. Boucher J, Masri B, Daviaud D, Gesta S, Guigné C, Mazzucotelli A, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology. 2005;146(4):1764-71.
  5. 5. Daviaud D, Boucher J, Gesta S, Dray C, Guigne C, Quilliot D, et al. TNFα up regulates apelin expression in human and mouse adipose tissue. The FASEB Journal. 2006;20(9):1528-30.
  6. 6. Soriguer F, Garrido-Sanchez L, Garcia-Serrano S, Garcia-Almeida JM, Garcia-Arnes J, Tinahones FJ, et al. Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus. Obesity surgery. 2009 Nov;19(11):1574-80.
  7. 7. Xu N, Wang H, Fan L, Chen Q. Supraspinal administration of apelin-13 induces antinociception via the opioid receptor in mice. Peptides. 2009 Jun;30(6):1153-7.
  8. 8. Jafari M, Yekrangi Z, Marhamati M, Reyhani M, Karimi H. Acute Effects of Aerobic and Anaerobic Activities on blood Adipokines and Vascular Adhesive Molecules in Young Women. Journal of Applied Health Studies in Sport Physiology. 2020;7(1):65-72. [In Persian]
  9. 9. Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res. 2002 Sep 6;91(5):434-40.
  10. 10. Heinonen MV, Purhonen AK, Miettinen P, Pääkkönen M, Pirinen E, Alhava E, et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regulatory peptides. 2005 Aug 15;130(1-2):7-13.
  11. 11. Bertrand C, Valet P, Castan-Laurell I. Apelin and energy metabolism. Frontiers in physiology. 2015;6:115.
  12. 12. Rajabi H, donyai a, Motamedi P, Dehkhoda MR. Effect of Aerobic Training on Blood Pressure, HbA1c and Arterial Stiffness in Postmenopausal Women with Type 2 Jundishapur Scientific Medical Journal. 2018;16(6):631-42. [In Persian]
  13. 13. Zouhal H, Zare-Kookandeh N, Haghighi MM, Daraei A, de Sousa M, Soltani M, et al. Physical activity and adipokine levels in individuals with type 2 diabetes: A literature review and practical applications. Reviews in Endocrine and Metabolic Disorders. 2021:1-25.
  14. 14. Warburton DER, Bredin SSD. Health benefits of physical activity: a systematic review of current systematic reviews. Current opinion in cardiology. 2017 Sep;32(5):541-56.
  15. 15. Humphreys BR, McLeod L, Ruseski JE. Physical activity and health outcomes: evidence from Canada. Health economics. 2014 Jan;23(1):33-54.
  16. 16. Rahim Pour R, Mehrabani J. The effect of treadmill aerobic training on adipolin, glucose and insulin in type 2 diabetic male rats. Journal of Applied Health Studies in Sport Physiology. 2018;5(1):93-105. [In Persian]
  17. 17. Zhang J, Ren CX, Qi YF, Lou LX, Chen L, Zhang LK, et al. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sci. 2006 Aug 15;79(12):1153-9.
  18. 18. Li L, Yang G, Li Q, Tang Y, Yang M, Yang H, et al. Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2006 Nov;114(10):544-8.
  19. 19. Castan-Laurell I, Vítkova M, Daviaud D, Dray C, Kováciková M, Kovacova Z, et al. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. European journal of endocrinology. 2008 Jun;158(6):905-10.
  20. 20. El Wakeel MA, El-Kassas GM, Kamhawy AH, Galal EM, Nassar MS, Hammad EM, et al. Serum apelin and obesity-related complications in Egyptian children. Open access Macedonian journal of medical sciences. 2018;6(8):1354.
  21. 21. Jang S-H, Paik I-Y, Ryu J-H, Lee T-H, Kim D-E. Effects of aerobic and resistance exercises on circulating apelin-12 and apelin-36 concentrations in obese middle-aged women: a randomized controlled trial. BMC women's health. 2019;19(1):1-8.
  22. 22. Jorge ML, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz AL, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011 Sep;60(9):1244-52.
  23. 23. Kemi OJ, Haram PM, Wisløff U, Ellingsen Ø. Aerobic fitness is associated with cardiomyocyte contractile capacity and endothelial function in exercise training and detraining. Circulation. 2004 Jun 15;109(23):2897-904.
  24. 24. Puffer JC. The athletic heart syndrome: ruling out cardiac pathologies. Phys Sportsmed. 2002 Jul;30(7):41-7.
  25. 25. Zarei M, Beheshti Nasr SMB, Hamedinia M, Taheri Chadorneshin H, Askari Majdabadi H. Effects of 12 weeks of combined aerobic-resistance exercise training on levels of chemerin, omentin and insulin resistance in men with type 2 Koomesh journal. [Research]. 2020;22(1):155-63. [In Persian].
  26. 26. Delavar R, Heidarianpour A. The effect of aerobic exercise training on plasma apelin levels and pain threshold in T1DM rats. Iranian Red Crescent medical journal. 2016;18(9). [In Persian].
  27. 27. Kadoglou NP, Vrabas IS, Kapelouzou A, Lampropoulos S, Sailer N, Kostakis A, et al. The impact of aerobic exercise training on novel adipokines, apelin and ghrelin, in patients with type 2 Medical science monitor: international medical journal of experimental and clinical research. 2012;18(5):CR290.
  28. 28. Nasiri S, Banitalebi E, Faramarzi M. Effects of two exercise modalities of sprint interval training and combined training (strength-aerobic) on serum apelin levels and insulin resistance in women with type 2 Iranian Journal of Nursing Research. 2018;13(1):40-6. [In Persian].
  29. 29. Bertrand C, Valet P, Castan-Laurell I. Apelin and energy metabolism. Frontiers in physiology. 2015;6:115.
  30. 30. Soriguer F, Garrido-Sanchez L, Garcia-Serrano S, Garcia-Almeida JM, Garcia-Arnes J, Tinahones FJ, et al. Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus. Obesity surgery. 2009;19(11):1574-80.
  31. 31. Frier BC, Williams DB, Wright DC. The effects of apelin treatment on skeletal muscle mitochondrial content. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2009;297(6):R1761-R8.
  32. 32. Alavizadeh N, Mabhot Moghadam T. Effect of aerobic exercise with 75-85% of maximum heart rate on apelin and insulin resistance index in sedentary men. The Horizon of Medical Sciences. 2017;23(1):55-61. [In Persian].
  33. 33. Ryan AS, Ortmeyer HK, Sorkin JD. Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose tolerance. American Journal of Physiology-Endocrinology and Metabolism. 2012;302(1):E145-E52.
  34. 34. Dagamajalu S, Rex D, Philem PD, Rainey JK, Prasad TK. A network map of apelin-mediated signaling. Journal of Cell Communication and Signaling. 2021:1-7.
  35. 35. Choi K, Kim Y-B. Molecular mechanism of insulin resistance in obesity and type 2 The Korean journal of internal medicine. 2010;25(2):119.
  36. 36. Wu H, Ballantyne CM. Metabolic inflammation and insulin resistance in obesity. Circulation research. 2020;126(11):1549-64.
  37. 37. Ebrahimzadeh M, Azizbeigi K, Mohammad Zadeh Salamat K, Pashaie S. The Effect of Aerobic Exercise Training and Curcumin on Aplin Levels, Insulin Resistance and Glucose in Rats with Type 2 Diabetes. Researches in Sport Sciences and Medical Plants. 2021;1(3):1-12. [In Persian].
  38. 38. Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes care. 2010;33(12):e147-e67.

 

دوره 9، شماره 2
این شماره در دست تکمیل می باشد.
شهریور 1401
  • تاریخ دریافت: 06 خرداد 1401
  • تاریخ بازنگری: 13 مرداد 1401
  • تاریخ پذیرش: 14 شهریور 1401
  • تاریخ اولین انتشار: 14 شهریور 1401