تاثیر تمرین ورزشی هوازی و مقاومتی بر مقادیر GDF11 بافت قلب رت‌های سالمند

نوع مقاله : مقاله پژوهشی Released under CC BY 4.0 license I Open Access I

نویسندگان

1 کارشناسی ارشد فیزیولوژی ورزشی، گروه علوم ورزشی، دانشگاه شاهد، تهران، ایران

2 استادیار، گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه شاهد تهران، ایران

10.22049/jahssp.2022.27747.1452

چکیده

هدف: سالمندی با افزایش اختلالات عملکردی و مورفولوژیک در بافت قلب و متعاقبا افزایش خطر بروز بیماری­های قلبی عروقی همراه است. فاکتور تمایز رشد 11 (GDF11) اخیرا به عنوان عامل ضد پیری در بافت قلب معرفی شده است. بنابراین، هدف مطالعه حاضر بررسی تاثیر تمرین ورزشی هوازی و مقاومتی بر مقادیر این عامل در بافت قلب رت­های سالمند بود. روش شناسی: بدین منظور از 24 سر رت نر سالمند در 3 گروه کنترل، تمرین مقاومتی (بالا رفتن از نردبان با مقاومت 55 تا 85 درصد یک تکرار بیشینه، 3 جلسه در هفته) و تمرین هوازی (شنا با مقاومتی معادل 3-6 درصد وزن بدن، چهار جلسه در هفته، جلسه­ای 45 دقیقه) استفاده شد. پس از هشت هفته وزن قلب و مقادیر GDF11 بافت قلب اندازه­گیری شد. یافته‌ها: نتایج آزمون تحلیل واریانس یک طرفه داده­ها نشان داد تمرین مقاومتی و هوازی به ترتیب باعث افزایش 1/5 و 6/4 درصدی GDF11 بافت قلب شد، با این وجود این تغییرات به لحاظ آماری معنادار نبود (59/0=P). همچنین، وزن عضله قلب نسبت به وزن بدن در هر دو گروه تمرین مقاومتی و هوازی به ترتیب 9/5 و 3 درصد در مقایسه با گروه کنترل کمتر بود (67/0=P). نتیجه‌گیری: روند تغییرات مقادیر GDF11 و نسبت وزن قلب به وزن بدن مشاهده شده در مطالعه حاضر تایید کننده نقش پیشنهاد شده برای این پروتئین در کنترل هایپرتروفی پاتولوژیکی ناشی از سالمندی است. با وجود این به نظر می­رسد تمرین ورزشی، دست کم با شدت، مدت و نوع تمرین ورزشی استفاده شده در مطالعه حاضر، تاثیر معناداری بر مقادیر این پروتئین ندارد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Aerobic and Resistance Training on Levels of GDF11 in Cardiac Tissue of Elderly Rats

نویسندگان [English]

  • Fatemeh Mashhadi 1
  • Esmail Nasiri 2
  • Maryam Khalesi 2
1 Master of Sports Physiology, Department of Sports Science, Shahed University, Tehran, Iran
2 Assistant Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahed University, Tehran, Iran.
چکیده [English]

Aim: Aging is associated with increased functional and morphological alteration in cardiac tissue which in turn increases the risk of cardiovascular diseases. Recently Growth Differentiation Factor 11 (GDF11) is suggested as anti-aging factor in cardiac tissue, so the present study aimed at investigating the effect of aerobic and resistance training on cardiac tissue levels of GDF11 in elderly rats. Methods:  Twenty four elderly male rats were used and divided into 3 groups: control, resistance training (Climbing the ladder with a resistance of 55 to 85% of a maximum repetition, 3 sessions per week) and aerobic training (swimming with a load equal to 3-6% of body weight, 4 sessions per week, 45 minutes per session). After eight weeks, heart weight and GDF11 levels of cardiac tissue were assessed. Results:   The results of one-way analysis of variance test showed that resistance and aerobic training increased GDF11 of cardiac tissue by 5.1% and 4.6%, respectively; however, the changes were not statistically significant (p= 0.59). Also, comparing to the control group the heart to body weight ratio was 5.9% and 3% lower in both resistance and aerobic training groups, respectively (p= 0.67). Conclusions: The trend of changes in GDF11 levels and heart to body weight ratio observed in the present study supports the proposed role for GDF11 in the control of aging related pathological hypertrophy. However, it seems that training, at least with the intensity, duration and type used in the present study, does not have a significant effect on the levels of this protein. 
 

کلیدواژه‌ها [English]

  • Pathological hypertrophy
  • GDF11
  • resistance training
  • aerobic training
  • Aging
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دوره 9، شماره 1
فروردین 1401
صفحه 114-124
  • تاریخ دریافت: 16 فروردین 1401
  • تاریخ بازنگری: 23 اردیبهشت 1401
  • تاریخ پذیرش: 26 اردیبهشت 1401
  • تاریخ اولین انتشار: 26 اردیبهشت 1401