بررسی اثر دوازده هفته تمرین در آب بر تغییرات fetuin-A ، ANGPTL4 و FGF21 در زنان چاق مبتلا به دیابت نوع دو

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دکتری فیزیولوژی ورزشی دانشگاه ارومیه، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

2 استادیار فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه مراغه، مراغه، ایران.

10.22049/jahssp.2021.27436.1390

چکیده

هدف: در حال حاضر، هپاتوکین­هایی نظیر fetuin-A، ANGPTL4 و FGF21 اهداف بالقوه برای درمان اختلالات ناشی از دیابت نوع دو به ­شمار می­روند.  پژوهش حاضر با هدف بررسی تاثیر 12 هفته تمرین در آب بر هپاتوکین­های سرمی fetuin-A ، ANGPTL4 و FGF21 در زنان چاق مبتلا به دیابت نوع دو انجام شد. روش شناسی: بدین منظور، 44 زن مبتلا به دیابت با میانگین سن 19/6±16/55 و شاخص توده بدنی 32/1±52/31 کیلوگرم بر متر مربع، بطور تصادفی در دو گروه کنترل (22 نفر) و تمرین در آب (22 نفر) قرار گرفتند. گروه تمرینی سه جلسه در هفته به مدت 12 هفته تمرینات داخل آب را با شدت 60-75 درصد ضربان قلب بیشینه اجرا کردند. گروه کنترل روند طبیعی فعالیت­های روزمره را دنبال کردند. نمونه­های خون قبل و بعد از تمرین جمع آوری شد. مقادیر سرمی گلوکز ناشتا، انسولین، شاخص مقاومت به انسولین، HbA1C، fetuin-A، ANGPTL4 ، FGF21 و پروفایل لیپیدی اندازه گیری شد. داده­ها با استفاده از آزمون کوواریانس تجزیه و تحلیل شدند. یافته­ها: سطوح سرمی گلوکز، انسولین، مقاومت انسولینی، HbA1C، fetuin-A ، ANGPTL4 و درصد چربی در گروه تجربی پس از 12 هفته تمرین در آب نسبت به گروه کنترل به­طور معنی­داری کاهش یافت (05/0>p). همچنین، تمرین در آب باعث افزایش معنی­دار سطوح FGF21 در گروه تجربی نسبت به گروه کنترل شد (p <0.05). تمرین در آب باعث کاهش معنی­دار شاخص­های TC ، TG و LDL در گروه تجربی شد (05/0>p)؛ اما افزایش HDL معنی­دار نبود (21/0=p). نتیجه گیری: به نظر می­رسد تمرینات داخل آب به­عنوان روش درمانی مکمل می­تواند در بهبود عارضه بیماران مبتلا به دیابت نوع دو مفید باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of 12 weeks of aquatic training on changes in fetuin-A, ANGPTL4 and FGF21 in obese women with type 2 diabetes

نویسندگان [English]

  • Samaneh Dastah 1
  • Solmaz Babaei 2
1 PhD .of exercise physiology, Urmia University, Urmia, Iran.
2 Assistant Professor of Sports Physiology, Department of Sports Science, Faculty of Humanities ,University of Maragheh, Maragheh, Iran.
چکیده [English]

Aim: Hepatokines such as fetuin-A, ANGPTL4 and FGF21 are now considered potential targets for the treatment of type 2 diabetes disorders. Therefore, the aim of this study was to investigate the effect of 12 weeks of aquatic training on some serum hepatokines fetuin-A, ANGPTL4 and FGF21 in obese women with type 2 diabetes. Methods: For this purpose, 44 diabetic women (aged 55.16±6.19 years, BMI 31.52±1.32 kg / m2) were randomly divided into two groups of control (n = 22) and water exercise (n = 22). The training group performed underwater exercises for 12 weeks three sessions a week with an intensity of 75-60% of maximum heart rate. The control group followed the normal process of daily activities. Blood samples were collected before and after exercise. Fasting serum glucose, insulin, insulin resistance index, plasma hemoglobin, fetuin-A, angiopoietin-4, fibroblast growth factor-21, and lipid profile to calculate. Data were analyzed using ANCOA test. Results: Serum levels of glucose, HbA1C, fetuin-A, ANGPTL4, fat percentage, insulin and insulin resistance in the experimental group decreased significantly after 12 weeks of water training compared to the control group (p <0.05). Also, exercise in water significantly increased FGF21 levels in the experimental group compared to the control group (p <0.05). Exercise in water significantly reduced TC, TG and LDL indices in the experimental group (p <0.05); But the increase in HDL was not significant (p = 0.21).Conclusion: It seems that water exercise as a complementary therapy can be useful in improving the complication of patients with type 2 diabetes.

کلیدواژه‌ها [English]

  • aquatic exercise
  • diabetes
  • ANGPTL4
  • fetuin-A
  • FGF21
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دوره 8، شماره 2
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