اثر تمرین در آب بر مقدار Fetuin-A، ANGPTL4 و FGF21 سرم زنان چاق مبتلا به دیابت نوع دو

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 دکتری فیزیولوژی ورزشی دانشگاه ارومیه، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

2 دانشیار فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه مراغه، مراغه، ایران.

10.22049/jahssp.2021.27436.1390

چکیده

هدف: هپاتوکین­هایی نظیر fetuin-A، ANGPTL4 و FGF21 از اهداف بالقوه درمان اختلالات دیابت نوع دو به ­شمار می­روند. هدف پژوهش حاضر بررسی تاثیر 12 هفته تمرین در آب بر مقدار سرمی fetuin-A، ANGPTL4 و FGF21 در زنان چاق مبتلا به دیابت نوع دو بود. روش‌شناسی: بدین منظور، 44 زن مبتلا به دیابت با میانگین سن 19/6±16/55 و شاخص توده بدنی 32/1±52/31 کیلوگرم بر متر مربع، به طور تصادفی در دو گروه کنترل (22 نفر) و تمرین در آب (22 نفر) قرار گرفتند. گروه تمرینی سه جلسه در هفته به مدت 12 هفته تمرینات داخل آب را با شدت 60-75 درصد ضربان قلب بیشینه اجرا کردند. گروه کنترل روند طبیعی فعالیت­های روزمره را دنبال کردند. نمونه­های خون قبل و بعد از تمرین جمع آوری شد. مقادیر سرمی گلوکز ناشتا، انسولین، شاخص مقاومت به انسولین، HbA1C، Fetuin-A، ANGPTL4، FGF21 و پروفایل لیپیدی اندازه گیری شد. داده­ها با استفاده از آزمون کوواریانس تجزیه و تحلیل شدند. یافته­ها: سطوح سرمی گلوکز، انسولین، مقاومت انسولینی، HbA1C، Fetuin-A، ANGPTL4 و درصد چربی در گروه تجربی پس از 12 هفته تمرین در آب نسبت به گروه کنترل به­طور معنی­داری کاهش یافت (05/0>p). همچنین، تمرین در آب باعث افزایش معنی‌­دار سطوح FGF21 در گروه تجربی نسبت به گروه کنترل شد (p<0.05). تمرین در آب باعث کاهش معنی­‌دار شاخص­های TC ، TG و LDL در گروه تجربی شد (05/0>p)؛ اما افزایش HDL معنی­دار نبود (21/0=p). نتیجه گیری: به نظر می‌رسد تمرینات در داخل آب می ­توانند در بهبود عوارض دیابت نوع دو مفید باشند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of aquatic training on serum Fetuin-A, ANGPTL4 and FGF21 levels in type 2 diabetic obese women

نویسندگان [English]

  • Samaneh Dastah 1
  • Solmaz Babaei 2
1 PhD in Sports Physiology, Urmia University, Faculty of Sports Sciences, Urmia University, Urmia, Iran.
2 Associate Professor of Sports Physiology, Department of Sports Science, Faculty of Humanities ,University of Maragheh, Maragheh, Iran.
چکیده [English]

Aim: Some hepatokines e.g. Fetuin-A, ANGPTL4 and FGF21 are considered as potential factors for type 2 diabetes disorders treatment. The aim of this study was to investigate effects of 12 weeks of aquatic exercise on some serum fetuin-A, ANGPTL4 and FGF21 levels in obese women with type 2 diabetes. Methods: For this purpose, 44 diabetic women aged 50-60 years with a body mass index higher than 25 kg / m2 were randomly divided into two groups of control (n = 22) and water exercise (n = 22). The training group performed underwater exercises for 12 weeks three sessions a week at 75-60% of MHR. The control group followed the normal process of daily activities. Blood samples were collected before and after exercise. Fasting serum glucose, insulin, plasma hemoglobin, fetuin-A, angiopoietin-4, fibroblast growth factor-21, and lipid profile to calculate insulin resistance index. Data were analyzed using ANCOA test. Results: Serum levels of FBS, HbA1C, fetuin-A, ANGPTL4, fat percentage, insulin and insulin resistance in the experimental group decreased significantly after 12 weeks of water training compared to the control group (p<0.05). Also, exercise in water significantly increased FGF21 levels in the experimental group compared to the control group (p<0.05). Exercise in water significantly reduced TC, TG and LDL indices in the experimental group (p<0.05); But the increase in HDL was not significant (p = 0.21). Conclusion: It seems that aquatic could reduce diabetes complications.

کلیدواژه‌ها [English]

  • aquatic exercise
  • diabetes
  • ANGPTL4
  • fetuin-A
  • FGF21

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 8، شماره 2
مهر 1400
صفحه 51-60

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  • تاریخ دریافت: 10 مهر 1400
  • تاریخ بازنگری: 03 آبان 1400
  • تاریخ پذیرش: 08 آبان 1400

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