اثر یک دوره تمرینات تناوبی شدید (HIIT) بر مقادیر سرمی سلنوپروتئینP، شاخص های گلیسمی و ترکیب بدنی در زنان مبتلا به کبد چرب غیرالکلی

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 دانشیار گروه فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز-ایران.

2 کارشناسی ارشد، گروه علوم ورزشی، دانشکده علوم تربیتی و روانشناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران.

10.22049/jahssp.2021.27318.1367

چکیده

هدف: بی­تحرکی و عادت­های غذایی نادرست مهم­ترین عوامل دخیل در بروز بیماری کبد چرب غیر الکلی می­باشند. بنابراین بنا به اهمیت پیشگیری از بیماری­های متابولیکی هدف پژوهش حاضر بررسی اثر یک دوره تمرینات تناوبی شدید (HIIT) بر مقادیر سرمی سلنوپروتئینP، شاخص های گلیسمی و ترکیب بدنی در زنان بیمار مبتلا به کبد چرب غیرالکلی بود. روش شناسی: مطالعه حاضر از نوع نیمه تجربی که جامعه مورد مطالعه آن زنان مبتلا به کبد چرب غیر الکلی مراجعه کننده مراکز درمانی شهر تبریز بود که 25 نفر از آن­ها به روش نمونه گیری تصادفی در دو گروه تمرین(13 نفر) و گروه کنترل (12 نفر) تقسیم شدند. پروتکل تمرین تناوبی شدید به مدت 8 هفته و چهار جلسه در هفته و هر جلسه به مدت 60 دقیقه اجرا شد. نمونه­های خونی در شرایط پیش و پس آزمون به منظور اندازه گیری مقادیر سرمی سلنوپروتئینP  و دیگر متغیرها جمع آوری شد. تحلیل آماری داده­ها با استفاده از آزمون آماری تی همبسته و مستقل بوسیله نرم افزار spss نسخه 21 درسطح معنی­داری 05/0>p انجام شد. یافته‌ها: نتایج نشان داد بعد از هشت هفته تمرینات تناوبی شدید در گروه تمرین در مقایسه با گروه کنترل مقادیر سرمی سلنوپروتئینP، شاخص مقاومت انسولینی، درصد چربی بدن، شاخص توده بدن، نسبت دور کمر به لگن و وزن بدن کاهش معنی­داری داشته­اند. نتیجه‌گیری: به نظر می­رسد اجرای تمرینات اینتروال شدید  به عنوان یک راهکار مناسب برای بهبود سطوح سلنوپروتئینP، شاخص مقاومت انسولینی و شاخص­های ترکیب بدنی در بیماران مبتلا به کبد چرب غیرالکلی می­تواند پیشنهاد شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of high intensity interval training (HIIT) on serum levels of selenoprotein P and glycemic and body composition indices in women with nonalcoholic fatty liver disease

نویسندگان [English]

  • Bahloul Ghorbanian 1
  • Safa Egtesadi 2
1 Associate Professor of Sports Physiology, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Azerbaijan Shahid Madani University, Tabriz-Iran.
2 M.Sc, Department of Exercise Sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
چکیده [English]

Aim:   Inactivity and incorrect eating habits are the most important factors in the prevalence of non-alcoholic fatty liver disease. Therefore, due to the importance of preventing metabolic diseases, the aim of this study was to evaluate the effect of high intensity interval training (HIIT) on serum levels of selenoprotein P, glycemic and body composition indices in women with non-alcoholic fatty liver disease. Methods:  The present study was a quasi-experimental study in which women with non-alcoholic fatty liver disease, 25 of whom were randomly divided into two exercise (13) and control (12) group. The HIIT protocol was performed for 8 weeks and four sessions per week for 60 minutes each session. Blood samples were taken in pre and post-test to measure serum levels of selenoprotein P and other variables. Statistical analysis of data was performed by using paired and independent t-test by spss21 software at significant level of p <0.05. Results:   The results was showed that after eight weeks of HIIT in the training group compared to the control group, the amounts of selenoprotein , insulin resistance index, body fat percentage, BMI, WHR and body weight  decreased significantly. Conclusions:   It seems that HIITcan be suggested as a suitable strategy to improve the levels of selenoprotein P, insulin resistance and body composition indices in non-alcoholic fatty liver disease.
 

کلیدواژه‌ها [English]

  • HIIT
  • Selenoprotein P
  • Non-Alcoholic Fatty Liver

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

مراجع

  1. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease—meta‐analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73-84.
  2. Ekelund U, Steene-Johannessen J, Brown WJ, Fagerland MW, Owen N, Powell KE, et al. Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. The Lancet. 2016;388(10051):1302-10.
  3. Kerr J, Anderson C, Lippman SM. Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. The Lancet Oncology. 2017;18(8):e457-e71.
  4. Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology. 2014;59(2):713-23.
  5. Nascimbeni F, Romagnoli D, Ballestri S, Baldelli E, Lugari S, Sirotti V, et al. Do nonalcoholic fatty liver disease and fetuin-A play different roles in symptomatic coronary artery disease and peripheral arterial disease? Diseases. 2018;6(1):17.
  6. Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxidants & redox signaling. 2012;16(7):705-43.
  7. Nichol C, Herdman J, Sattar N, O’Dwyer PJ, O’Reilly DSJ, Littlejohn D, et al. Changes in the concentrations of plasma selenium and selenoproteins after minor elective surgery: further evidence for a negative acute phase response? Clinical chemistry. 1998;44(8):1764-6.
  8. Mattmiller S, Carlson BA, Sordillo L. Regulation of inflammation by selenium and selenoproteins: impact on eicosanoid biosynthesis. Journal of nutritional science. 2013;2.
  9. Rayman MP. Selenium and human health. The Lancet. 2012;379(9822):1256-68.
  10. Misu H, Takayama H, Saito Y, Mita Y, Kikuchi A, Ishii K-a, et al. Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. Nature medicine. 2017;23(4):508-16.
  11. Sargeant JA, Aithal GP, Takamura T, Misu H, Takayama H, Douglas JA, et al. The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men. Applied Physiology, Nutrition, and Metabolism. 2018;43(5):482-90.
  12. Oh S, So R, Shida T, Matsuo T, Kim B, Akiyama K, et al. High-intensity aerobic exercise improves both hepatic fat content and stiffness in sedentary obese men with nonalcoholic fatty liver disease. Scientific reports. 2017;7(1):1-12.
  13. Cuthbertson DJ, Shojaee-Moradie F, Sprung VS, Jones H, Pugh CJ, Richardson P, et al. Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease. Clinical science. 2016;130(2):93-104.
  14. Balducci S, Zanuso S, Cardelli P, Salvi L, Bazuro A, Pugliese L, et al. Effect of high-versus low-intensity supervised aerobic and resistance training on modifiable cardiovascular risk factors in type 2 diabetes; the Italian Diabetes and Exercise Study (IDES). PloS one. 2012;7(11):e49297.
  15. Paluch AE, Church TS, Blair SN. Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus. Current Cardiovascular Risk Reports. 2011;5(6):481.
  16. Bacchi E, Negri C, Targher G, Faccioli N, Lanza M, Zoppini G, et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatology. 2013;58(4):1287-95.
  17. Stewart KJ, Bonekamp S, Barone BB, Bacher AC, Potrekus K, Moxley J, et al. Exercise Training Reduces Hepatic Fat in Type 2 Diabetes: A Randomized, Controlled Trial. Journal of Cardiopulmonary Rehabilitation and Prevention. 2008;28(4):269.
  18. Francois ME, Little JP. Effectiveness and safety of high-intensity interval training in patients with type 2 diabetes. Diabetes Spectrum. 2015;28(1):39-44.
  19. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr 1978;40(3):497-504 .
  20. Burk RF, Hill KE. Selenoprotein P—expression, functions, and roles in mammals. Biochimica et Biophysica Acta (BBA)-General Subjects. 2009;1790(11):1441-7.
  21. Burk RF, Hill KE. Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr. 2005;25:215-35.
  22. Ennequin G, Sirvent P, Whitham M. Role of exercise-induced hepatokines in metabolic disorders. American Journal of Physiology-Endocrinology and Metabolism. 2019;317(1):E11-E24.
  23. Stranges S, Laclaustra M, Ji C, Cappuccio FP, Navas-Acien A, Ordovas JM, et al. Higher selenium status is associated with adverse blood lipid profile in British adults. The Journal of nutrition. 2010;140(1):81-7.
  24. Ghorbanian B, Shokrollahi F. The effects of rope training on Paraoxonase-1 enzyme, insulin resistance and lipid profiles in inactive girls. 2017.
  25. Attarzadeh Hosseini SR, Mir E, Hejazi K, Mir Sayeedi M. The effect of eight weeks combined training on some insulin resistance markers in middle-aged men. medical journal of mashhad university of medical sciences. 2015;58(3):129-36.
  26. Henriksen EJ. Invited review: Effects of acute exercise and exercise training on insulin resistance. Journal of applied physiology. 2002;93(2):788-96.
  27. Poirier P, Tremblay A, Broderick TL, Catellier C, Tancrède G, Nadeau A. Impact of moderate aerobic exercise training on insulin sensitivity in type 2 diabetic men treated with oral hypoglycemic agents: is insulin sensitivity enhanced only in nonobese subjects? Medical Science Monitor. 2002;8(2):CR59-CR65.
  28. Irandoost K, RahmaniNia F, Mohebbi H, Mirzaee B, HasanNia S. Effect of aerobic training on ghrelin and leptin plasma in normal and obese women. J Olympic. 2010;50:87-99.
  29. Green JS, Stanforth PR, Rankinen T, Leon AS, Rao D, Skinner JS, et al. The effects of exercise training on abdominal visceral fat, body composition, and indicators of the metabolic syndrome in postmenopausal women with and without estrogen replacement therapy: the HERITAGE family study. Metabolism. 2004;53(9):1192-6.
  30. Donnelly JE, Hill JO, Jacobsen DJ, Potteiger J, Sullivan DK, Johnson SL, et al. Effects of a 16-month randomized controlled exercise trial on body weight and composition in young, overweight men and women: the Midwest Exercise Trial. Archives of internal medicine. 2003;163(11):1343-50.
  31. Farrel P, Joyner M, Caiozzo V, Medicine ACoS. ACSM’s Advanced Exercise Physiology. Seg. Ed. Baltimore: Lippincott Williams & Wilkins; 2012.
مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 9، شماره 1
فروردین 1401
صفحه 12-21

فایل ها

سابقه مقاله

  • تاریخ دریافت: 02 تیر 1400
  • تاریخ بازنگری: 30 تیر 1400
  • تاریخ پذیرش: 09 مرداد 1400

هم رسانی

ارجاع به این مقاله

آمار