تاثیر تمرین تناوبی شدید و مصرف کورکومین بر سطوح تروپونین I و کراتین کیناز سرمی موشهای نر تیمار شده با ایزوپرترنول

نوع مقاله : مقاله پژوهشی Released under CC BY 4.0 license I Open Access I

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه تربیت بدنی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران.

2 استادیار ، گروه تربیت بدنی،دانشگاه آزاد اسلامی واحد تبریز، تبریز، ایران.

10.22049/jahssp.2021.27276.1358

چکیده

هدف: فعالیت بدنی منظم می‌تواند در پیشگیری و بازتوانی بیماریهای قلبی- عروقی مؤثر واقع شود. با این حال، اثر ترکیبی تمرین تناوبی شدید و مصرف مکمل کورکومین بر فاکتورهای آسیب قلبی درک نشده است؛ هدف از این تحقیق تعیین تاثیر تمرین تناوبی شدید و مصرف کورکومین بر سطوح تروپونین I و کراتین کیناز سرمی موش‌های نر تیمار شده با ایزوپرترنول بود. روش شناسی: تعداد 40 سر موش صحرائی نر با تزریق درون صفاقی ایزوپرترنول(با دوز 100 میلی‌گرم بر هر کیلوگرم وزن بدن در دو روز متوالی) دچار انفاکتوس میوکارد شدند و به طور تصادفی در چهار گروه تمرین، مکمل کورکومین، توام (تمرین و مکمل کورکومین) و کنترل قرار گرفتند. در گروه تمرین، برنامه تمرینی با تناوب 4 دقیقه دویدن و سپس 2 دقیقه ریکاوری فعال به ترتیب با شدت 90-85 و 60 – 50 درصد VO2maxبود؛ که 60 دقیقه در یک روز؛ 5 بار در هفته به مدت هشت هفته انجام شد. در گروه مکمل، کورکومین روزانه 15 میلی‌گرم به ازای هر کیلوگرم وزن بدن به صورت گاواژ خوراکی استفاده شد. سطوح CK-MBوcTnI سرمی به روش الایزا اندازه‌گیری شدند. برای تجزیه‌وتحلیل داده‎ها از آزمون آماری آنوای یک‌طرفه استفاده شد. یافته‌ها: فقط مداخلات کورکومین و توام موجب کاهش معنی‌داری در سطوح cTnI سرمی شد (04/0P= و 001/0P=) تمرین به تنهایی تاثیری نداشت (44/0P=). همچنین، فقط تاثیر کورکومین و توام (کورکومین و تمرین تناوبی شدید) موجب کاهش معنی‌دار سطوح CK-MB شدند(002/0P= و 008/0P=). با این وجود، تمرین تناوبی شدید به تنهایی تاثیری معنی‌داری بر سطوح سرمی CK-MB نداشت (27/0P=). نتیجهگیری: بنابر نتایج تحقیق تمرین تناوبی شدید احتمالا باعث افزایش نشانگرهای آسیب قلبی (تروپونین I و کراتین کیناز) می‌شود و کورکومین قادر است تاحدودی نشانگرهای آسیب قلبی را کاهش دهد، اما به دلیل محدودیت‌ها و کمبود شواهد در جمعیت سکته قلبی، هنوز به بررسی‌های بیشتری نیاز است.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of HIIT and curcumin consumption on serum troponin I and creatine kinase levels in isopretrenol-treated male mice

نویسندگان [English]

  • Amir Dadashzadeh 1
  • Roghayeh Poozesh Jadidi 2
1 MS Student of Exercise Physiology, Department of Physical Education, Tabriz branch, Islamic Azad University, Tabriz, Iran.
2 Assistant Prof., Department of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, Iran.
چکیده [English]

Aim:  Regular physical activity can be effective in preventing and rehabilitating cardiovascular disease. The aim of this study was to determine the effect of aerobic training and curcumin consumption on serum troponin I and creatine kinase levels in male rats treated with isopretrenol.  Methods: 40 male rats were randomized in four groups including: control, HIIT, curcumin, HIIT+curcumin. HIIT were conducted for 8 weeks (5 d/w, 60 min/session (with 4 min running at 85-90% of Vo2max and 2 min recovery at 50-60% of Vo2max intervals) and curcumin 15 mg/bw.day, were consumed orally for entire the study period. Results: Only curcumin and Concomitant interventions significantly reduced serum cTnI levels  (P=0.04, P=0.001) and exercise alone had no effect (P=0.44). Also, only the effect of curcumin and  Concomitant (curcumin and HIIT) caused a significant decrease in CK-MB levels (P=0.002, P=0.008). However, HIIT alone had no significant effect on serum CK-MB levels (P=0.27). Conclusion: According to research, HIIT increases the markers of heart damage (troponin I and creatine kinase) and curcumin is able to reduce the markers of heart damage to some extent, However, more researches remains to be done because of the study limitations and lack of similar evidence in myocardial infarction populations.

کلیدواژه‌ها [English]

  • Troponin
  • HIIT
  • curcumin
  • CK-MB
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دوره 8، شماره 1
فروردین 1400
صفحه 44-53
  • تاریخ دریافت: 04 خرداد 1400
  • تاریخ بازنگری: 11 خرداد 1400
  • تاریخ پذیرش: 14 خرداد 1400
  • تاریخ اولین انتشار: 14 خرداد 1400