اثرات حاد فعالیت هوازی و بی‌هوازی بر آدیپوکاین‌های خون و مولکول‌های چسبان عروقی در زنان جوان

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I


1 استادیار، گروه علوم ورزشی، واحد شیروان، دانشگاه آزاد اسلامی، شیروان، ایران

2 کارشناسی ارشد فیزیولوژی ورزشی، گروه علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران



هدف: برخی مولکول های چسبان و آدیپوکاین­ها میانجی­های فرایندهای التهابی آتروسکلروتیک هستند و غلظت خونی این مواد با خطر بیماری قلبی عروقی ارتباط دارد. هدف از انجام این تحقیق بررسی تأثیر حاد دو نوع فعالیت هوازی (آزمون کوپر) و بی­هوازی (آزمون رست) بر سطوح ICAM1، VCAM1، ای سلکتین، پی سلکتین، ال سلکتین، اپلین، امنتین و فیبرینوژن بود. روش ­شناسی: 17 زن جوان چاق و سالم به طور تصادفی به دو گروه هوازی و بی­هوازی تقسیم شدند. قبل و بعد از اجرای آزمون­های مربوطه خونگیری از آنها به عمل آمد. از روش الایزا برای سنجش متغیرهای وابسته استفاده شد. یافته­ ها: تجزیه و تحلیل یافته ها نشان داد که فقط سطوح ال سلکتین پس از آزمون کوپر و سطوح فیبرینوژن پس از هر دو آزمون کاهش معنی داری داشتند (P≤0/05). بقیه متغیرها تغییرات درون گروهی معنی داری نداشتند، همچنین تغییرات هیچکدام از متغیرها بین دو گروه تفاوت معنی داری نداشت (P>0/05). نتیجه ­گیری: به طور کلی اجرای آزمون­های رست و کوپر باعث افزایش آدیپوکاین­ها و مولکول­های چسبان آتروژنیک در زنان جوان چاق نمی­ شود که می­ تواند پاسخ مطلوبی در جهت کاهش خطر حمله قلبی در حین ورزش باشد.


عنوان مقاله [English]

Acute Effects of Aerobic and Anaerobic Activities on blood Adipokines and Vascular Adhesive Molecules in Young Women

نویسندگان [English]

  • Mohsen Jafari 1
  • Zahra Yekrangi 2
  • Mahboubeh Marhamati 2
  • Mahsa Reyhani 2
  • Hoori Karimi 2
1 Assistant Professor, Department of Sport Sciences, Shirvan Branch, Islamic Azad University, Shirvan, Iran
2 Msc of Exercise Physiology, Department of Sport Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
چکیده [English]

Aim: Some adhesion molecules and adipokines are mediators of atherosclerotic inflammatory processes and blood levels of these substances are related to cardiovascular disease risk. The aim of this study was to examine the acute effects of two types of aerobic (Cooper) and anaerobic (Rast) on levels of ICAM1, VCAM1, E-selectin, P-selectin, L-selectin, omentin, apelin and fibrinogen. Methods: 17 obese and healthy young females were randomly assigned into two groups of aerobic and anaerobic tests. Blood samples were taken before and after the tests. Elisa method was used for evaluation of dependent variables. Results: Analysis of data showed that only L-selectin levels after cooper test and fibrinogen levels after both tests decreased significantly (P≤0/05). Other variables had no significant inter group changes, also changes of all of variables between two groups were not significant (P>0/05). Conclusions: Overall, implementation of Rast and Cooper tests did not induce elevation of adipokines and atherogenic adhesion molecules in obese young females that may be a beneficial response for prevention of heart attack risk during exercise.

کلیدواژه‌ها [English]

  • RAST
  • Cooper
  • Apelin
  • Omentin
  • Selectin

    1. Jafari M. The Status of Inflammatory Factors Involved in Coronary Artery Disease in Veteran Football Players. J Arch Mil Med. 2019; 7(3): e96700.
    2. Hou J, Liu Y, Xue X, Wu Y, Li R, Xu T, et al. The expression of macrophage migration inhibitory factor and intercellular adhesion molecule-1 in rats with periodontitis and atherosclerosis. Archives of oral biology. 2019; 107:104513.
    3. Kupsa T, Horacek JM, Jebavy L. The role of adhesion molecules in acute myeloid leukemia and (hemato) oncology: a systematic review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015;159(1):1-11.
    4. Dustin ML. Integrins and Their Role in Immune Cell Adhesion. Cell. 2019;177(3):499-501.
    5. Barzegari A, Asad MR, Ranjbar H. Effect of one bout continuous versus intermittent aerobic exercise on plasma levels of intercellular adhesion molecules 1 and vascular cell adhesion molecules 1 in patients with coronary heart disease. J Shahid Sadoughi Uni Med Sci 2020; 27(11): 2052-62. [In Persian]
    6. Riyahi Malayeri SH, Kaka Abdullah Shirazi S, Behdari R, mousavi Sadati SK. Effect of 8-week Swimming training and garlic intake on serum ICAM and VCAM in male obese rats. J Shahid Sadoughi Uni Med Sci. 2019; 26(10): 867-78. [In Persian]
    7. Liu Y, Davidson BP, Yue Q, Belcik T, Xie A, Inaba Y, et al. Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging. 2013; 6:74-82.
    8. Bizheh N, Jaafari M. The effect of a single bout circuit resistance exercise on homocysteine, hs-CRP and fibrinogen in sedentary middle-aged men. Iran J Basic Med Sci. 2011; 14(6):568.
    9. Zarei F, Shadmehri S, Daryanoosh F, Sherafati Moghadam M, Mahmoodi M. The effect of eight weeks high-intensity interval training (HIIT) on the serum levels of chemerin, omentin-1 and apelin on overweight female Sprague-Dawley rats. J Shahid Sadoughi Uni Med Sci. 2018; 26(6): 473-82. [In Persian]
    10. Glowinska B, Urban M, Peczynska J, Florys B. Soluble adhesion molecules (sICAM-1, sVCAM-1) and selectins (sE selectin, sP selectin, sL selectin) levels in children and adolescents with obesity, hypertension, and diabetes. Metabolism. 2005; 54:1020–6.
    11. Shephard RJ. Adhesion molecules, catecholamines and leucocyte redistribution during and following exercise. Sports Med. 2003; 33:261–84.
    12. Mizia-Stec K, Zahorska-Markiewicz B, Mandecki T, Janowska J, Szulc A, Jastrzebska-Maj E. Serum levels of selected adhesion molecules in patients with coronary artery disease. Int J Cardiol. 2002; 83:143–50.
    13. Wang JS, Chen YW, Chow SE, Ou HC, Sheu WH. Exercise paradoxically modulates oxidized low-density lipoprotein-induced adhesion molecules expression and trans endothelial migration of monocyte in men. Thromb Haemost 2005; 94:846–52.
    14. Nielsen H, Lyberg T. Long-distance running modulates the expression of leukocytes and endothelial adhesion molecules. Scand J Immunol. 2004; 60:356–62.
    15. Akimoto T, Furudate M, Saitoh M, Sugiura K, Waku T, Akama T, et al. Increased plasma concentrations of intercellular adhesion molecule-1 after strenuous exercise associated with muscle damage. Eur J Appl Physiol 2002; 86:185–190.
    16. Hosseini Abrishami L, Hejazi S, Rashdlamir A, Khajei R. The effect of eight weeks of continuous and periodic aerobic exercise on serum C-reactive protein and adhesion molecules in men with heart failure. J Sabzevar Univ Med Sci. 2019; 26(4):495-504. [In Persian]
    17. Alizad R, Motaghian A, Moradi L. The effects of 8 weeks of high intensity interval resistance training on E-selectin and white blood cell indices. J Appl Health Stud Sport Physiol. 2019; 6(1):45-52.
    18. Bizheh N, Jaafari M. Effects of regular aerobic exercise on cardiorespiratory fitness and levels of fibrinogen, fibrin D-dimer and uric acid in healthy and inactive middle-aged men. J Shahrekord Univ Med Sci. 2012; 14(3): 20-29. [In Persian]
    19. Rashidlamir A, Rashidlamir A, Ghanbari-Niaki A, Saboosi M. Effects of Anaerobic (RAST) and Aerobic (Cooper) running training programs on plasma AgRP concentrations in female students. Iran J Health Phys Activ. 2011; 2(2):25-28.
    20. Rastegar Moghaddam Mansouri S, Khodaee K, Badri N. Comparison of short term High Intensity Interval Training (HIIT) with RAST and plyometric on some cardiovascular indices, anaerobic power, sprint and jumping performance in active female students. J Sabzevar Univ Med Sci. 2014; 21(2): 332-342. [In Persian]
    21. Chadorneshin HT, Golestani A, Jamali F, Shirvan SM, Sarir H, Eivary SH. The response of intercellular adhesion molecule-1 to exhaustive submaximal exercise and its correlation with physiological and anthropometric measures. J Med Life. 2018;11(1):36.
    22. Park J, Willoughby DS, Song JJ, Leutholtz BC, Koh Y. Exercise-induced changes in stress hormones and cell adhesion molecules in obese men. J Inflam Res. 2018; 11:69.
    23. Strömberg A, Rullman E, Jansson E, Gustafsson T. Exercise induced upregulation of endothelial adhesion molecules in human skeletal muscle and number of circulating cells with remodeling properties. J Appl Physiol. 2017; 122:1145-1154.
    24. Rahmani H, Ahmadizad S, Rohani H, Nouri Habashi A, Mohammadi Dehcheshmeh M. Acute Effects of Continuous or High Intensity Interval Exercise on Plasma Levels of E-Selectin and WBC Indices in CHD Patients. Sport Physiol. 2017; 9(35):35-48. [In Persian]
    25. Barabadi A, Ravasi A, Chobineh S, Barabadi H. The Effect of a Long Prior Aerobic Exercise and High Fat Meal on Inflammatory Markers of Vascular Adhesion Molecule and Lipid Profile in Non–Athlete Males. J Sport Biosci. 2013; 5(2):133-153. [In Persian]
    26. Petridou A, Chatzinikolaou A, Fatouros I, Mastorakos G, Mitrakou A, Chandrinou H, et al. Resistance exercise does not affect the serum concentrations of cell adhesion molecules. Brit J Sport Med. 2007; 41(2):76-9.
    27. Borges L, Dermargos A, Gray S, Barros Silva MB, Santos V, Pithon-Curi TC, et al. Neutrophil migration and adhesion molecule expression after acute high-intensity street dance exercise. J Immunol Res. 2018;2018.
    28. Farsi S, Azarbayjani MA, Hosseini S, Pirei P. Response of Serum Levels of ICAM-1 VCAM-1 and CRP to High and Moderate Endurance Trainings in Sprague Dawley Male Diabetic Rats. Armaghane danesh. 2016; 21(8):757-771. [In Persian]
    29. Saboorisarein M, Yazdanpoor F, Jahromi MK. The Influence of acute morning and evening exercise on homocysteine, fibrinogen and platelet. Int J Cardiovasc Res. 2012; 1:4.
    30. Habibian M, Bakhtiar K. Comparing the Effects of Two Acute Training Methods of Continuous and High-Intensity Interval on Fibrinogen and High Sensitivity C-Reactive Protein Responses in Sedentary Women. Par J Med Sci 2015;13(3):21-29. [In Persian]
    31. Waller JD, McNeill EH, Zhong F, Vervaecke LS, Goldfarb AH. Plasma Apelin Unchanged with Acute Exercise Insulin Sensitization. J Sport Sci Med. 2019;18(3):537.
    32. Ringström C, Nitert MD, Bennet H, Fex M, Valet P, Rehfeld JF, et al. Apelin is a novel islet peptide. Regulatory peptides. 2010; 162(1-3):44-51.
    33. Kaviyani-delshad G, Vesali-akbarpoor L, SamavatiSharif MA. Omentin-1 and chemerin’s response to two different exercise models in overweight men. J Fasa Univ Med Sci. 2019;9(1):1220-9. [In Persian]
    34. Bizheh N, Abdollahi AR, Jaafari M, Ajam Zibad Z. Relationship between neck circumferences with cardiovascular risk factors. J Babol Univ Med Sci. 2011;13(1):36-43. [In Persian]