تاثیر هشت هفته تمرین مقاومتی دایره‌ای همراه با مکمل یاری آویشن بر مقادیر سرمی FGF-21 در زنان یائسه دارای اضافه وزن

نوع مقاله: مقاله پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

2 دانشیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

3 استادیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

چکیده

اگرچه یائسگی در افزایش وزن موثر است، اما تمرین ورزشی و استفاده از مکمل گیاهی آسیب‌های ناشی از اضافه وزن را به حداقل می‌رساند. هدف پژوهش حاضر بررسی تاثیر تمرینات مقاومتی دایره‌ای همراه با مکمل‌ یاری آویشن بر مقادیر سرمیFGF-21 زنان یائسه دارای اضافه وزن بود. 48 آزمودنی، با دامنه سنی 55 ـ 45 سال به طور تصادفی در چهار گروه 12 نفری کنترل، مکمل آویشن، ‌تمرین مقاومتی + دارونما و تمرین مقاومتی + مکمل ‌آویشن قرار گرفتند. پروتکل تمرین مقاومتی به مدت هشت هفته، سه روز در هفته با 35 % 1RM  اجرا شد. نمونه‌های خونی 48 ساعت قبل از شروع پروتکل تمرین و بعد از آخرین جلسه تمرینی اخذ شدند. مقادیر FGF-21 به روش الایزا اندازه‌گیری شد و تجزیه و تحلیل داده‌ها با آزمون تی همبسته و آنوا انجام شد. تنها در دو گروه تمرین مقاومتی و تمرین مقاومتی + آویشن مقادیر FGF-21 سرمی نسبت به پیش آزمون افزایش یافت(003/0=P). با توجه به نتایج پژوهش حاضر به نظر می‌رسد استفاده از مکمل گیاهی آویشن در کنار تمرین مقاومتی می تواند سبب افزایش مقادیر FGF-21 سرمی شود که یک روش موثر در کاهش چاقی و جوگیری از عوارض آن در زنان یائسه دارای اضافه وزن می باشد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Effects of eight-weeks of circuit resistance training with Thyme supplementation on serum FGF-21 in overweight menopausal women

نویسندگان [English]

  • Fatemeh Eskandar Pour 1
  • Asghar Tofighi 2
  • Javad Tolouei Azar 3
1 M.Sc. of exercise physiology, Urmia University, Urmia, Iran.
2 Associate professor of exercise physiology, Urmia University, Urmia, Iran.
3 Assistant professor of exercise physiology, Urmia University, Urmia, Iran.
چکیده [English]

Although menopause is effective in weight gain, however, exercise training and herbal supplementation minimizes the damage caused by excessive weight. The aim of this study was to investigate the effects of circuit resistance training with Thyme supplementation on serum levels of FGF-21 in postmenopausal overweight women. 48 subjects, age: 45-55 years, were randomly divided into four groups (n=12 in each group) including on control, thyme supplementation, resistance training+ placebo and resistance training + thyme supplementation groups. The resistance training protocol was performed for 8 weeks, three days / week at 35% of 1RM. Blood samples were taken from the venous vein 48 hours before the exercise protocol and after the last training session. FGF-21 was measured using ELISA method. Data were analyzed using t-test and ANOVA (p≤0.05). Only resistance training increased FGF-21 serum levels in resistance training and resistance training + thyme groups (p = 0.003). It seems that thyme supplementation, along with resistance training, can increase serum FGF-21 levels, which is an effective way to decrease obesity and prevent its related complications in overweight menopausal women.

کلیدواژه‌ها [English]

  • circuit resistance training
  • Thyme
  • FGF-21
  • Postmenopausal
  • Overweight
منابع
1. Ranjan S, Nasser JA, Fisher K. Prevalence and potential factors associated with overweight and obesity status in adults with intellectual developmental disorders. Journal of Applied Research in Intellectual Disabilities. 2018;31:29-38.
2. Giannini A, Caretto M, Genazzani A, Simoncini T. Menopause, Hormone Replacement Therapy (HRT) and Obesity. CURRENT RESEARCH IN DIABETES & OBESITY JOURNAL. 2018;7(1.)
3. Lambrinoudaki I, Armeni E, Tsoltos N. Weight and Body Composition Management After Menopause: The Effect of Lifestyle Modifications. Pre-Menopause, Menopause and Beyond: Springer; 2018. p. 153-61.
4. Jones EK, Jurgenson JR, Katzenellenbogen JM, Thompson SC. Menopause and the influence of culture: another gap for Indigenous Australian women? BMC women's health. 2012;12(1):43.
5. Al-Safi ZA, Polotsky AJ. Obesity and menopause. Best Practice & Research Clinical Obstetrics & Gynaecology. 2015;29(4):548-53.
6. Gohlke-Bärwolf C. Coronary artery disease–is menopause a risk factor? Basic research in cardiology. 2000;95(1):I77-I83.
7. Anand SS, Yi Q, Gerstein H, Lonn E, Jacobs R, Vuksan V, et al. Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease. Circulation. 2003;108(4):420-5.
8. Perry A, Wang X, Goldberg R, Ross R, Jackson L. Androgenic sex steroids contribute to metabolic risk beyond intra‐abdominal fat in overweight/obese black and white women. Obesity. 2013;21(8):1618-24.
9. Stachowiak G, Pertyński T, Pertyńska-Marczewska M. Metabolic disorders in menopause. Przeglad menopauzalny= Menopause review. 2015;14(1):59.
10. Mejhert N. Characterization of adipose factors regulated by body weight: Inst för medicin, Huddinge/Dept of Medicine, Huddinge; 2013.
11. Tyynismaa H, Raivio T, Hakkarainen A, Ortega-Alonso A, Lundbom N ,Kaprio J, et al. Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins. The Journal of Clinical Endocrinology & Metabolism. 2011;96(2):E351-E5.
12. Dushay J, Chui PC, Gopalakrishnan GS, Varela–Rey M ,
Crawley M, Fisher FM, et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology. 2010;139(2):456-63.
13. Reinehr T, Woelfle J, Wunsch R, Roth CL. Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis. The Journal of Clinical Endocrinology & Metabolism. 2012;97(6):2143-50.
14. Cuevas-Ramos D, Almeda-Valdés P, Meza-Arana CE, Brito-Córdova G, Gómez-Pérez FJ, Mehta R, et al. Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLoS One. 2012;7(5):e38022.
15. Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, et al. An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell metabolism. 2013;17(5):790-7.
16. Itoh N. FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases. Frontiers in endocrinology. 2014;5:107.
17. Mashili FL, Austin RL, Deshmukh AS, Fritz T, Caidahl K, Bergdahl K, et al. Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity. Diabetes/metabolism research and reviews. 2011;27(3):286-97.
18. Dostalova I, Haluzikova D, Haluzik M. Fibroblast growth factor: 21 a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus. Physiological research. 2009;58(1):1.
19. Kharitonenkov A, Wroblewski VJ, Koester A, Chen Y-F, Clutinger CK, Tigno XT, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology. 2007;148(2):774-81.
20. Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou Z-G, Liu F, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 2008;57(5):1246-53.
21. Baik CS, Brasky TM, Pettinger M, Luo J, Gong Z, Wactawski-Wende J, et al. Non-steroidal anti-inflammatory drug and aspirin use in relation to lung cancer risk among postmenopausal women. Cancer Epidemiology and Prevention Biomarkers. 2015:cebp. 1322.2014.
22. Yang SJ, Hong HC, Choi HY, Yoo HJ, Cho GJ, Hwang TG, et al. Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women. Clinical endocrinology. 2011;75(4):464-9.
23. Shekarchi M, Hajimehdipoor H, Saeidnia S, Gohari AR, Hamedani MP. Comparative study of rosmarinic acid content in some plants of Labiatae family. Pharmacognosy magazine. 2012;8(29):37.
24. Anvari M, Dashti M, Zeinali F, Hosseini-Bioki S. The Effect of Thyme (Zataria multiflora Boiss.) Decoction on
27  اثر مصرف مکمل زغال اخته و تمرین تناوبی با شدت بالا بر سطوح پلاسمایی فاکتورهای فیبرینولیزی زنان یائسه چاق غیر فعال
Pregnancy in Rats. Journal of Medicinal Plants. 2011;2(38):19-25.
25. Iravani M. Clinical effects of Zataria multiflora essential oil on primary dysmenorrhea. Journal of Medicinal plants. 2009;8(30):54-168.
26. Ocaña A, Reglero G. Effects of thyme extract oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on cytokine production and gene expression of oxLDL-stimulated THP-1-macrophages. Journal of obesity. 2012; 2012.
27. Khani M, Motamedi P, Dehkhoda MR, Nikukheslat SD, Karimi P. Effect of thyme extract supplementation on lipid peroxidation, antioxidant capacity, PGC-1α content and endurance exercise performance in rats. Journal of the international society of sports nutrition. 2017;14(1):11.
28. Saei-Dehkordi SS, Tajik H, Moradi M, Khalighi-Sigaroodi F. Chemical composition of essential oils in Zataria multiflora Boiss. from different parts of Iran and their radical scavenging and antimicrobial activity. Food and Chemical Toxicology. 2010;48(6):1562-7.
29. Ghanbari A, Tayebi SM. The Effect of a Single Session of Eccentric Resistance Exercise on Some Parameters of White Blood Cells. Annals of Applied Sport Science. 2013;1(4):17-26.
30. Tanimura Y, Aoi W, Takanami Y, Kawai Y, Mizushima K, Naito Y, et al. Acute exercise increases fibroblast growth factor 21 in metabolic organs and circulation. Physiological reports. 2016;4(12).
31. Morville T, Sahl RE, Trammell SA, Svenningsen JS, Gillum MP ,Helge JW, et al. Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans. JCI insight. 2018;3(15.)
32. Kim H-j, Song W. Resistance training increases fibroblast growth factor-21 and irisin levels in the skeletal muscle of Zucker diabetic fatty rats. Journal of exercise nutrition & biochemistry. 2017;21(3):50.
33. Besse-Patin A, Montastier E, Vinel C, Castan-Laurell I, Louche K, Dray C, et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. International journal of obesity. 2014;38(5):707.
34. Scalzo RL, Peltonen GL, Giordano GR, Binns SE, Klochak AL, Paris HL, et al. Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training. PloS one. 2014;9(3):e90696.
35. Chu L, Morrison KM, Riddell MC, Raha S, Timmons BW. Effect of 7 days of exercise on exogenous carbohydrate oxidation and insulin resistance in children with obesity. Applied Physiology, Nutrition, and Metabolism. 2018(ja.)
36. Moyers JS, Shiyanova TL, Mehrbod F, Dunbar JD, Noblitt TW, Otto KA, et al. Molecular determinants of FGF‐21 activity—synergy and cross‐talk with PPARγ signaling. Journal of cellular physiology. 2007;210(1):1-6.
37. Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, Rydén M. FGF21 attenuates lipolysis in human adipocytes–a possible link to improved insulin sensitivity. FEBS letters. 2008;582(12):1725-30.
38. Segsworth BM. Acute Sprint Interval Exercise Induces a Greater FGF-21 Response in Comparison to Work-Matched Continuous Exercise. 2015.
39. Basti AA, Gandomi H, Noori N, Khanjari A. Shirazi thyme (Zataria multiflora Boiss) Oils. Essential Oils in Food Preservation, Flavor and Safety: Elsevier; 2016. p. 731-6.
40. Hashemi SA, Azadeh S, Nouri BM, Alizade R. Review of Pharmacological Effects of Zataria multifloraBoiss.(Thyme of Shiraz). Health Sciences. 2017;6(8):78-84.
41. Mohammadi A, Gholamhoseinian A, Fallah H .Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats. Iranian journal of basic medical sciences. 2014;17(4):263.
42. Nik HA, Makki OF, Ebrahimzadeh A, Omidi A. Evaluation of blood chemical ,lipids profile and immune response on broiler chicks fed with milk thistle (Silybum mari-anum L.) and thyme (Thymus vulgaris L.) seeds in south-eastern Iran. Veterinary Science Development. 2014;5(1).
43. Choi JH, Kim SW, Yu R, Yun JW. Monoterpene phenolic compound thymol promotes browning of 3T3-L1 adipocytes. European journal of nutrition. 2017; 56(7):2329-41.