تأثیر یک جلسه تمرین مقاومتی بر سطوح سرمی آدیپولین و برخی عوامل تنظیم کنندة آن در زنان چاق و غیرفعال

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دکتری فیزیولوژی ورزشی، دانشگاه آزاد اسلامی، واحد بجنورد، بجنورد، ایران

2 دکتری فیزیولوژی ورزشی، دانشکده تربیت‌بدنی دانشگاه تهران

چکیده

بافت چربی یک ارگان اندوکرین فعال است که به‌واسطۀ ترشح آدیپوکاین­ها در تنظیم شرایط متابولیکی بدن نقشی اساسی دارد. هدف مطالعۀ حاضر مطالعه تأثیر یک جلسه تمرین مقاومتی بر سطوح آدیپولین، فورین، فاکتور رشد تغییردهندۀ بتا 1، فاکتور نکروز کنندۀ تومور آلفا و شاخص مقاومت به انسولین در زنان چاقِ غیرفعال پرداخته است. بدین منظور 20 زن چاقِ یائسۀ غیرفعال (شاخص تودۀ بدنی>30 کیلوگرم بر مترمربع، 65-50 سال) به­طور تصادفی به دو گروه تجربی (12 نفر) و کنترل (8 نفر) تقسیم شدند. گروه تجربی در یک جلسه تمرین مقاومتی (سه دوره با 8 تکرار درشدت 40 درصد یک تکرار بیشینه) به مدت 30 دقیقه شرکت کردند. سطوح آدیپولین، فورین، فاکتور رشد تغییردهندۀ بتا 1، فاکتور نکروز کنندۀ تومور آلفا، انسولین، گلوکز و شاخص­های آنتروپومتری قبل و بلافاصله بعد از جلسۀ تمرین اندازه­گیری شدند. تجزیه‌وتحلیل داده­ها با آزمون تی زوجی، تی مستقل و آزمون همبستگی پیرسون در سطح معناداری 05/0>P انجام گرفت. نتایج نشان داد اجرای یک جلسه تمرینات مقاومتی موجب افزایش معنادار سطوح فورین شد اما تغییر معناداری در سطوح آدیپولین، فاکتور رشد تغییردهندۀ بتا 1، فاکتور نکروز کنندۀ تومور آلفا، انسولین، گلوکز و شاخص مقاومت به انسولین مشاهده نگردید. بااین‌حال، تنها تغییرات آدیپولین بین دو گروه تجربی و کنترل معنادار بود. هم­چنین، بین سطوح اولیۀ آدیپولین سرم باارزش‌های اولیۀ شاخص­های آنتروپومتری و سطوح اولیۀ انسولین، گلوکز ناشتا و شاخص مقاومت به انسولین، ارتباط معناداری وجود نداشت؛ اما پس از یک جلسه تمرین مقاومتی بین تغییرات آدیپولین با تغییرات شاخص مقاومت به انسولین ارتباط معنادار و مثبتی گزارش شد. به‌طورکلی می­توان نتیجه گرفت اجرای یک جلسه تمرین مقاومتی در زنان چاق یائسۀ غیرفعال بر سطوح آدیپولین تأثیر نداشته و این پاسخ تا حدودی با تغییرات نیم­رخ التهابی و متابولیکی هم­سو هست.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Effect of one session of resistance training on serum levels of adipolin and some factors regulating adipolin in sedentary obese women

نویسندگان [English]

  • Najmeh Rezaeian 1
  • Ali Asghar Ravasi 2
  • Rahman Souri 2
  • Ali Akbarnezhad 2
1 Islamic Azad University, Bojnourd branch, Bojnourd, Iran
2 Faculty of Sports and Exercise Sciences, University of Tehran.
چکیده [English]

Adipose tissue as an active endocrine organ has a pivot role in regulating metabolic states of the body, via secretion of pre- and anti- inflammatory adipokines. This study investigated effect of one session of resistance training on levels of adipolin, furin, transforming growth factor β1, tumor necrosis factor-α and insulin resistance in sedentary obese women. For this purpose 20 sedentary postmenopausal obese women (BMI>30Kg/m2, aged 50-65 years) randomly assigned in to experimental (n=12) and control (n=8) groups. Subjects in experimental group participated in one session of resistance training (2 sets of 8 repetitions at 40% of one-repetition maximum for 30 minutes). Serum levels of adipolin, furin, transforming growth factor β1, tumor necrosis factor-α, insulin and fasting glucose measured before and immediately after training session. Statistical analysis was done by paired and independent t-test and Pearson correlation and P 

کلیدواژه‌ها [English]

  • Adipolin
  • Furin
  • Transforming Growth Factor β1
  • Tumor Necrosis Factor-α
  • resistance training
Akima H, Takahashi H, Kuno SY, Masuda K, Masuda T, Shimojo H, Anno I, Itai Y, Katsuta S. (1999) "Early phase adaptations of muscle use and strength to isokinetic training". Med Sci Sports Exerc. 31(4):588-94. (PMID: 10211857)
Arsenault BJ, Côté M, Cartier A, Lemieux I, Després JP, Ross R, Earnest CP, Blair SN, Church TS. (2009) "Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure". Atherosclerosis. 207(2):530-3. (PMID: 19524243)
Baecke JAH, Burema J, Frijters JER. (1982) "A short questionnaire for the measurement of habitual physical activity in epidemiological studies". Am J Clin Nutr. 36(5): 936-42. (PMID: 7137077)
Blanchette F, Dong RW, Laprise MH, Dubois CM. (1997) "TGFb1 Regulates Gene Expression of Its Own Converting Enzyme Furin". J Clin Invest. 99:1974–83. (PMCID: PMC508022)
Bouchard DR, Soucy L, Sénéchal M, Dionne IJ, Brochu M. (2009) "Impact of resistance training with or without caloric restriction on physical capacity in obese older women". Menopause. 16(1):66-72. (PMID: 18779759)
Cigolini M, Tonoli M, Borgato L, Frigotto L, Manzato F, Zeminian S, Cardinale C, Camin M, Chiaramonte E, De Sandre G, Lunardi C. (1999) "Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF-alpha?" Atherosclerosis. 143(1). 81-90. (PMID: 10208482)
Calderone A, Murphy RJL, Lavoie J, Colombo F, Béliveau L. (2001) "TGF-β1 and prepro-ANP mRNAs are differentially regulated in exercise-induced cardiac hypertrophy". J App Physiol. 91: 771-6. (PMID: 11457793)
Calle MC, Fernandez ML. (2010) "Effects of resistance training on the inflammatory response". Nutr Res Pract. 4(4):259-69. (PMID: 20827340
Chua SD, Messier SP, Legault C, Lenz ME, Thonar EJMA, Loeser RF. (2008) "Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee". Osteoarthritis Cartilage. 16(9): 1047–53. (PMID: 18359648)
Dideriksen K, Sindby AKR, Krogsgaard M, Schjerling P, Holm L, Langberg H. (2013) "Effect of acute exercise on patella tendon protein synthesis and gene expression". Springer plus. 2(1):109. (PMID: 23586004)
Dubois CM, Laprise MH, Blanchette F, Gentry LE, Leduc R. (1995) "Processing of transforming growth factor beta 1 precursor by human furin convertase". J Biol Chem. 270: 10618–24. (PMID: 7737999)
Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N. (2011) "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J Biol Chem. 286(40): 34552–8. (PMID: 21849507)
Enomoto T, Shibata R, Ohashi K, Kambara T, Kataoka Y, Uemura Y, Yuasa D, Murohara T, Ouchi N. (2012) "Regulation of adipolin/CTRP12 cleavage by obesity". Biochem Biophys Res Commun. 428(1):155-9. (PMID: 23068097)
Fairey AS, Courneya KS, Field CJ, Bell GJ, Jones LW, Mackey JR. (2005) "Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors". J Appl Physiol (1985). 98(4):1534-40. (PMID: 15772062)
Gnacińska M, Małgorzewicz S, Stojek M, Łysiak-Szydłowska W, Sworczak K. (2009) "Role of adipokines in complications related to obesity: a review". Adv Med Sci. 54(2):150-7. (PMID: 19875356).
Gordon KJ, Blobe GC. (2008) "Role of transforming growth factor-β superfamily signaling pathways in human disease". Biochimica et Biophysica Acta. 1782: 197–228. (PMID: 18313409)
Hamada K, Vannier E, Sacheck JM, Witsell AL, Roubenoff R. (2005) "Senescence of human skeletal muscle impairs the local inflammatory cytokine response to acute eccentric exercise". FASEB J. 19(2):264-6. (PMID: 15556970)
Heinemeier KM, Olesen JL, Haddad F, Langberg H, jaer MK, Baldwin KM, Schjerling P. (2007) "Expression of collagen and related growth factors in rat tendon and skeletal muscle in response to specific contraction types". J Physiol. 582(Pt 3): 1303–16. (PMID: 17540706)
Heinemeier KM, Bjerrum SS, Schjerling P, Kjaer M. (2013) "Expression of extracellular matrix components and related growth factors in human tendon and muscle after acute exercise". Scand J Med Sci Sports. 23(3):e150-61. (PMID: 22107086)
Hunter M. (2000) "The women’s health questionnaire (WHQ): The development, standardization and application of a measure of mid-aged women's emotional and physical health". Qual life res. 9(Supp1): 733-8.
Jackson A S, Pollock ML, Ward A. (1980) "Generalized equations for predicting body density of women". Med Sci Sports Exerc. 12: 175-182. (PMID: 7402053)
Kanaley JA, Sames C, Swisher L, Swick AG, Ploutz-Snyder LL, Steppan CM, Sagendorf KS, Feiglin D, Jaynes EB, Meyer RA, Weinstock RS. (2001) "Abdominal fat distribution in pre- and postmenopausal women: The impact of physical activity, age, and menopausal status". Metabolism. 50(8):976-82. (PMID: 11474488)
Kannel WB, Sorlie P. (1979) "Some health benefits of physical activity: the Framingham Study". Arch Intern Med. 139(8): 857–61. (PMID: 464698)
Khadivi Borujeny A, Marandi M, Haghjooy Javanmard Sh, Rajabi H, Khadivi Borujeny Z, Khorshidi Behzadi M. (2012) "Effect of Eight Weeks of Resistance Training on Some Signaling Factors Affecting on the Satellite Cells in Wistar Rats". Journal of Isfahan Medical School. 3(207): 1-12.
Kodama S, Mia S, Yamada N, Sone H. (2006) "Exercise Training for Ameliorating Cardiovascular Risk Factors-focusing on Exercise Intensity and Amount". Int J Sport Health Sci. 4: 325-38.
Kondo T, Kobayashi I, Murakami M. (2006) "Effect of exercise on circulating adipokine levels in obese young women". Endocr J. 53(2):189-95. (PMID: 16618976)
Lau DC, Douketis JD, Morrison KM, Hramiak IM, Sharma AM, Ur E. (2007) "2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]". Cmaj. 176(8): S1-13. (PMID: 17420493)
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. (1985) "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man". Diabetologia. 28 (7): 412–9. (PMID: 3899825)
Maud PJ, Foster C. (2006) "Physiological assessmnet of human fitness". 2nd ed. Canada: Human Kinetics.
Montazri Taleghani H, Soori R, Rezaeian N, Khosravi N. (2012) "Changes in leptin and adiponectin of plasma in response to combined endurance and resistance training in sedentary postmenopausal women". Koomesh. 13 (2): 269-77.
Nardo LG, Rai R. (2001) "Metformin therapy in the management of polycystic ovary syndrome: endocrine, metabolic and reproductive effects. Gynecol Endocrinol. 15: 373–80. (PMID: 11727360)
Nieman DC, Brock DW, Butterworth D, Utter AC, Nieman CC. (2002) "Reducing diet and/or exercise training decreases the lipid and lipoprotein risk factors of moderately obese women". J Am Coll Nutr. 21(4):344-50. (PMID: 12166532)
Olson TP, Dengel DR, Leon AS, Schmitz KH. (2007) "Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women". Int J Obes (Lond). 31(6):996-1003. (PMID: 17299382)
Ouchi N, Parker JL, Lugus JJ, Walsh K. (2011) "Adipokines in inflammation and metabolic disease". Nat Rev Immunol. 11(2): 85–97. (PMCID: PMC3518031)
Pedersen BK, Bruunsgaard H, Ostrowski K, Krabbe K, Hansen H, Krzywkowski K, Toft A, Søndergaard SR, Petersen EW, Ibfelt T, Schjerling P. (2000) "Cytokines in aging and exercise". Int J Sports Med. 21 Suppl 1:S4-9. (PMID: 10893017)
Petersen AM, Pedersen BK. (2006) "The role of IL-6 in mediating the anti-inflammatory effects of exercise". J Physiol Pharmacol. 57 Suppl 10:43-51. (PMID: 17242490)
Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. (2012) "Resistance training reduces subclinical inflammation in obese, postmenopausal women". Med Sci Sports Exerc. 44(11):2099-110. (PMID: 22874536)
Polak J, Klimcakova E, Moro C, Viguerie N, Berlan M, Hejnova J, Richterova B, Kraus I, Langin D, Stich V. (2006) "Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women". Metabolism. 55(10):1375-81. (PMID: 16979409)
Raastad T, Bjøro T, Hallén J. (2000) "Hormonal responses to high- and moderate-intensity strength exercise". Eur J Appl Physiol. 82(1-2):121-8. (PMID: 10879453)
Ryan AS, Treuth MS, Hunter GR, Elahi D. (1998) "Resistive training maintains bone mineral density in postmenopausal women". Calcif Tissue Int. 62(4):295-9. (PMID: 9504952)
Schlöndorff BJ, Blobel CP. (2000) "Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE)". Biochem J. 138: 131–8. (PMID: 10727411)
Siezen RJ, Leunissen JAM. (1997) "Subtilases:The superfamily of subtilisin-like serine proteases". Protein Sci. 6: 501–23. (PMID: 9070434)
Siri WE. (1993) "Body composition from fluid spaces and density: analysis of methods". 1961. Nutrition. 9(5):480-91. (PMID: 8286893)
Skurk T, Birgel M, Lee YM, Hauner H. (2006) "Effect of troglitazone on tumor necrosis factor alpha and transforming growth factor beta expression and action in human adipocyte precursor cells in primary culture". Metabolism. 55(3):309-16. (PMID: 16483873)
Soori R, Rezaeian N, Khosravi N. (2012) "10 weeks of resistance training does not effect on serum concentration of Pre-B cell colony-enhancing factor/Visfatin in middle- aged obese women". Research in Sports Sciences. 12: 59-75.
Stawowy P, Fleck E. (2005) "Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels". J Mol Med (Berl). 83(11):865-75. (PMID: 16244876)
Tan BK, Chen J, Adya R, Ramanjaneya M, Patel V, Randeva HS. (2013) "Metformin increases the novel adipokine adipolin/CTRP12: role of the AMPK pathway". J Enocrinol. 219(2): 101-8. (PMID: 23946431)
Tan BK, Chen J, Hu J, Amar O, Mattu HS, Ramanjaneya M, Patel V, Lehnert H, Randeva HS. (2014) "Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oralglucose challenge in human". Clin Endocrinol (Oxf). 81(6):841-6. (PMID: 24612181)
Thomas G. (2002) "Furin at the cutting edge: from protein traffic to embryogenesis and disease". Nat Rev Mol Cell Biol. 3(10):753-66. (PMID: 12360192)
Tidball JG. (2005) "Inflammatory processes in muscle injury and repair". Am J Physiol Regul Integr Comp Physiol. 288(2):R345-53. (PMID: 15637171)
Trapp EG, Chisholm DJ, Freund J, Boutcher SH. (2008) "The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women". Int J Obes (Lond). 32(4): 684–91. (PMID: 18197184)
Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, Wong GW. (2012) "C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes". J Biol Chem. 287: 10301–15. (PMID: 22275362)
Wei Z, Lei X, Seldin MM, Wong GW. (2012) "Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity". J Biol Chem. 287(43):35804-14. (PMID: 22942287)
Wei Z, Lei X, Seldin MM, Wong GW. (2012) "Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity". J Biol Chem. 287(43):35804-14. (PMID: 22942287)
Wojtaszewski JF, Nielsen JN, Richter EA. (2002) "Invited review: effect of acute exercise on insulin signaling and action in humans". J Appl Physiol (1985). 93(1):384-92. (PMID: 12070228)
Wong GW, Wang J, Hug C, Tsao TS, Lodish HF. (2004) "A family of Acrp30/adiponectin structural and functional paralogs". Proc Natl Acad Sci USA. 101(28):10302-7. (PMID: 15231994)
Wozniak SE, Gee LL, Wachtel MS, Frezza EE. (2009) "Adipose tissue: the new endocrine organ? A review article". Dig Dis Sci. 54(9):1847-56. (PMID: 19052866)
Wu S, Liang S, Yan Y, Wang Y, Li F, Deng Y, Huang W, Yuan W, Luo N, Zhu C, Wang Y, Li Y, Liu M, Wu X. (2007) "A novel mutation of TGF beta1 in a Chinese family with Camurati-Engelmann disease". Bone. 40(6):1630-4. (PMID: 17433803)
Yang Y, Jemiolo B, Trappe S. (2006) "Proteolytic mRNA expression in response to acute resistance exercise in human single skeletal muscle fibers". J Appl Physiol (1985). 101(5):1442-50. (PMID: 16840578)
Zettl AM, Taylor CN, Freeman M. (2012) "Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE". Science. 335: 225–8. (PMID: 22246777)