نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
1 گروه فیزیولوژی ورزشی - دانشکده ادبیات و علوم انسانی دانشگاه قم – ایران
2 ، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی دانشگاه قم –قم- ایران
3 گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی دانشگاه قم –قم- ایران
4 گروه علوم ورزشی. دانشکده ادبیات و علوم انسانی دانشگاه قم –قم- ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background& purpose Today, kidney damage is one of the global health challenges. The overall objective is to compare the effect of a period of aerobic exercise and supplementation with hydroalcoholic extract of date palm on the expression of Mir-141, Mir-143, and Mir-223 in kidney tissue induced by cadmium chloride in male rats. Method: In this experimental study, 48 healthy adult male Wistar rats with a weight range of 250±30 g and an age of 12 weeks were studied. The rats were randomly divided into 6 groups: intact (healthy), control, cadmium chloride, exercise, palm pollen 200, and palm pollen 400. To induce renal damage, they received cadmium chloride at a dose of 3 mg/kg body weight (diluted with distilled water) daily by gavage. Aerobic exercise consisted of running on a treadmill at a speed of 27 m/min, and one minute was added to the exercise daily. The rats were anesthetized with diethyl ether, and the kidney tissue was removed by making an incision in the abdominal area and transferred to the laboratory for measurement of variables. Results: In kidney tissue, there was a significant difference in the expression of Mir-141 (P=0.001), Mir-143 (P=0.013), and Mir-223 (P=0.001) genes between the research groups. The results of the post hoc test also showed that exercise led to a significant increase in the expression of Mir-141 and Mir-223 genes and a significant decrease in Mir-143 in kidney tissue. Conclusion: Cadmium reduced the expression of Mir-143, Mir-223 and Mir-141 genes in the kidney tissue of mice, but aerobic exercise and consumption of hydroalcoholic extract of palm pollen were able to neutralize the effects of cadmium on the factors, increase their expression and provide homeostasis conditions in the kidney tissue.
کلیدواژهها [English]
)