مقایسه اثر فعالیت ورزشی زیربیشینه با و بدون مصرف کافئین بر سطوح آلفا آمیلاز، لپتین، شاخص‌های گلایسمی و انرژی دریافتی در افراد چاق و اضافه وزن

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 کارشناسی ارشد فیزیولوژی ورزشی، گروه فیزولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه صنعتی شاهرود، سمنان، ایران

2 گروه تربیت بدنی و علوم ورزشی، دانشکده تربیت بدنی دانشگاه صنعتی شاهرود، شاهرود، ایران.

10.22049/jahssp.2023.29001.1588

چکیده

هدف: هدف از تحقیق حاضر، مقایسه اثر فعالیت زیر بیشینه با و بدون مصرف مکمل کافئین بر آلفا آمیلاز سرم، گلوکز خون، انسولین، لپتین و دریافت انرژی در افراد چاق و دارای اضافه وزن بود. روش شناسی: تحقیق حاضر به صورت متقاطع تصادفی شده با 16 نفر آزمودنی داوطلب مرد و زن چاق با رده سنی بالای 18 سال شاخص توده‌ی بدنی (BMI) بیشتر از 25 کیلوگرم بر متر مربع انجام شد. آزمودنی‌ها به صورت تصادفی در دو وضعیت: فعالیت زیر بیشینه با مصرف مکمل کافئین، فعالیت زیر بیشینه بدون مصرف مکمل کافئین (دارونما) قرار گرفتند. یک دوز کپسول کافئین 200 میلی‌گرم و پودر نشاسته توسط آزمودنی‌ها دریافت شده و 60 دقیقه پس از آن به انجام فعالیت ورزشی شدت 60 درصد ضربان قلب ذخیره به مدت 30 دقیقه پرداختند. نمونه‌های خونی قبل و بعد از مصرف مکمل و بعد از فعالیت ورزشی جمع‌آوری شد. داده ها با استفاده از آزمون تحلیل واریانس مکرر تحلیل شد. یافته­ها: کافئین باعث افزایش قند خون، انسولین و آلفا آمیلاز سرم شد (05/0p <) و فعالیت ورزشی باعث کاهش معنادار آلفا آمیلاز سرم، گلوکز و انسولین و افزایش لپتین شد (05/0p <). کاهش انسولین و قند خون در پاسخ به فعالیت ورزشی، با مصرف کافئین بیشتر از دارونما بود (05/0p <). با این‌حال، کافئین تاثیر معنادار بر لپتین و پاسخ آن به فعالیت ورزشی نداشت (05/0p >). نتیجه گیری:  اگرچه پاسخ شاخص‌های متابولیک به فعالیت ورزشی تحت تاثیر کافئین قرار گرفت اما بنظر نمی‌رسد کافئین بر هورمون‌ موثر در اشتهای لپتین و دریافت غذایی متعاقب فعالیت ورزشی تاثیرگذار باشد. بنابراین، دریافت انرژی بعد از فعالیت ورزشی صرفنظر از مصرف کافئین افزایش می‌یابد که باید در کنترل وزن افراد چاق مورد توجه باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Comparison of the effect of submaximal exercise with and without caffeine consumption on alpha-amylase, leptin, glycemic indices and energy intake in obese and overweight people

نویسندگان [English]

  • Zeynab karimzadeh 1
  • Farhad Gholami 2
  • Fateme Sheykhpour 1
1 MSc of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Shahrood University of Technology, Semnan, Iran.
2 Department of Physical Education and Sport Sciences, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Iran.
چکیده [English]

Aim:      The aim of this study was to compare the effects of maximal exercise with and without caffeine supplementation on serum alpha-amylase, blood glucose, insulin, leptin, and energy intake in overweight or obese individuals. Materials and methods:  This crossover study was conducted on 16 overweight or obese male and female volunteers aged over 18 years with a body mass index (BMI) > 25 kg/m2. Participants were randomly assigned into two conditions: maximal exercise with caffeine supplementation and maximal exercise without placebo supplementation. Participants received a dose of 200 mg caffeine capsule and starch powder and then performed 30 minutes of submaximal exercise at 60% of HRR. Blood samples were collected before and after caffeine supplementation and following exercise. The data were analyzed using repeated-measures ANOVA. Result: caffeine increased blood glucose, insulin, and serum alpha-amylase (p < 0.05). Exercise significantly decreased serum alpha-amylase, insulin and blood glucose levels and increased leptin levels (p < 0.05). The change in insulin and blood glucose levels in response to exercise were greater with caffeine supplementation than with placebo (p < 0.05). However, caffeine had no significant effect on leptin levels or its response to exercise (p > 0.05). Conclusion: Although caffeine affected metabolic responses to exercise, it has no effect on appetite hormone leptin and subsequent food intake. Energy intake seemingly increases following exercise regardless of caffeine consumption, which should be considered in weight management.

کلیدواژه‌ها [English]

  • serum alpha-amylase
  • blood glucose
  • obesity
  • energy intake
  • insulin

مراجع

  1. Zaharieva D, Miadovnik L, Rowan C, Gumieniak R, Jamnik V, Riddell M. Effects of acute caffeine supplementation on reducing exercise‐associated hypoglycaemia in individuals with Type 1 diabetes mellitus. Diabetic Medicine. 2016;33(4):488-96.
  2. Trice I, Haymes EM. Effects of caffeine ingestion on exercise-induced change during high-intensity intermittent exercise. International Journal of Sport Nutrition and Exercise Metabolism. 1995;5(1):37-44.
  3. Jamali Qarakhanlou B. The effect of four weeks caffeine supplementation with concurrent training on glycemic markers and insulin resistance in serum of girls with overweight. Complementary Medicine Journal. 2017;7(3):1944-57.
  4. Lippi G, Salvagno GL, Danese E, Tarperi C, La Torre A, Guidi GC, et al. The baseline serum value of α-amylase is a significant predictor of distance running performance. Clinical Chemistry and Laboratory Medicine (CCLM). 2015;53(3):469-76.
  5. da Silva Rolim P, da Costa Matos RA, Von Koenig Soares EdMK, Molina GE, da Cruz CJG. Caffeine increases parasympathetic reactivation without altering resting and exercise cardiac parasympathetic modulation: A balanced placebo design. European Journal of Sport Science. 2019;19(4):490-8.
  6. Dewar L, Heuberger R. The effect of acute caffeine intake on insulin sensitivity and glycemic control in people with diabetes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2017;11:S631-S5.
  7. Bassami M, Ahmadizad S, Rahmani H, Khodamoradi A. The Effect of Resistance Exercise Intensity on Plasma Visfatin Levels and Its Relationship with Insulin Resistance and Related Hormones. Journal of Sport Biosciences. 2015;7(1):31-44.
  8. Karimnezhad N, Mahdavi Roshan M, Izaddost F, Shabani R. The simultaneous effects of green coffee and combine exercise training on body composition and glucose homeostasis in obese and overweight women. Journal of Medicinal Plants. 2019;18(72):215-27.
  9. Gourcerol G, Coskun T, Craft LS, Mayer JP, Heiman ML, Wang L, et al. Preproghrelin‐derived peptide, obestatin, fails to influence food intake in lean or obese rodents. Obesity. 2007;15(11):2643-52.
  10. Azarbaijani M, ALIPOUR S, BAKHSHANDEH H, REZAEIAN S, Tojari F. The relation between daily physical activity and obesity in 11-year old girls. 2009.
  11. Zarineh F, Avandi SM, Ebrahimi M. The effect of eight weeks high-intensity interval training with milk supplementation on Appetite and Body Composition in obese women. Journal of Applied Health Studies in Sport Physiology. 2017;4(1):82-90.
  12. Hagobian TA, Yamashiro M, Hinkel-Lipsker J, Streder K, Evero N, Hackney T. Effects of acute exercise on appetite hormones and ad libitum energy intake in men and women. Applied Physiology, Nutrition, and Metabolism. 2013;38(999):66-72.
  13. Dray C, Daviaud D, Guigné C, Valet P, Castan-Laurell I. Caffeine reduces TNFα up-regulation in human adipose tissue primary culture. Journal of physiology and biochemistry. 2007;63:329-36.
  14. Ruhl CE, Everhart JE. Leptin concentrations in the United States: relations with demographic and anthropometric measures. The American journal of clinical nutrition. 2001;74(3):295-301.
  15. Ruhl CE, Everhart JE, Ding J, Goodpaster BH, Kanaya AM, Simonsick EM, et al. Serum leptin concentrations and body adipose measures in older black and white adults. The American journal of clinical nutrition. 2004;80(3):576-83.
  16. Mantzoros CS, Moschos SJ. Leptin: in search of role (s) in human physiology and pathophysiology. Clinical endocrinology. 1998;49(5):551-67.
  17. Fried SK, Ricci MR, Russell CD, Blandine L. Symposium: Adipocyte function, differentiation and metabolism. J Nutr. 2000;130:3127S-31S.
  18. Blum WF, Englaro P, Attanasio AM, Kiess W, Rascher W. Human and clinical perspectives on leptin. Proceedings of the Nutrition Society. 1998;57(3):477-85.
  19. Kuczmarski RJ. Leptin concentrations in US adults. Oxford University Press; 2001. p. 277-8.
  20. Abaassi Daluee A, Ghanbari Niaki A, Fathi R, Hedayati M. The Effect of a Single Session Aerobic Exercise on Plasma Ghrelin, GH, Insulin and Cortisol in Non-Athlete University Male Students. Iranian Journal of Endocrinology and Metabolism. 2011;13(2):197-201.
  21. Khorshidi D, Azizbeigi K, Abedi B. Effect of progressive aerobic training on leptin, insulin, cortisol and testosterone in obese sedentary men. Scientific Journal of Kurdistan University of Medical Sciences. 2014;19(4):118-27.
  22. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269(5223):546-9.
  23. Kusminski CM, Bickel PE, Scherer PE. Targeting adipose tissue in the treatment of obesity-associated diabetes. Nature reviews Drug discovery. 2016;15(9):639-60.
  24. Agarwal P, Gupta R. Alpha-amylase inhibition can treat diabetes mellitus. Res Rev J Med Health Sci. 2016;5(4):1-8.
  25. Mahmood N. A review of α-amylase inhibitors on weight loss and glycemic control in pathological state such as obesity and diabetes. Comparative Clinical Pathology. 2016;25(6):1253-64.
  26. Khalil-Moghaddam S, Ebrahim-Habibi A, Pasalar P, Yaghmaei P, Hayati-Roodbari N. Reflection on design and testing of pancreatic alpha-amylase inhibitors: an in silico comparison between rat and rabbit enzyme models. DARU Journal of Pharmaceutical Sciences. 2012;20:1-9.
  27. Nakajima K. Low serum amylase and obesity, diabetes and metabolic syndrome: A novel interpretation. World journal of diabetes. 2016;7(6):112.
  28. Sweeney P, Levack R, Watters J, Xu Z, Yang Y. Caffeine increases food intake while reducing anxiety-related behaviors. Appetite. 2016;101:171-7.
  29. Liu AG, Smith SR, Fujioka K, Greenway FL. The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss. Obesity. 2013;21(10):1991-6.
  30. Rasaei B, Karim NA, Abd Talib R, Noor IM, Karandish M. The effect of simultaneous consumption of coffee caffeine and sleep deprivation on plasma ghrelin and leptin levels. Int J Nutr Sci June. 2019;4(2):88-96.
  31. Wu L, Meng J, Shen Q, Zhang Y, Pan S, Chen Z, et al. Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice. Nature communications. 2017;8(1):15904.
  32. Schubert MM, Irwin C, Seay RF, Clarke HE, Allegro D, Desbrow B. Caffeine, coffee, and appetite control: a review. International journal of food sciences and nutrition. 2017;68(8):901-12.
  33. Petridou A, Siopi A, Mougios V. Exercise in the management of obesity. Metabolism. 2019;92:163-9.
  34. Balaguera-Cortes L, Wallman KE, Fairchild TJ, Guelfi KJ. Energy intake and appetite-related hormones following acute aerobic and resistance exercise. Applied Physiology, Nutrition, and Metabolism. 2011;36(6):958-66.
  35. Oh D-H, Lee J-K. Effect of Different Intensities of Aerobic Exercise Combined with Resistance Exercise on Body Fat, Lipid Profiles, and Adipokines in Middle-Aged Women with Obesity. International Journal of Environmental Research and Public Health. 2023;20(5):3991.
  36. Damirchi A, Rahmani-Nia F, Mirzaie B, Hasan-Nia S, Ebrahimi M. Effect of caffeine on metabolic and cardiovascular responses to submaximal exercise in lean and obese men. Biomedical Human Kinetics. 2009;1(2009):31-5.
  37. Dorling J, Broom DR, Burns SF, Clayton DJ, Deighton K, James LJ, et al. Acute and chronic effects of exercise on appetite, energy intake, and appetite-related hormones: the modulating effect of adiposity, sex, and habitual physical activity. Nutrients. 2018;10(9):1140.
  38. Bérubé-Parent S, Pelletier C, Doré J, Tremblay A. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. British Journal of Nutrition. 2005;94(3):432-6.
  39. Spriet LL. Exercise and sport performance with low doses of caffeine. Sports medicine. 2014;44:175-84.
  40. Titlow LW, Ishee JH, Riggs CE. Failure of caffeine to affect metabolism during 60 min submaximal exercise. Journal of sports sciences. 1991;9(1):15-22.
  41. Lahman K. The Effect of Caffeine on a Submaximal Exercise Bout. 2017.
  42. Klein LC, Whetzel CA, Bennett JM, Ritter FE, Nater UM, Schoelles M. Caffeine administration does not alter salivary α-amylase activity in young male daily caffeine consumers. BMC research notes. 2014;7:1-6.
  43. Lee S, Hudson R, Kilpatrick K, Graham TE, Ross R. Caffeine ingestion is associated with reductions in glucose uptake independent of obesity and type 2 diabetes before and after exercise training. Diabetes Care. 2005;28(3):566-72.
  44. Iriondo-DeHond A, Uranga JA, Del Castillo MD, Abalo R. Effects of coffee and its components on the gastrointestinal tract and the brain–gut axis. Nutrients. 2020;13(1):88.
  45. Paluska SA. Caffeine and exercise. Current sports medicine reports. 2003;2(4):213-9.
  46. Bottoms L, Westhead R, Evans J, Blyth J, Sleet T, Sinclair J. The effects of carbohydrate ingestion on 30 minute rowing time trial performance. Comparative Exercise Physiology. 2014;10(4):247-52.
  47. Desbrow B, Biddulph C, Devlin B, Grant GD, Anoopkumar-Dukie S, Leveritt MD. The effects of different doses of caffeine on endurance cycling time trial performance. Journal of sports sciences. 2012;30(2):115-20.
  48. Darakjian LI, Kaddoumi A. Physiologically based pharmacokinetic/pharmacodynamic model for caffeine disposition in pregnancy. Molecular pharmaceutics. 2019;16(3):1340-9.
  49. Apostolidis A, Mougios V, Smilios I, Frangous M, Hadjicharalambous M. Caffeine supplementation is ergogenic in soccer players independent of cardiorespiratory or neuromuscular fitness levels. Journal of the International Society of Sports Nutrition. 2020;17(1):31.
  50. Martins C, Stensvold D, Finlayson G, Holst J, Wisloff U, Kulseng B, et al. Effect of moderate-and high-intensity acute exercise on appetite in obese individuals. Medicine and Science in Sports and Exercise. 2015;47(1):40-8.
  51. Azarbayjani MA, Fatolahi H, Rasaee MJ, Peeri M, Babaei R. The effect of exercise mode and intensity of sub-maximal physical activities on salivary testosterone to cortisol ratio and α-amylase in young active males. International journal of exercise science. 2011;4(4):283.
  52. Ameri M, Ghazalian F, Shakeri N, Akhoond MR. Effect of exercise with mental stress on cortisol and alpha-amylase changes in young men. Middle East Journal of Rehabilitation and Health Studies. 2020;7(1).
  53. Pajcin M, White JM, Banks S, Dorrian J, Paech GM, Grant CL, et al. Effects of strategic early-morning caffeine gum administration on association between salivary alpha-amylase and neurobehavioural performance during 50 h of sleep deprivation. Accident Analysis & Prevention. 2019;126:160-72.
  54. Simental-Mendía LE, Simental-Mendía M, Ríos-Mier M. Effects of Coffee Supplementation on Homocysteine and Leptin Levels: A Systematic Review and Meta-analysis of Clinical Trials. Current Pharmaceutical Design. 2023;29(1):30-6.
  55. IRANDOOST H, Siahkuhian M, Sadeghi A. The effects of specific aerobic exercise on leptin serum in athletes men. Journal of Applied Health Studies in Sport Physiology. 2017;4(1):68-73.
  56. Shahidi F, Pirhadi S. The effect of physical exercise and training on serum leptin levels. Razi J Med Sci. 2014;21(126):1-14.
مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 11، شماره 1
فروردین 1403
صفحه 208-222

فایل ها

سابقه مقاله

  • تاریخ دریافت: 28 شهریور 1402
  • تاریخ بازنگری: 15 آبان 1402
  • تاریخ پذیرش: 26 آبان 1402

هم رسانی

ارجاع به این مقاله

آمار