تأثیر تمرینات ترکیبی بر سطح سرمی کینزین-1 و عملکرد فیزیکی در مردان سالمند مبتلا به دیابت نوع 2

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I


1 دانشجوی کارشناسی ارشد، دانشکده علوم انسانی، دانشگاه البرز، آبیک ،ایران

2 دکترای فیزیولوژی ورزشی، دانشکده علوم‌تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل،ایران

3 استادیار گروه فیزیولوژی ورزشی، گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم اجتماعی، دانشگاه بین المللی امام خمینی(ره) ، قزوین، ایران



هدف: دیابت نوع 2 وضعیتی است که منجر به اختلال در حمل و نقل آکسونی می‌شود و ورزش می‌تواند منجر به بهبود آن شود. با این حال، مکانیسم‌ها و تأثیر ورزش در این اختلالات به طور کامل شناخته نشده است. هدف از مطالعه حاضر  تأثیر تمرینات ترکیبی بر کینزین-1 سرمی و عملکرد جسمانی مردان سالمند مبتلا به  دیابت نوع 2  بود. روش شناسی: در این مطالعه نیمه تجربی بالینی 16 مرد سالمند مبتلا به دیابت (سن: 50/1± 07/67 سال) به طور تصادفی در دو گروه کنترل و  گروه تمرینات مقاومتی هوازی به طور مساوی قرار گرفتند. تمرینات به مدت هشت هفته و سه جلسه در هفته به مدت 90 دقیقه انجام شد. متغیر خونی کینزین-1 و شاخص‌های جسمانی 48 ساعت قبل و بعد از تمرین، اندازه‌گیری شدند. از آزمون تی زوجی برای بررسی تغییرات درون‌گروهی و از  آزمون آنکوا برای بررسی تفاوت بین گروه‌ها  استفاده شد. کلیه محاسبات آماری با استفاده از نرم‌افزار SPSS نسخه 23 در سطح معنی­داری 05/0P< انجام شد. یافته­ها : آزمون تی زوجی نشان می‌دهد در گروه تمرین مقادیر کینزین-1 (14/4= t،08/0=P) کاهش، قدرت پائین تنه(26/2= t، 01/0=P) افزایش معنادار و مقادیر استقامت هوازی (15/5= t،07/0=P) و  قدرت بالاتنه (80/1=t، 09/0=P) پس از مداخله افزایش داشتند. آنالیز بین گروهی، افزایش معناداری را در مقادیر استقامت هوازی(006/0= P، 80/11=F) و قدرت پایین تنه (01/0= P، 80/10=F) نشان داد. همچنین سطوح کینزین-1 (07/0= P، 23/61=F) کاهش و قدرت بالا تنه(08/0=P، 70/8=F)  افزایش داشتند ولی معنادار نبودند. نتیجه‌گیری: احتمالا تجویز تمرینات ترکیبی در سالمندان مبتلا به دیابت نوع 2 باعث بهبود  شاخص‌های جسمانی و مقادیرکینزین-1 در سالمندان دیابتی شده است.



عنوان مقاله [English]

Effects of combined exercise on serum kinesin-1 levels and physical performance in elderly men with type 2 diabetes

نویسندگان [English]

  • Seydeh Parisa Hashmi 1
  • Seyed Hamed Ghiyami 2
  • Hassan Pourrazi 3
1 Master&#039;s student, Faculty of Humanities, Alborz University, Abyek, Iran
2 Phd in Sports Physiology, Faculty of Educational Sciences and Psychology, Mohaghegh Ardabili University, Ardabil, Iran
3 Assistant Professor, Department of Physical Education and Sports Science, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran.
چکیده [English]

Aim:      Type 2 diabetes is a condition that leads to impaired axonal transport, and exercise can lead to its improvement. However, the mechanisms and effects of exercise in these disorders still need to be fully understood. This study aimed to examine the effect of combined exercises on serum kinesin-1 and the physical performance of older men with type 2 diabetes. Method:   In this clinical semi-experimental study, 16 older men with diabetes (age: 67.07 ± 1.50 years) were randomly divided into two control groups and aerobic resistance training groups. The exercises were done for eight weeks and three sessions per week for 90 minutes. Kinesin-1 blood variable and performance  physical  were measured 48 hours before and after training. Paired t-test was used to check intra-group changes, and the ANCOVA test was used to check the difference between groups. All statistical calculations were performed using SPSS version 23 software at a significance level of P<0.05.Results: Paired t-test shows that in the training group, kinesin-1 values (t = 4.14, P = 0.08) decreased, lower body strength (t = 2.26, P = 0.01) significantly increased, and aerobic endurance values ( t=5.15, P=0.07) and upper body strength (t=1.80, P=0.09) increased after the intervention. Intergroup analysis showed a significant increase in aerobic endurance values (P=0.006, F=11.80) and lower body strength (P=0.01, F=10.80). Also, the levels of kinesin-1 (P=0.07, F=61.23) decreased, and upper body strength increased (P=0.08, F=8.70), but they were not significant. Conclusion: According to the results of prescribing combined exercises in The elderly with type 2 diabetes, it can have the most excellent effect on improving functional indices and improving kinesin-1 values in diabetic elderly.Conclusion:  Prescribing combined exercises in the elderly with type 2 diabetes has probably improved  physical performance and kinesin-1 levels in the elderly with diabetes

کلیدواژه‌ها [English]

  • Combined exercises
  • kinesin-1
  • physical performance
  • elderly
  • type 2 diabetes
  1. Khalangot M, Tronko M, Kravchenko V, Kulchinska J, Hu G. Body mass index and the risk of total and cardiovascular mortality among patients with type 2 diabetes: a large prospective study in Ukraine. Heart. 2009;95(6):454-60.
  2. Zochodne D, Ramji N, Toth C. Neuronal targeting in diabetes mellitus: a story of sensory neurons and motor neurons. The Neuroscientist. 2008;14(4):311-8.
  3. Ogren SA, Huckins CJ. Culvert replacements: improvement of stream biotic integrity? Restoration Ecology. 2015;23(6):821-8.
  4. Śmieja M, Orzechowski J, Stolarski MS. TIE: An ability test of emotional intelligence. PLoS One. 2014;9(7):e103484.
  5. Nguyen TQ, Chenon M, Vilela F, Velours C, Aumont-Nicaise M, Andreani J, et al. Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. PloS one. 2017;12(10):e0186354.
  6. Allen MD, Major B, Kimpinski K, Doherty TJ, Rice CL. Skeletal muscle morphology and contractile function in relation to muscle denervation in diabetic neuropathy. Journal of Applied Physiology. 2014;116(5):545-52.
  7. Li W, Allen ME, Rui Y, Ku L, Liu G, Bankston AN, et al. p39 is responsible for increasing Cdk5 activity during postnatal neuron differentiation and governs neuronal network formation and epileptic responses. Journal of Neuroscience. 2016;36(44):11283-94.
  8. Hilton TN, Tuttle LJ, Bohnert KL, Mueller MJ, Sinacore DR. Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and function. Physical therapy. 2008;88(11):1336-44.
  9. Allen MD, Doherty TJ, Rice CL, Kimpinski K. Physiology in Medicine: neuromuscular consequences of diabetic neuropathy. Journal of Applied Physiology. 2016;121(1):1-6.
  10. Kluding PM, Pasnoor M, Singh R, Jernigan S, Farmer K, Rucker J, et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. Journal of Diabetes and its Complications. 2012;26(5):424-9.
  11. Cooper MA, Kluding PM, Wright DE. Emerging relationships between exercise, sensory nerves, and neuropathic pain. Frontiers in neuroscience. 2016;10:372.
  12. Fisher M, Langbein W, Collins E, Williams K, Corzine L. Physiological improvement with moderate exercise in type II diabetic neuropathy. Electromyography and clinical neurophysiology. 2007;47(1):23-8.
  13. Tolliver DE, Tisdell EJ. Engaging Spirituality in the Transformative Higher Education Classroom. New directions for adult and continuing education. 2006;109:37-47.
  14. Kluding PM, Pasnoor M, Singh R, D'Silva LJ, Yoo M, Billinger SA, et al. Safety of aerobic exercise in people with diabetic peripheral neuropathy: single-group clinical trial. Physical therapy. 2015;95(2):223-34.
  15. Da Costa D, Dritsa M, Ring A, Fitzcharles MA. Mental health status and leisure‐time physical activity contribute to fatigue intensity in patients with spondylarthropathy. Arthritis Care & Research. 2004;51(6):1004-8.
  16. Verdijk LB, Gleeson BG, Jonkers RA, Meijer K, Savelberg HH, Dendale P, et al. Skeletal muscle hypertrophy following resistance training is accompanied by a fiber type–specific increase in satellite cell content in elderly men. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2009;64(3):332-9.
  17. Delshad M, Ebrahim K, Gholami M, Ghanbarian A. The effect of resistance training on prevention of sarcopenia in women over 50. 2011. [In Persian]
  18. Aguiar AF, Buzzachera CF, Pereira RM, Sanches VC, Januário RB, Da Silva RA, et al. A single set of exhaustive exercise before resistance training improves muscular performance in young men. European journal of applied physiology. 2015;115(7):1589-99.
  19. Falah A, Khayambashi K, Rahnama N, Ghoddousi N. Effects of hip abductor and external rotators strengthening and quadriceps strengthening in females with patellofemoral pain syndrome: A comparative study. Journal of Research in Rehabilitation Sciences. 2012;8(2):354-62. . [In Persian]
  20. Pyka G, Wiswell RA, Marcus R. Age-dependent effect of resistance exercise on growth hormone secretion in people. The Journal of Clinical Endocrinology & Metabolism. 1992;75(2):404-7.
  21. Hasanpour M. Comparison of the effect of two whole-body resistance training models on anaerobic, strength, body composition and functional factors in young and young Taekwondo athletes [MSc Thesis]. Tehran: North Tehran Branch, Islamic Azad University. 2017. [In Persian]
  22. bahram me, Afroundeh R, Pourvaghar MJ. The effect of 12 weeks of training with total body resistance on static and dynamic balance in older men. Iranian Journal of Rehabilitation Research in Nursing. 2020;6(4):30-8. [In Persian]
  23. Umpierre D, Ribeiro P, Schaan B, Ribeiro J. Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis. Diabetologia. 2013;56(2):242-51.
  24. Oliveira C, Simões M, Carvalho J, Ribeiro J. Combined exercise for people with type 2 diabetes mellitus: a systematic review. Diabetes research and clinical practice. 2012;98(2):187-98.
  25. Paahoo A, Tadibi V, Behpoor N. Effect of Two Chronic Exercise Protocols on Pre-Atherosclerotic and Anti-Atherosclerotic Biomarkers Levels in Obese and Overweight Children. Iranian Journal of Pediatrics. 2020;30(2). . [In Persian]
  26. Hogas S, Bilha SC, Branisteanu D, Hogas M, Gaipov A, Kanbay M, et al. Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3. Archives of medical science: AMS. 2017;13(4):897.
  27. Kruse RL, LeMaster JW, Madsen RW. Fall and balance outcomes after an intervention to promote leg strength, balance, and walking in people with diabetic peripheral neuropathy:“feet first” randomized controlled trial. Physical therapy. 2010;90(11):1568-79.
  28. Baptista FI, Pinto MJ, Elvas F, Almeida RD, Ambrosio AF. Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus. PloS one. 2013;8(6):e65515.
  29. Morrison S, Colberg SR, Parson HK, Vinik AI. Exercise improves gait, reaction time and postural stability in older adults with type 2 diabetes and neuropathy. Journal of Diabetes and its Complications. 2014;28(5):715-22.
  30. Touvra A-M, Volaklis KA, Spassis AT, Zois CE, Douda HT, Kotsa K, et al. Combined strength and aerobic training increases transforming growth factor-β1 in patients with type 2 diabetes. Hormones. 2011;10(2):125-30.
  31. Shenoy S, Guglani R, Sandhu JS. Effectiveness of an aerobic walking program using heart rate monitor and pedometer on the parameters of diabetes control in Asian Indians with type 2 diabetes. Primary Care Diabetes. 2010;4(1):41-5.
  32. Seyedizadeh SH, Cheragh-Birjandi S, Hamedi Nia MR. The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials). J Diabetes Res. 2020;2020:6978128. [In Persian]
  33. Ferriolli E, Pessanha FPAS, Marchesi JCLS. Diabetes and exercise in the elderly. Diabetes and physical activity. 2014;60:122-9.
  34. Rikli RE, Jones CJ. Senior fitness test manual: Human kinetics; 2013.
  35. Ahmadizad S, Haghighi AH, Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. European journal of Endocrinology. 2007;157(5):625-32.[In Persian]
  36. Khanbabazade M, Ebrahimi Atri A, Rashid lamir A. Comprision of the effect of aerobic and weight resistance training protocols on balance and neuron growth factor(NGF) on the Neuropathy– Diabetic Men. The Journal of Shahid Sadoughi University of Medical Sciences. 2015;23(2):1866-77. . [In Persian]
  37. Dixit S, Maiya AG, Shastry BA. Effect of aerobic exercise on peripheral nerve functions of population with diabetic peripheral neuropathy in type 2 diabetes: A single blind, parallel group randomized controlled trial. Journal of Diabetes and its Complications. 2014;28(3):332-9.
  38. LEITZELAR, Brianna N.; KOLTYN, Kelli F. Exercise and neuropathic pain: a general overview of preclinical and clinical research. Sports medicine-open, 2021, 7.1: 1-16.‏
  39. Jahani Golbar S, Gharekhanlu R, Kordi MR, Khazani A. Effects of Endurance Exercise Training on Kinesin - 5 and Dynein Motor Proteins in Sciatic Nerves of Male Wistar Rats with Diabetic Neuropathy. Int J Sport Stud Hlth. 2018;1(1):e67758. . [In Persian]
  40. Derakhshan Nejad M, Nikbakht M, Ghanbarzadeh M, Ranjbar R. Effect of Concurrent Training Order With Electromyostimulation on Physical Performance in Young Elderly Women. Archives of Rehabilitation. 2020;21(4):508-25.
  41. Tessier D, Ménard J, Fülöp T, Ardilouze J-L, Roy M-A, Dubuc N, et al. Effects of aerobic physical exercise in the elderly with type 2 diabetes mellitus. Archives of gerontology and geriatrics. 2000;31(2):121-32.
  42. Lambers S, Van Laethem C, Van Acker K, Calders P. Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clinical Rehabilitation. 2008;22(6):483-92.
  43. Dagna L, Salvo F, Tiraboschi M, Bozzolo EP, Franchini S, Doglioni C, et al. Pentraxin-3 as a marker of disease activity in Takayasu arteritis. Annals of internal medicine. 2011;155(7):425-33.
  44. Esposito K, Pontillo A, Ciotola M, Di Palo C, Grella E, Nicoletti G, et al. Weight loss reduces interleukin-18 levels in obese women. The journal of clinical endocrinology & metabolism. 2002;87(8):3864-6.
  45. Savchenko A, Imamura M, Ohashi R, Jiang S, Kawasaki T, Hasegawa G, et al. Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions. The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland. 2008;215(1):48-55.