مقایسه اثر 8 هفته تمرینات متفاوت (استقامتی، مقاومتی و ترکیبی) بر روی سطوح سرمی نسفاتین-1 و شاخص مقاومت به انسولین در زنان مبتلا به دیابت نوع 2

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 کارشناس ارشد فیزیولوژی فعالیت بدنی و تندرستی، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه صنعتی شاهرود، سمنان، ایران.

2 دانشیار فیزیولوژی ورزش، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه صنعتی شاهرود، سمنان، ایران.

3 استادیار فیزیولوژی ورزش، گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه صنعتی شاهرود، سمنان، ایران.

10.22049/jahssp.2023.27986.1495

چکیده

هدف: نسفاتین-1آدیپوکاینی است که از بافت چربی ترشح شده و در سازوکار تنظیم عملکرد انسولین و متابولیسم گلوکز شرکت دارد. بنابراین، هدف پژوهش حاضر مقایسه اثر 8 هفته تمرینات متفاوت (استقامتی، مقاومتی و ترکیبی) بر روی سطوح سرمی نسفاتین-1 و شاخص مقاومت به انسولین در زنان مبتلا به دیابت نوع 2 بود. روش شناسی: این تحقیق نیمه تجربی، شامل پیش آزمون و پس آزمون با 3 گروه تجربی و یک گروه کنترل می­باشد. نمونه آماری این پژوهش را زنان مبتلا به دیابت نوع 2، با میانگین سنی (7/6 82/50 سال) و شاخص توده بدنی (Kg/m2 35/4 82/29) تشکیل دادند که به­صورت تصادفی به 4 گروه 15 نفری: 1- تمرین هوازی 2- تمرین مقاومتی 3- تمرین ترکیبی و 4- گروه کنترل تقسیم شدند. نمونه­های خونی قبل از شروع تمرینات و 48 ساعت پس از اتمام تمرینات در وضعیت ناشتا جمع آوری شد. از آزمون T وابسته برای ارزیابی تفاوت درون گروهی، آزمون ANOVA برای ارزیابی تفاوت بین گروهی، سطح معناداری 05/0 > p استفاده شد. یافته‌ها: یافته­ها نشان داد، سطوح سرمی نسفاتین-1 در گروه­های تمرین مقاومتی (02/0p=) و تمرین ترکیبی (009/0p=) بعد از مداخله افزایش معناداری یافته است، سطح سرمی گلوکز ناشتا در گروه­های هوازی (04/0p=) و ترکیبی (04/0p=)، سطح سرمی انسولین در گروه ترکیبی (007/0p=)، شاخص مقاومت به انسولین در گروه ترکیبی (006/0p=)، سطح سرمیTG  در گروه­های هوازی (007/0p=) و ترکیبی (006/0p=)، سطح سرمی LDL در گروه­های مقاومتی (018/0p=) و ترکیبی (001/0p=)، سطح سرمی کلسترول در گروه­های هوازی (03/0p=)، مقاومتی (04/0p=) و ترکیبی (02/0p=)، شاخص BMI در گروه­ ترکیبی (001/0p=)، درصد چربی بدن نیز در گروه ترکیبی (04/0p=)  کاهش معنی­داری یافته بود. همچنین سطوح سرمی HDL در گروه­های هوازی (006/0p=) و ترکیبی (005/0p=) و شاخص عملکرد سلول­های بتا در گروه ترکیبی (001/0p=)، افزایش معناداری یافته بود. نتیجه‌گیری: با توجه به نتایج این مطالعه به ­نظر می­رسد، تمرینات ترکیبی محرک مناسب­تری برای افزایش سطوح سرمی نسفاتین-1 پلاسما و کاهش عوامل خطر در زنان مبتلا به دیابت نوع 2 می­باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Comparison of the effect of 8 weeks of different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes

نویسندگان [English]

  • Roghayeh Koroni 1
  • Ali Yonesyan 2
  • Adel Donyaei 3
1 MSc of physiology of physical activity and Health, Department of Sports Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran.
2 Associate Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran.
3 Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahrood University of Technology, Semnan, Iran.
چکیده [English]

Aim:  Nesfatin-1 is an adipokine that is secreted from adipose tissue and is involved in the regulation of insulin action and glucose metabolism. The aim of this study was  Comparison the effect of 8 weeks different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes. Methods: This quasi-experimental study included a pre-test and post-test with 3 experimental groups and one control group. The statistical sample of this research was included of women with type 2 diabetes, with an average age (50.82+6.7 years) and body mass index (29.82+4.35 Kg/m2), That were divided into four groups of 15 people: 1- aerobic training, 2- resistance training, 3- combined training and 4- control group. Blood samples were collected before the beginning of the exercises and 48 hours after the end of the exercises in the fasting state. Dependent T test was used to evaluate intra-group difference, ANOVA test was used to evaluate inter-group difference, significance level p < 0.05. Results: The findings showed that the serum levels of nesfatin-1 in the resistance training groups (p=0.02) and combined training (p=0.009) increased significantly after the intervention, the fasting glucose serum level in the aerobic groups ( (p=0.04) and combined (p=0.04), insulin serum level in the combined group (p=0.007), insulin resistance index in the combined group (p=0.006), serum TG level in aerobic groups (p=0.007) (p=0.006) and combined (p=0.006), LDL serum level in resistance groups (p=0.018) and combined (p=0.001), cholesterol serum level in aerobic groups (p=0.03), resistance (p=0.04) and combined (p=0.02), BMI index in the combined group (p=0.001), body fat percentage also decreased significantly in the combined group (p=0.04). Also, HDL serum levels in the aerobic (p=0.006) and combined (p=0.005) groups and beta cell performance index in the combined group (p=0.001) increased significantly. Conclusions: According to the results of this study, it seems that combined exercises are a more suitable stimulus for increasing nesfatin-1 serum levels and reducing risk factors in women with type 2 diabetes.

کلیدواژه‌ها [English]

  • Endurance exercises
  • resistance
  • combined
  • Nesfatin-1
  • insulin resistance

Publisher: Azarbaijan Shahid Madani University          Copyright © The Authors   

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 10، شماره 1
فروردین 1402
صفحه 83-96

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  • تاریخ دریافت: 23 شهریور 1401
  • تاریخ بازنگری: 14 دی 1401
  • تاریخ پذیرش: 22 دی 1401

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