تأثیر هشت هفته تمرین پیلاتس و مکمل‌دهی دانه کرفس بر سطوح سرمی CRP و ESR در زنان میانسال مبتلا به آرتریت‌روماتوئید

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 کارشناس ارشد، گروه فیزیولوژی ورزشی، دانشکدة ادبیات و علوم انسانی، دانشگاه قم، قم، ایران

2 استادیار فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکدة ادبیات و علوم انسانی، دانشگاه قم، قم، ایران

3 کارشناس ارشد، گروه فیزیولوژی ورزشی، دانشکدة ادبیات و علوم انسانی، دانشگاه شاهد، تهران، ایران

10.22049/jassp.2020.26847.1313

چکیده

هدف: هدف پژوهش حاضر، مطالعه­ اثر هشت هفته تمرین پیلاتس و مکمل ­دهی پودر دانه کرفس بر سطوح سرمی CRP و ESR زنان میانسال مبتلا به آرتریت­ روماتوئید بود. روش‌شناسی: تعداد 40 نفر از زنان مبتلا به آرتریت ­روماتوئید مراجعه کننده به بیمارستان شریعتی تهران با میانگین سنی­ 5/35±53/10 و میانگین وزنی 5/93±62/37 به طور تصادفی به چهار گروه کنترل (10­=n)­، تمرین و دارونما (10­=n)­­، مکمل (10­=n)­ و مکمل و تمرین (10­=n)­ تقسیم شدند. آزمودنی­های گروه تمرین به مدت هشت هفته، سه جلسه در هفته با شدت 65 درصد از حداکثر ضربان قلب به مدت 60 دقیقه به انجام تمرین­های پیلاتس پرداختند. بیماران گروه مکمل به مدت 8 هفته، روزانه به میزان 1/3 گرم دانه کرفس پودر شده در سه وعده مصرف کردند. یافته‌ها با وجود کاهش CRP سرم گروه تمرین+مکمل­ (p <0/05)، تغییر معنی­ داری در ESR منجر نشد (p≥0/05). نتیجه‌ گیری: مصرف توام مکمل پودر دانه کرفس تمرین ­های ورزشی پیلاتس تا حدی در کنترل التهاب بیماران مبتلا به آرتریت­ روماتوئید مؤثر است، اما به دلیل کمبود شواهد و محدودیت‌های تحقیق، هنوز نیاز به بررسی‌های بیشتر باقی است.

کلیدواژه‌ها


عنوان مقاله [English]

The Effects of 8 weeks of Pilates Training and Celery Seeds Powder Supplementation on Serum CRP Level and ESR in Middle Aged Women with Rheumatoid Arthritis

نویسندگان [English]

  • Seyedeh Sahar Reyhani 1
  • Ali Ghasemi Kahrizsangi 2
  • Touba Ahmadi Rostamkolaei 3
1 Msc of Exercise Physiology, Department of Sport Sciences, Faculty of Humanities, University of Qom, Qom, Iran
2 Assistant Professor, Department of Sport Sciences, Faculty of Humanities, University of Qom, Qom, Iran.
3 Msc of Exercise Physiology, Department of Sport Sciences, Faculty of Humanities, Shahed University , Tehran, Iran
چکیده [English]

Aim: The aim was to investigate the effect of eight weeks of Pilates training and Celery seeds supplementation on serum CRP and ESR level in middle-aged women with rheumatoid arthritis. Methods: 40 women with rheumatoid arthritis referred to Shariati Hospital in Tehran (age: 53.10±5.35 years, weight: 62.37±5.93 kg) were randomly divided into Control (n=10), Training and Placebo (n=10), Supplement (n =10) and Supplement + Training (n =10) groups. The training subjects experienced eight weeks of Pilates exercises, three sessions/week at 65% of MHR up to 60 min. the supplementation groups consumed 1.3 g Celery seeds powder three times daily for eight weeks. Results: in spite of serum CRP down regulation in Supplement + Training group (p < 0/05), no significant change were recorded for ESR in this group (p≥0/05). Conclusions: synchronized Pilates training in accompany with Celery seeds supplementation could be beneficial in controlling inflammatory status of patients with rheumatoid arthritis. However, more investigations remain to be done because of the lack of similar evidence and also limitations in this study.

کلیدواژه‌ها [English]

  • Rheumatoid Arthritis
  • Pilates
  • Celery
  • CRP
  • ESR
Lee DM, Weinblatt ME. Rheumatoid arthritis Lancet 358.
2. Yousefi B, Jadidi-Niaragh F, Azizi G, Hajighasemi F, Mirshafiey A. The role of leukotrienes in immunopathogenesis of rheumatoid arthritis. Modern rheumatology. 2014 Mar 1;24(2):225-35.
3. Nalbandian G, Kovats S. Understanding sex biases in immunity. Immunologic research. 2005 Mar 1;31(2):91-106.
4. Stanich JA, Carter JD, Whittum-Hudson J, Hudson AP. Rheumatoid arthritis: Disease or syndrome?. Open access rheumatology: research and reviews. 2009;1:179.
5. Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara KI, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes & development. 2003 Oct 1;17(19):2436-49.
6. Laine L, Curtis SP, Cryer B, Kaur A, Cannon CP. Risk factors for NSAID‐associated upper GI clinical events in a long‐term prospective study of 34 701 arthritis patients. Alimentary pharmacology & therapeutics. 2010 Nov;32(10):1240-8.
7. Silva I, Mateus M, Branco JC. Assessment of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) on rheumatoid arthritis activity prediction. Acta reumatologica portuguesa. 2010;35(5):456-62.
8. Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C, Katz LM, Lightfoot Jr R, Paulus H, Strand V, Tugwell P. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 1995 Jun;38(6):727-35.
9. Plant MJ, Jones PW, Saklatvala J, Ollier WE, Dawes PT. Patterns of radiological progression in early rheumatoid arthritis: results of an 8 year prospective study. The Journal of rheumatology. 1998 Mar;25(3):417-26.
10. Dupuy AM, Terrier N, Senecal L, Morena M, Leray H, Canaud B, Cristol JP. Is C-reactive protein a marker of inflammation? Nephrologie. 2003;24(7):337-41.
11. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. New England journal of medicine. 2002 Nov 14;347(20):1557-65.
12. SOX HC, Liang MH. Diagnostic decision: the erythrocyte sedimentation rate: guidelines for rational use. Annals of internal medicine. 1986 Apr 1;104(4):515-23.
13. Plebani M, Piva E. Erythrocyte sedimentation rate: use of fresh blood for quality control. American journal of clinical pathology. 2002 Apr 1;117(4):621-6.
14. Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, Yale SH. Erythrocyte sedimentation rate and C-reactive protein measurements and their relevance in clinical medicine. Wmj. 2016 Dec;115(6):317-21.
15. Schulak DJ, Rayhack JM, Lippert 3rd FG, Convery FR. The erythrocyte sedimentation rate in orthopaedic patients. Clinical orthopaedics and related research. 1982 Jul 1(167):197-202.
16. da Costa Moura C. Development of Multifunctional Nanoparticles for Targeted Therapy and Imaging of Rheumatoid Arthritis.
8  ریحانی و همکاران، مطالعات کاربردی تندرستی در فیزیولوژی ورزش، پاییز و زمستان 1399 ، جلد هفتم، شماره دوم
17. Nasri S, Shahi SadrAbadi F, Kamalinejhad M, Rabbani T. Investigation of the possible mechanism of antinociceptive effect of Apium graveolens hydroalcoholic fruits extract. Journal of Arak University of Medical Sciences. 2012 Oct 10;15(5):66-75.
18. Mencherini T, Cau A, Bianco G, Loggia RD, Aquino RP, Autore G. An extract of Apium graveolens var. dulce leaves: Structure of the major constituent, apiin, and its anti‐inflammatory properties. Journal of pharmacy and pharmacology. 2007 Jun;59(6):891-7.
19. Moghadam, M. H., Imenshahidi, M., & Mohajeri, S. A. (2013). Antihypertensive effect of celery seed on rat blood pressure in chronic administration. Journal of medicinal food, 16(6), 558-563.
20. Sultana S, Ahmed S, Jahangir T, Sharma S. Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development. Cancer letters. 2005 Apr 18;221(1):11-20.
21. Minor MA, Hewett JE, Webel RR, Dreisinger TE, Kay DR. Exercise tolerance and disease related measures in patients with rheumatoid arthritis and osteoarthritis. The Journal of rheumatology. 1988 Jun;15(6):905-11.
22. Hicks JE. Rehabilitation strategies for patients with rheumatoid arthritis. The Journal of Musculoskeletal Medicine. 2000 Apr 1;17(4):191-.
23. Khalili M, Golpayegani M, Shahrjerdi S. The effect of eight weeks Pilates training on pain and quality of life in men with Rheumatoid arthritis [in persian].
24. She J, Nakamura H, Makino K, Ohyama Y, Hashimoto H. Selection of suitable maximum-heart-rate formulas for use with Karvonen formula to calculate exercise intensity. International Journal of Automation and Computing. 2015 Feb 1;12(1):62-9.
25. Madadi Jaberi, Mitra and Omid Mohammaddoost. Investigating the Interactive Effect of Endurance Training and Consumption of Celery Seed Supplement on CRP and Lipid Profile in Obese Women, Second National Conference on New Achievements in Physical Education and Sports, Chabahar, Chabahar International University [in persian].
26. Rafieian M, Shahrani M, Pilehvarian A, Khayri S, Rabii R, Momeni A. Effectof APium graveolensOn
blood liPids in Patients taking lovastatin :A clinical study. J Shahrekord Univ Med Sci.2009 ; 10 (4) 10 (4) :70-76. [In Persian]
27. Drugs.com [Internet]. Natural Products (Pro) Celery Information from Drugs.com; Copyright © 2020 Wolters Kluwer Health [Updated: 14 February 2020, Cited: 27 July 2020]. Available from: https://www.drugs.com/npp/celery.html .
28. Hussain IMT, Ahmed G, Jahan N, et al. Unani description of Tukhme Karafs (seeds of Apium graveolens). International Research Journal of Biological Sciences, 2013;2(11):88-93.
29. Mendall MA, Patel P, Ballam L, Strachan D, Northfield TC. C reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. Bmj. 1996 Apr 27;312(7038):1061-5.
30. Tracy RP, Lemaitre RN, Psaty BM, Ives DG, Evans RW, Cushman M, Meilahn EN, Kuller LH. Relationship of C-reactive protein to risk of cardiovascular disease in the elderly: results from the Cardiovascular Health Study and the Rural Health Promotion Project. Arteriosclerosis, thrombosis, and vascular biology. 1997 Jun;17(6):1121-7.
31. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. New England journal of medicine. 1997 Apr 3;336(14):973-9.
32. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. The Journal of clinical investigation. 1995 May 1;95(5):2409-15.
33. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. The Journal of clinical investigation. 1995 May 1;95(5):2111-9.
34. Warren RS, Starnes HF, Gabrilove JL, Oettgen HF, Brennan MF. The acute metabolic effects of tumor necrosis factor administration in humans. Archives of Surgery. 1987 Dec 1;122(12):1396-400.
35. Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. Journal of the American College of Cardiology. 2005 May 17;45(10):1563-9.
9 در زنان میانسال مبتلا به آرتریتروماتوئید ESR و CRP تأثیر هشت هفته تمرین پیلاتس و مکملدهی دانه کرفس بر سطوح سرمی
36. Church TS, Barlow CE, Earnest CP, Kampert JB, Priest EL, Blair SN. Associations between cardiorespiratory fitness and C-reactive protein in men. Arteriosclerosis, thrombosis, and vascular biology. 2002 Nov 1;22(11):1869-76.
37. Steinvil A, Shapira I, Arbel Y, Justo D, Berliner S, Rogowski O. Determinants of the erythrocyte sedimentation rate in the era of microinflammation: excluding subjects with elevated C-reactive protein levels. American journal of clinical pathology. 2008 Mar 1;129(3):486-91.
38. Piva E, Sanzari MC, Servidio G, Plebani M. Length of sedimentation reaction in undiluted blood (erythrocyte sedimentation rate): variations with sex and age and reference limits. Clinical chemistry and laboratory medicine. 2001 Jun 6;39(5):451-4.
39. Goldhammer E, Tanchilevitch A, Maor I, Beniamini Y, Rosenschein U, Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. International journal of cardiology. 2005 Apr 8;100(1):93-9.
40. Okita K, Nishijima H, Murakami T, Nagai T, Morita N, Yonezawa K, Iizuka K, Kawaguchi H, Kitabatake A. Can exercise training with weight loss lower serum C-reactive protein levels?. Arteriosclerosis, thrombosis, and vascular biology. 2004 Oct 1;24(10):1868-73.
41. Dabidy Roshan."The effect of two methods of continuous and periodic aerobic training and a period of non-training on Inflammatory Conclusions Predicting Cardiovascular Failure in Rats ", PhD Thesis Specialized in Exercise Physiology, University of Tehran. (2005). [In Persian]
42. Pestana MD, Netto EM, Pestana MC, Pestana VS, Schinoni MI. Pilates versus resistance exercise on the serum levels of hs-CRP, in the abdominal circumference and body mass index (BMI) in elderly individuals. Motricidade. 2016 Jun 24;12(1):128-40.
43. Czarkowska-Paczek B, Bartlomiejczyk I, Gabrys T, Przybylski J, Nowak M, Paczek L. Lack of relationship between interleukin-6 and CRP levels in healthy male athletes. Immunology letters. 2005 Jun 15;99(1):136-40.
44. Fischer CP, Berntsen A, Perstrup LB, Eskildsen P, Pedersen BK. Plasma levels of interleukin‐6 and C‐reactive protein are associated with physical
inactivity independent of obesity. Scandinavian journal of medicine & science in sports. 2007 Oct;17(5):580-7.
45. Hammett CJ, Oxenham HC, Baldi JC, Doughty RN, Ameratunga R, French JK, White HD, Stewart RA. Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects. Journal of the American College of Cardiology. 2004 Dec 21;44(12):2411-3.
46. Marcell TJ, McAuley KA, Traustadóttir T, Reaven PD. Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism. 2005 Apr 1;54(4):533-41.
47. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, Chrousos GP, Sidossis LS. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism. 2005 Nov 1;54(11):1472-9.
48. Pan MH, Lai CS, Ho CT. Anti-inflammatory activity of natural dietary flavonoids. Food & function. 2010;1(1):15-31.