تأثیر 8 هفته تمرین تناوبی با شدت بالا (HIIT) بر مقادیر سرمی آیریزین، FGF21 و شاخص‌های گلایسمی در زنان دیابتی نوع 2

نوع مقاله: مقاله پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

2 دانشیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

3 استادیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

چکیده

در اثر فعالیت ورزشی، مایوکاین‌هایی نظیر آیریزین و FGF21 با میانجی‌گری اثرات ضد التهابی خود، در مهار پیشرفت مقاومت به انسولین ناشی از دیابت نوع 2 موثر می‌باشند. از این ‌رو، هدف پژوهش حاضر بررسی تأثیر 8 هفته HIIT بر مقادیر سرمی آیریزین، FGF21و شاخص‌های گلایسمی در زنان دیابتی نوع 2 می‌باشد.
20 زن مبتلاء به دیابت نوع 2 (سن: 3/55 و BMI: 09/27) به ‌طور تصادفی در دو گروه 10 نفری HIIT و کنترل تقسیم‌بندی شدند. برنامه تمرین HIIT به مدت 8 هفته، 3 جلسه در هفته و با شدت 85 ـ 80 درصد ضربان قلب بیشینه اجرا شد. پیش و پس از اتمام برنامه تمرینی از دو گروه در حالت ناشتا نمونه‌گیری خونی به عمل آمد تا مقادیر سرمی آیریزین، FGF21و شاخص‌های‌ گلایسمی اندازه‌گیری شود. داده‌های پژوهش با استفاده از آزمون آماری t همبسته و tمستقل تجزیه‌ و تحلیل شدند(05/0 >p).
HIIT به‌ طور معناداری مقادیر سرمی آیریزین و FGF21 زنان دیابتی نوع 2 را بعد از 8 هفته افزایش (001/0p=) و HBA1c (003/0p=)، گلوکز و مقاومت به انسولین (006/0p=) را کاهش داد. بین گروه تمرین و کنترل در مقادیر FGF21، آیریزین و شاخص‌های گلایسمی تفاوت معنادار وجود داشت (001/0p=).
بر اساس نتایج پژوهش حاضر، به نظر می‌رسد HIITاز طریق تحریک ترشح مایوکاین‌هایی نظیر آیریزین و FGF21در کنترل هومئوستاز قند و مقاومت به انسولین بدن موثر باشد. با وجود این، با توجه به تاثیر آیریزین بر تغییرات بافت چربی سفید و قهوه‌ای، بررسی تغییرات آدیپوکاین‌ها در کنار FGF21 و آیریزین عضلانی با تمرینات HIIT قابل توجه می‌باشد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The effect of 8 weeks of high intensity interval training (HIIT) on Serum Irisin, FGF21 and glycemic indices in type 2 diabetic women

نویسندگان [English]

  • Leyla Alizadeh 1
  • Asghar Tofighi 2
  • Javad Tolouei Azar 3
1 M.Sc. of exercise physiology, Urmia University, Urmia, Iran.
2 Associate professor of exercise physiology, Urmia University, Urmia, Iran.
3 Assistant professor of exercise physiology, Urmia University, Urmia, Iran.
چکیده [English]

Due to physical activities, Myokines such as Irisin and FGF21 by mediating your anti-inflammatory effects are Effective in harnessing the progression of insulin resistance caused by type 2 diabetes. Therefore, the purpose of this study was to investigate the effect of 8 weeks of HIIT on Serum Irisin, FGF21 and Glycemic Indices in Type 2 diabetic women.
20 women with type 2 diabetes (age:55.3 and BMI:27.09) were randomly divided into two groups of HIIT and controls (n=10). The HIIT training program was performed at 8 weeks, 3 sessions per week and with an intensity of 85-80% of maximum heart rate. Before and after the completion of the exercise program, blood samples were taken from two groups in fasting state that measured Serum Irisin, FGF21 and glycemic index. Data were analyzed using dependent t-test and independent t-test (p<0.05).
HIIT significantly increased the serum levels of irisin and FGF21 (p=0.001) and decreased HBA1c (p=0.003), glucose and insulin resistance (p= 0.006) in type 2 diabetic women after 8 weeks and. There was a significant difference between exercise and control group in FGF21 and Irisin and glycemic indices (p=0.001).
Based on the results of this study, it seems that HIIT by stimulating the secretion of myokine, such as irisin and FGF21 It's effective in controlling glucose homeostasis and insulin resistance. However, with regard to the effect of irisin on changes in white and brown adipose tissue, Consideration should be given to changes in adipokin with FGF21 and muscle irisin with HIIT exercises.

کلیدواژه‌ها [English]

  • High Intensity Interval Training؛ Irisin؛ FGF21؛ Glycemic index؛ Type 2 Diabetes
  • Woman

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