تأثیر 8 هفته تمرین تناوبی با شدت بالا (HIIT) بر مقادیر سرمی آیریزین، FGF21 و شاخص‌های گلایسمی در زنان دیابتی نوع 2

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

2 دانشیار فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران

3 استادیار فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.

چکیده

هدف: در اثر فعالیت ورزشی، مایوکاین­هایی نظیر آیریزین و FGF21 با میانجی­گری اثرات ضد التهابی خود، در مهار پیشرفت مقاومت به انسولین ناشی از دیابت نوع 2 موثر می­باشند. از این ‌رو، هدف پژوهش حاضر بررسی تأثیر 8 هفته HIIT بر مقادیر سرمی آیریزین،  FGF21و شاخص‌های گلایسمی در زنان دیابتی نوع 2 بود. روش شناسی: 20  زن مبتلاء به دیابت نوع 2 (سن: 3/55 سال و BMI: 09/27 کیلوگرم بر متر مربع) به ‌طور تصادفی در دو گروه 10 نفری  HIIT و کنترل تقسیم‌بندی شدند. برنامه تمرین HIIT به مدت 8 هفته، 3 جلسه در هفته و با شدت 85 ـ 80 درصد ضربان قلب بیشینه اجرا شد. پیش و پس از اتمام برنامه تمرینی از دو گروه در حالت ناشتا نمونه‌گیری خونی به عمل آمد تا مقادیر سرمی آیریزین،  FGF21و شاخص­های‌ گلایسمی اندازه‌گیری شود. داده‌های پژوهش با استفاده از آزمون آماری  t همبسته و  tمستقل تجزیه‌ و تحلیل شدند (05/0 >p). یافته ها:  HIIT به‌ طور معناداری مقادیر سرمی آیریزین و FGF21 زنان دیابتی نوع 2 را بعد از 8 هفته افزایش (001/0p=) و HBA1c (003/0p=)، گلوکز و مقاومت به انسولین (006/0p=) را کاهش داد. بین گروه تمرین و کنترل در مقادیر FGF21، آیریزین و شاخص‌های گلایسمی تفاوت معناداری وجود داشت (001/0p=). نتیجه گیری: بر اساس نتایج پژوهش حاضر، به نظر می‌رسد  HIITاز طریق تحریک ترشح مایوکاین­هایی نظیر آیریزین و  FGF21در کنترل هومئوستاز قند و مقاومت به انسولین بدن موثر باشد. با وجود این، با توجه به تاثیر آیریزین بر تغییرات بافت چربی سفید و قهوه­ای، بررسی تغییرات آدیپوکاین­ها در کنار FGF21 و آیریزین عضلانی با تمرینات HIIT قابل توجه می­باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of 8 Weeks of High Intensity Interval Training (HIIT) On Serum Irisin, FGF21 and Glycemic Indices in Type 2 Diabetic Women

نویسندگان [English]

  • Leyla Alizadeh 1
  • Asghar Tofighi 2
  • Javad Tolouei Azar 3
1 MSc. of Exercise Physiology, Department of Sports Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran.
2 Associate Professor, Department of Sports Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran
3 Assistant Professor, Department of Sports Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran.
چکیده [English]

Aim: Due to exercise, Myokines such as Irisin and FGF21 by mediating anti-inflammatory effects, can Effective in progression of insulin resistance caused by type 2 diabetes. thus, the purpose of this study was to investigate the effect of 8 weeks of HIIT on Serum Irisin, FGF21 and Glycemic Indices in Type 2 diabetic women. Methods: 20 diabetic women (age:55.3 and BMI:27.09) were randomly divided into two groups of HIIT and controls (n=10). The HIIT program performed at 3 sessions per week with 85-80% intensity of maximum heart rate for 8 weeks. Blood samples for measured Serum Irisin, FGF21 and glycemic index were taken from two groups in fasting state. Data were analyzed by dependent t-test and independent t-test (p < 0.05). Results: HIIT significantly increased the serum levels of irisin and FGF21 (p=0.001) and decreased HBA1c (p=0.003), glucose and insulin resistance (p= 0.006) in diabetic women after 8 weeks. There was a significant difference between exercise and control group in FGF21 and Irisin and glycemic indices (p=0.001). Conclusion: Based on the results of this study, it seems that HIIT by stimulating the secretion of myokine, such as irisin and FGF21 can effective in controlling glucose homeostasis and insulin resistance. However, with regard the effect of irisin on changes in white and brown adipose tissue, the study of changes in Adipokine with FGF21 and muscle irisin in HIIT is remarkable.

کلیدواژه‌ها [English]

  • High Intensity Interval Training
  • Irisin
  • FGF21
  • Glycemic Index
  • Type 2 Diabetes
  • Woman

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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 6، شماره 2
مهر 1398
صفحه 17-24

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  • تاریخ دریافت: 19 اردیبهشت 1398
  • تاریخ بازنگری: 31 خرداد 1398
  • تاریخ پذیرش: 30 مرداد 1398

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