تاثیر هشت هفته تمرین یوگا بر سطوح سرمی BDNF زنان مبتلا به مولتیپل اسکلروزیس

نوع مقاله: مقاله پژوهشی

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزش، دانشکدهی علوم انسانی، دانشگاه سمنان، ایران

2 استادیار گروه فیزیولوژی ورزش، دانشکدهی علوم انسانی، دانشگاه سمنان، ایران

چکیده

مولتیپل اسکلروزیس (MS) بیماری التهابی است که باعث آسیب غلاف میلین سلول‌های عصبی در مغز و نخاع می گردد. عامل نورون زایی مشتق از مغز (BDNF) نقش حیاتی در بقای نورون‌ها، آکسون و میلین سازی مجدد دارد. هدف از پژوهش حاضر بررسی تأثیر هشت هفته تمرین یوگا بر سطوح سرمی BDNF در زنان مبتلا به مولتیپل اسکلروزیس بود. شانزده زن مبتلا به MS (با میانگین سن 7/7±8/37 سال، قد 4/7±7/161 سانتی‌متر و وزن 2/18±7/70 کیلوگرم) با نمره مقیاس ناتوانی جسمانی کروتزگه (EDSS) کمتر از 4 انتخاب و به‌طور تصادفی به دو گروه تمرین یوگا (8 نفر) و کنترل (8 نفر) تقسیم شدند. گروه یوگا به مدت هشت هفته و سه جلسه در هفته به تمرین یوگا پرداختند. گروه کنترل صرفا فعالیت روزمره خود را انجام دادند. نمونه‌های خونی 48 ساعت قبل و بعد از دوره تمرین جمع‌آوری گردید. سطوح سرمی BDNF به روش الایزا ارزیابی شد. تجزیه ‌و تحلیل آماری از طریق آزمون t وابسته و مستقل در سطح معناداری  05/0P انجام گرفت. نتایج این پژوهش نشان داد که تمرین یوگا سطوح سرمی BDNF را در زنان مبتلا به MS افزایش می دهد، در حالی که سطوح سرم BDNF در گروه کنترل کاهش یافته بود. در کل نتایج نشان داد، مقدار BDNF سرمی بیماران MS در پاسخ به تمرین یوگا افزایش می یابد که انتظار می رود در فرآیند ترمیم و حفظ اعصاب مفید باشد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The effects of eight weeks yoga training on serum levels of BDNF in women with multiple sclerosis

نویسندگان [English]

  • ُSamaneh Sadi Zadeh 1
  • Seyed Mohsen Avandi 2
  • Mohsen Ebrahimi 2
1 M.Sc of Exercise physiology, Sport Science Department, Human Faculty, Semnan University, Semnan, Iran
2 Assistant Professor of Exercise physiology, Sport Science Department, Human Faculty, Semnan
چکیده [English]

Multiple sclerosis (MS) is demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. Brain-derived neurotrophic factor plays a key role in neuronal and axonal survival and remyelination. The purpose of this study was to investigate the effects of 8 weeks of yoga training on serum BDNF level in female MS patients. Sixteen female with MS (age:37.8± 7.7 years, height: 161.7 ± 7.4 cm, weigh: 70.7 ± 18.2 kg and EDSS <4) were were randomly assigned into yoga (n=8) and control (n=8) groups. The experimental group participated in eight weeks of yoga training (24 sessions, 3 sessions/wk). The control group continued to their daily ordinary activities. Blood samples were collected 48 hours before and after the training period. Serum levels of BDNF were measured with Human BDNF Immunoassay ELISA kits. Statistical analysis of data was performed by paired and independent sample t test at significance level p≤0.05. Results showed that yoga training after 8 weeks could increase serum BDNF level in female MS patients, whereas a synchronized decrease was observed in the control group. Overall the results showed MS patients’ serum BDNF level could be elevated by yoga training which is expected to be beneficial in neuronal repair and maintenance.  

کلیدواژه‌ها [English]

  • Multiple Sclerosis
  • Brain derived Neurotrophic Factor
  • Yoga
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