نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
1 گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد واحد بجنورد، بجنورد، ایران
2 دانشگاه ازاد اسلامی واحد بجنورد
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background& purpose: The PKA/p38 MAPK-HSF1-UCP1 pathway is a key signaling cascade that, in response to cold or adrenergic stimulation, leads to increased UCP1 expression and heat production in brown adipose tissue through sequential phosphorylations. The aim of the present study was to investigate the effect of endurance training on the PKA/p38 MAPK-HSF1-UCP1 pathway in obese male Wistar rats.. Methods: Thirty healthy male Wistar rats with an average age of eight weeks and an average weight of 187.5 ± 9.37 grams were randomly selected and to induce obesity, the rats were placed on a high-fat diet for 8 weeks. The rats were divided into three groups: healthy control, obese control, and endurance training. After confirming obesity, endurance training was applied to the training group for 8 weeks and 5 sessions per week. Real Time-PCR was used to measure the expression of PKA, p38 MAPK, HSF1, and UCP1 genes. One-way analysis of variance and Tukey's post hoc test were used to determine the difference between groups at a significance level of p<0.05.Results: : The expression of PKA, HSF1 and UCP1 genes in the endurance training group was significantly increased compared to the obese control group. The expression of these genes in the obese control group was also significantly decreased compared to the healthy control group. The expression of p38 MAPK gene was also significantly decreased in the endurance training group compared to the obese control group. The expression of this gene in the obese control group was significantly increased compared to the healthy control group . Conclusions: Endurance training by improving the PKA/p38 MAPK-HSF1-UCP1 signaling pathway may be considered an effective strategy for reducing disorders related to overweight and obesity.
کلیدواژهها [English]
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