نقش فعالیت ورزشی بر فاکتورهای نوروتروفیکی مرتبط با بیماری آلزایمر: مطالعه مروری نظام‌مند با فراتحلیل

مقالات آماده انتشار

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 استادیار دانشگاه گلستان

2 گروه علوم ورزشی، دانشکده علوم انسانی و اجتماعی، دانشگاه گلستان، گرگان، ایران

چکیده

هدف: بیماری آلزایمر یک اختلال نورودژنراتیو پیشرونده است که با زوال تدریجی عملکردهای شناختی، به‌ویژه حافظه و یادگیری، مشخص می‌شود. نوروتروفین‌ها به عنوان مولکول‌های کلیدی در تنظیم و حمایت از رشد و بقای نورون‌ها شناخته می‌شوند. فعالیت ورزشی می‌تواند از طریق مکانیسم‌های پیچیده‌ای همچون کاهش التهاب، افزایش جریان خون مغزی، و تنظیم متابولیسم انرژی بر این نوروتروفین ها اثرگذار باشد. با این حال، هنوز نقش فعالیت ورزشی در این بیماران بطور کامل روشن نیست و نتایج ضد و نقیضی گزارش شده است و نیاز به تحقیقات بیشتری در این زمینه احساس می‌شود. لذا هدف از مطالعه حاضر، بررسی نقش فعالیت ورزشی بر فاکتور نوروتروفیک مشتق مغزی و فاکتور رشد عصبی در بیماران مبتلا به آلزایمر بصورت مرور نظام‌مند و فراتحلیل می‌باشد. روش پژوهش: مقالات منتشر شده به زبان فارسی و انگلیسی تا سال 2025 از پایگاههای اطلاعاتی Pub Med، Google scholar، Science direct،  SID، Scopus  و Irandoc جستجو و وارد فراتحلیل شدند. مدل‌های اثرات ثابت و تصادفی برای فراتحلیل اندازه اثر متوسط (تفاوت در میانگین با فاصله اطمینان 95 درصد) در پژوهش مربوط به BDNF و NGF به کمک نرم افزار CMA2 انجام شد. یافته‌ها: نتایج فراتحلیل نشان داد که فعالیت ورزشی باعث افزایش سطوح فاکتور نوروتروفیک مشتق مغزی در بیماران آلزایمری می‌گردد (76/0 ES=،29/1 تا 22/0CI= % 95 ، 005/0p=). ولی با این وجود انجام فعالیت ورزشی در سطوح فاکتور رشد عصبی بیماران آلزایمری تغییر معنی‌داری ایجاد نمی‌کند (51/0- ES= ،55/1- تا 51/0 CI=%95، 32/0 p=). نتیجه‌گیری: انجام فعالیت ورزشی با تاثیر بر سطوح فاکتور نوروتروفیک مشتق مغزی می‌تواند نقش مهمی در بیماران آلزایمری داشته باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The role of exercise training on neurotrophic factors associated with Alzheimer's disease: A systematic review with meta-analysis

نویسندگان [English]

  • Yazgaldi Nazari 1
  • Fatemeh Islami 2
1 Assistant professor at Golestan University
2 Department of sports sciences, Faculty of Humanities and social sciences, Golestan University, Gorgan, Iran
چکیده [English]

Aim:       Alzheimer's disease is a progressive neurodegenerative disorder characterized by gradual deterioration of cognitive functions, especially memory and learning. Neurotrophins are known as key molecules in regulating and supporting the growth and survival of neurons. Physical activity can affect these neurotrophins through complex mechanisms such as reducing inflammation, increasing cerebral blood flow, and regulating energy metabolism. However, the role of Physical activity in these patients has not been fully clarified and conflicting results have been reported, and the need for more research in this field is felt. Therefore, the aim of the present study is to investigate the role of exercise on brain-derived neurotrophic factor and nerve growth factor in patients with Alzheimer's disease through a systematic review and meta-analysis. Methods: Articles published in Persian and English until 2025 were searched from Pub Med, Google scholar, Science direct, SID, Scopus and Irandoc databases and included in the meta-analysis. Fixed and random effect models for meta-analysis of average effect size (difference in mean with 95% confidence interval) in the research related to BDNF and NGF were performed with the help of CMA2 software. Results:  The results of meta-analysis showed that Physical activity increases BDNF in Alzheimer's patients (ES=0.76, 95%CI=0.22 to 1.29 , p=0.005). However, doing Physical activity does not cause significant changes in NGF of Alzheimer's patients (ES=-0.51, p=0.32, 95% CI= 0.51 to -1.55). Conclusions:  Doing physical activities with an effect on BDNF can play an important role in Alzheimer's patients

کلیدواژه‌ها [English]

  • Exercise training
  • Brain-derived neurotrophic factor
  • Nerve growth factor
  • Cognitive impairment
  • Alzheimer's disease

مراجع

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مقالات آماده انتشار، پذیرفته شده
انتشار آنلاین از تاریخ 26 مهر 1404

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  • تاریخ دریافت: 06 خرداد 1404
  • تاریخ بازنگری: 15 مهر 1404
  • تاریخ پذیرش: 21 مهر 1404

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