نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
1 گروه تربیت بدنی و علوم ورزشی، واحد محلات، دانشگاه آزاد اسلامی، محلات، ایران.
2 گروه فیزیولوژی ورزشی، واحد اراک، دانشگاه آزاد اسلامی، اراک، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background: Obesity is associated with the development of non-alcoholic fatty liver disease, which involves the accumulation of fat in the liver and can lead to inflammation and liver fibrosis. Therefore, the aim of the present study was to investigate the effect of aerobic exercise followed by footshock electrical stimulation on the expression of the hepatokines Fet-A and FGF21 in the liver tissue of calorie-restricted obese rats. Methods: In this experimental study, with a control group of 35 male Wistar rats (8 weeks old, weighing 200±19g), after induction of obesity and weight gain, randomly divided into 5 groups of 7: control, fasting-obese, fasting-endurance exercise, fasting-electrical stimulation and Fasting-endurance training-electrical stimulation were divided. Intervention groups for a period of 4 weeks under endurance sports activity (with a speed of 10 to 20 m/min ), electrical stimulation (0.5 mA and 20 minutes) and fasting (8 to 16 hours) were placed. After exercise and anesthesia, brain tissue sampling was done and after molecular processes, gene expression was measured using Real time-PCR machine. For data analysis, two-way analysis of variance test was used at a significance level of p<0.05 and GraphPad software. Results: The results showed that endurance training resulted in a significant increase in the expression of Fet-A genes and a significant decrease in FGF21 in fasted obese rats compared to the control group (P=0.0001). Also, endurance training with stimulation also resulted in a significant increase and decrease in the values of Fet-A and FGF21 genes (P=0.0001). On the other hand, electrical stimulation showed a significant increase in both genes compared to the control group (P=0.0001). Conclusion: It seems that endurance training and electrical stimulation during fasting, by regulating the hepatokines studied in the above research, leads to a reduction in liver damage caused by obesity and their physical health.
کلیدواژهها [English]
)