تاثیر تمرین هوازی تناوبی بر مقدار بیان پروتئین‌های A20 و CYLD قلبی موش‌های نر مدل سکته قلبی

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 گروه فیزیولوژی ورزشی،دانشکده علوم تربیتی و روانشناسی، دانشگاه محقق اردبیلی، اردبیل،ایران

2 دانشیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران

3 3. دانشیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان‌شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.

4 2. استادیار، گروه فیزیولوژی ورزش، دانشکده علوم تربیتی و روان شناسی، دانشگاه محقق اردبیلی، اردبیل، ایران.

چکیده

هدف: آسیب ایسکمی/ خون‌رسانی مجدد میوکارد (MI/RI) یکی از عوامل تعیین‌کننده اختلالات بیماری‌های قلبی عروقی می‌باشد که با مرگ سلولی ناشی از التهاب و اختلال در فعالیت پروتئین‎های دیوبی‌کوئیتینه کننده همراه است. هدف از مطالعه حاضر تعیین تأثیر تمرین هوازی تناوبی بر بیان پروتئین‌های A20 و CYLD در بافت قلب موش‌های نر مدل سکته قلبی بود. روش پژوهش: در مطالعه تجربی حاضر 30 سر موش صحرایی نر نژاد ویستار 16 هفته‌ای با وزن 220 تا 280 گرم به‌طور تصادفی به سه گروه کنترل (سالم)، انفارکتوس میوکارد (MI) و MI+تمرین هوازی تناوبی با شدت متوسط تقسیم شدند. انفارکتوس میوکارد توسط مداخله مستقیم با بستن LAD به مدت‌30 دقیقه انجام شد. پروتکل تمرین هوازی تناوبی با شدت متوسط 60 دقیقه دویدن تناوبی روی تردمیل، هر تناوب شامل 4 دقیقه دویدن با شدت 65 -70 درصد VO2max و 2 دقیقه بازیافت فعال با شدت 50 –60 درصد VO2max، ‌ سه روز در هفته و به مدت 8 هفته انجام شد. به‌منظور بررسی بیان پروتئین‌های A20 و CYLD از روش وسترن بلات استفاده شد. داده‌ها با استفاده از آنالیز واریانس یک‌طرفه و آزمون تعقیبی توکی در سطح معنی‌داری 05/0>p مقایسه شدند.. یافته‌ها: نتیجه آزمون تعقیبی توکی برای متغیر A20 نشان داد که میزان بیان این پروتئین در گروه MI به‌طور معنی‌داری پایین‌تر از گروه کنترل سالم بود (01/0=p). همچنین، میزان بیان پروتئین A20 در گروه تمرین+MI به‌طور معنی‌داری نسبت به گروه MI و کنترل سالم افزایش داشت (به ترتیب:  001/0=p، 03/0=p). نتایج نشان داد هرچند میزان بیان پروتئین CYLD در گروه MI نسبت به گروه کنترل سالم کاهش یافت؛ اما ازنظر آماری معنی‌دار نبود (06/0=p). همچنین، میزان بیان پروتئین CYLD در گروه تمرین+MI نسبت به گروه کنترل سالم و MI افزایش یافت (به ترتیب:  01/0=p، 001/0=p). نتیجه‌گیری: تمرین هوازی تناوبی احتمالاً با افزایش پروتئین‌های A20 و CYLD قلبی و کاهش التهاب، از مرگ سلولی ناشی از آن جلوگیری می‌کند. بااین‌حال، به دلیل کمبود شواهد و محدودیت‌های تحقیق، همچنان نیازمند بررسی‌های بیشتر می‌باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of Aerobic Interval Training on the Expression of Cardiac A20 and CYLD Proteins in a Rat Model of Myocardial Infarction

نویسندگان [English]

  • negar rostami 1
  • Roghayyeh Afroundeh 2
  • Farnaz Seify 3
  • Ameneh Pourrahim Ghoroughchi 4
1 Department of Exercise Physiology, University of Mohaghegh Ardabili, Ardabil, Iran
2 Associate Professor of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
3 Associate Professor of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
4 Assistant Professor of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
چکیده [English]

Aim:       Myocardial ischemia/reperfusion injury (MI/RI) is one of the determining factors of cardiovascular disease disorders, which is associated with cell death caused by inflammation and impaired activity of deubiquitinating proteins. The aim of the present study was to determine the effect of Interval aerobic training on the expression of A20 and CYLD proteins in the heart tissue of male myocardial infarction model mice. Methods: In this experimental study, 30 16-week-old male Wistar rats weighing 220 to 280 gr were randomly divided into three groups: control (healthy), myocardial infarction (MI), and interval training. Myocardial infarction was performed by direct intervention with LAD occlusion for 30 minutes. Interval protocol with moderate intensity of 60 minutes of intermittent running on a treadmill, each interval including 4 minutes of running with an intensity of 65-70% of VO2max and 2 minutes of active recovery with an intensity of 50-60% of VO2max, three days a week and for 8 weeks. Western blotting was used to examine the expression of A20 and CYLD proteins. Data were compared using one-way analysis of variance and Tukey's post hoc test at a significance level of p<0.05. Result: The result of Tukey's post hoc test for the A20 variable showed that the expression level of this protein in the MI group was significantly lower than that of the healthy control group (p=0.01). Also, the expression level of A20 protein in the interval training+MI group was significantly increased compared to the MI group and the healthy control group (p=0.001, p=0.03, respectively). The results showed that although the expression level of CYLD protein in the MI group was reduced compared to the healthy control group; but it was not statistically significant (p=0.06). Also, the expression level of CYLD protein in the interval training+MI group was increased compared to the healthy control and MI groups (p=0.01, p=0.001, respectively). Conclusion: Interval aerobic training may prevent inflammation-induced cell death by increasing the expression of cardiac A20 and CYLD proteins. Therefore, Interval aerobic training can be suggested as an effective non-pharmacological intervention in the management and treatment of inflammation associated with myocardial infarction. However, due to the lack of evidence and research limitations, further investigation is still required.

کلیدواژه‌ها [English]

  • Aerobic interval training
  • myocardial infarction
  • A20
  • CYLD

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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 13، شماره 1
فروردین 1405
صفحه 144-155

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  • تاریخ دریافت: 14 اسفند 1403
  • تاریخ بازنگری: 28 اردیبهشت 1404
  • تاریخ پذیرش: 30 اردیبهشت 1404

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