نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
1 گروه تربیت بدنی و علوم ورزشی، دانشگاه تربیت مدرس، تهران، ایران.
2 گروه تربیت بدنی و علوم ورزشی، دانشگاه تربیت مدرس، تهران، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background& purpose: Nowadays, the prevalence of obesity has become a public health concern. Therefore, it is necessary to investigate precise treatment strategies and simultaneously investigate the mechanisms involved. The present study aimed to examine the effect of a high-intensity interval training course on the expression of FGF21 in the soleus muscle and lipid profile in rats fed a high-fat diet. Methods: For this purpose, 24 healthy adult male rats were randomly divided into four groups: control (CON) (N=6), control+exercise (CON+EXE) (N=6), high-fat diet (HFD) (N=6), and high-fat diet+exercise (HFD+EXE) (N=6). Diet and exercise interventions were initiated simultaneously and continued for 10 weeks. HIIT training consisted of eight periods of interval activity (90% MRC for 2.5 min) with active rest periods (50% MRC) for 2.5 min). The PCR_ method was used to examine FGF21 expression in the soleus muscle. Serum lipid indices were also measured. Shapiro-Wilk test was used to examine the normality of the data distribution, and one-way ANOVA was used to analyze the data. Tukey's post hoc test was also used to study pairwise groups. The significance level was set at P<0.05, and statistical analyses were performed using SPSS27 software. Results: By performing HIIT, weight and BMI were reduced, and LDL, cholesterol, HDL, and HDL/LDL ratio were increased in the training groups compared to those in the control group (P=0.001). The expression of FGF21 in the soleus muscle was significantly higher in the training group than in the control group (P=0.001). Conclusions: Ten weeks of HIIT without caloric restriction could potentially increase FGF21 expression and improve lipid profiles and weight loss. Therefore, this type of training can modulate and regulate obesity and its complications, without caloric restriction.
کلیدواژهها [English]
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