نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
1 کارشناسی ارشد فیزیولوژی ورزشی ، گروه تربیت بدنی و علوم ورزشی ، دانشگاه پیام نور، مرکز کرج، ایران
2 گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه پیام نور، تهران، ایران
3 گروه تربیت بدنی و علوم ورزشی، دانشگاه پیام نور، تهران، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and purpose: The positive effects of exercise training on mood and behavioral disorders in Alzheimer's patients as a non-pharmacological approach are of interest to researchers.The purpose of this study was to investigate the effect of aerobic training on the level of anxiety and serotonin levels in the hippocampus, and prefrontal cortex in rats with Alzheimer's Disease. Method: 40 male Wistar rats (80-90 days, 237±33 grams) were randomly divided into four groups (N=10):control, training, Alzheimer, and Alzheimer+training.They had two weeks of adaptation to the environment and 12 weeks of aerobic training on the treadmill.The Alzheimer's disease model was created at the end of the ninth week by injecting 3 mg/kg of streptozocin into the ventricular region of the brain. After disease induction, aerobic exercise was continued for three weeks. At the end of the training period, the dark and light box test was performed to estimate the anxiety level of the rats, then to separate the hippocampus and prefrontal areas, and finally to measure the amount of serotonin using the MyBio kit and the ELISA technique.To analyze the data, one-way ANOVA with Tukey's post-hoc test (P<0.05) was performed by SPSS software. Results: The anxiety level of the rats in the Alzheimer+training was significantly reduced compared to the Alzheimer's group (P=0.001).The average time and number of people entering the light section was higher than that of the Alzheimer's group.Serotonin levels in the prefrontal region of the Alzheimer+training group increased significantly compared to the Alzheimer's group (P=0.001).However, this increase was insignificant in the hippocampus region (P=0.149).None of the variables showed a significant difference between Alzheimer+training and the healthy training groups (P>0.05). Conclusion:Having an active lifestyle and performing aerobic exercise, through increasing the secretion of serotonin hormone in the pre-frontal cortex of the brain, reduces the anxiety level of rats with Alzheimer's disease.
کلیدواژه‌ها [English]
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