نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
دانشکده تربیت بدنی و علوم ورزشی، دانشگاه گیلان، رشت، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and Objective: Cognitive decline is a common complication of diabetes that is inadequately addressed by existing treatments. This study investigated the synergistic effects of selenium nanoparticles (SeNPs) and high-intensity interval training (HIIT) on cognitive function and neuroprotection in a diabetic rat model. Methods: Male rats (n=31) were induced with diabetes and divided into five groups: control, placebo, treatment with SeNPs (supplement), HIIT (exercise), and combined treatment of SeNPs and HIIT (supplement + excersie). Cognitive function was assessed using the Morris water maze test, and irisin receptor expression and brain-derived neurotrophic factor (BDNF) protein levels were assessed to assess neuroprotective effects. Results: The results showed that both SeNPs and HIIT significantly enhanced learning and memory and also provided neuroprotective benefits. Notably, treatment groups showed increased expression of irisin receptor in the hippocampus and increased BDNF levels compared to control groups. Conclusion: The combination of SeNPs and HIIT may effectively reduce cognitive decline and promote neuroprotection in diabetic conditions through modulation of irisin and BDNF signaling pathways.
کلیدواژهها [English]
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