تاثیر تمرینات تداومی با شدت متوسط (MICT) بر سطح پلاسمایی دی پپتیدیل پپتیداز 4(DPP4) و WISP-1 در زنان چاق مبتلا به دیابت نوع2

مقالات آماده انتشار

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسنده

گروه علوم ورزشی، دانشکدة علوم انسانی، دانشگاه مراغه، مراغه، ایران

چکیده

هدف: دیابت نوع 2 با افزایش سطح فاکتورهای التهابی سیستمیک همراه است که موجب اختلال در عملکرد انسولین می­شود بنابراین هدف از تحقیق حاضر بررسی تاثیر تمرین تناوبی با شدت متوسط بر سطح سرمی دی پپتیدیل پپتیداز 4 و WISP-1 در زنان چاق مبتلا به دیابت نوع2 بود. روش شناسی: پژوهش حاضر از نوع نیمه تجربی با طرح پیش آزمون و پس آزمون بود. جامعه­ی آماری شامل 40 زن چاق مبتلا به دیابت نوع 2 با میانگین سنی 32/1±2/43 و میانگین شاخص تود                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ه بدنی 74/0±1/30  کیلوگرم بر متر مربع بودند. آزمودنی­ها به طور تصادفی در دو گروه 20 نفری تجربی و کنترل قرار گرفتند. گروه تجربی، تمرینات تناوبی با شدت متوسط را با شدت 60 درصد ضربان قلب ذخیره  و به مدت 12 هفته، هفته­ای سه جلسه 60 دقیقه­ای انجام دادند. قبل و بعد از تمرین شاخص­های ترکیب­بدنی و بیوشیمیایی سنجش شدند. از تحلیل واریانس دو طرفه و تی زوجی برای تحلیل داده­ها استفاده شد.  یافته‌ها: نتایج تحقیق حاضر نشان داد که تفاوت معنی­داری در سطوح سرمی DPP-4 (001/0p=) و WISP-1 (001/0p=)، وزن بدن (001/0p=) و شاخص توده بوده (001/0p=) بین گروه تجربی در مقایسه با گروه کنترل وجود داشت. همچنین 12 هفته تمرین تناوبی با شدت متوسط منجر به کاهش معنی­دار DPP-4 ( 001/0p=) و WISP-1 (001/0p=)، وزن بدن (001/0p=) و شاخص توده بدنی (001/0p=) در پس آزمون در مقایسه با پیش آزمون می­گردد. علاوه بر این ارتباط معنی­داری بین تغییرات غلظت DPP-4 و WISP-1 بعد از 12 هفته تمرینات تناوبی با شدت متوسط وجود داشت (001/0p=). نتیجه‌گیری: به نظر می­رسد انجام تمرینات تناوبی با شدت متوسط  با تعدیل سایتوکین­های پیش التهابی از جمله DPP-4  و WISP-1 تاثیر معناداری بر عوامل موثر در بهبود شرایط بیماری دیابت نوع 2 دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of moderate intensity continuous training (MICT) on the plasma level of dipeptidyl peptidase 4 (DPP4) and WISP-1 in obese women with type 2 diabetes

نویسنده [English]

  • solmaz babaei
Department of Sports Sciences, Faculty of Humanities, University of Maragheh, Maragheh, Iran.
چکیده [English]

Aim:      The study aimed to investigate the impact of moderate-intensity interval training on serum levels of Dipeptidyl Peptidase-4 (DPP-4) and WISP-1 in obese women with type 2 diabetes.Methodology:This semi-experimental research utilized a pre-test and post-test design. The sample consisted of 40 obese women diagnosed with type 2 diabetes, with a body mass index (BMI) of 30.1 ± 0.74 kg/m². Participants were randomly divided into two groups of 20: an experimental group and a control group. The experimental group engaged in moderate-intensity interval training at 60% of their heart rate reserve for 12 weeks, attending three 60-minute sessions each week. Body composition and biochemical markers were assessed before and after the training program. Data analysis was conducted using two-way ANOVA and paired t-tests.Result:The results indicated significant differences in serum levels of DPP-4 (p = 0.001) and WISP-1 (p = 0.001), body weight (p = 0.001), and BMI (p = 0.001) between the experimental and control groups. Additionally, after 12 weeks of moderate-intensity interval training, there was a significant reduction in DPP-4 (p = 0.001) and WISP-1 levels (p = 0.001), body weight (p = 0.001), and BMI (p = 0.001) in the post-test compared to the pre-test. A significant correlation was also found between the changes in DPP-4 and WISP-1 concentrations after the training period (p = 0.001).Conclusion: The findings suggest that moderate-intensity interval training significantly modulates pro-inflammatory cytokines such as DPP-4 and WISP-1, indicating a meaningful impact on factors influencing the management of type 2 diabetes conditions.
 

کلیدواژه‌ها [English]

  • moderate intensity interval training
  • DPP-4
  • WISP-1
  • obese women
  • type 2 diabetes

مراجع

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انتشار آنلاین از تاریخ 18 دی 1403

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  • تاریخ دریافت: 02 آبان 1403
  • تاریخ بازنگری: 17 دی 1403
  • تاریخ پذیرش: 17 دی 1403

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