نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
1 دانشجوی دکتری فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران.
2 دانشیار گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز
3 استادیار گروه علوم پایه، دانشکده دامپزشکی، علوم پزشکی تبریز، دانشگاه آزاد اسلامی، تبریز، ایران.
4 استادیار گروه فیزیولوژی ورزشی، گروه تربیت‌بدنی و علوم ورزشی، دانشکده علوم اجتماعی، دانشگاه بین المللی امام خمینی(ره) ، قزوین، ایران
5 استاد گروه پاتوبیولوژی، دانشکده دامپزشکی، علوم پزشکی تبریز، دانشگاه آزاد اسلامی، تبریز، ایران.
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and purpose: Parkinson's disease is a neurodegenerative disease characterized by the destruction of dopaminergic neurons in the substantia nigra region of the brain. Alpha-synuclein is a protein that forms plaques called Lewy bodies in Parkinson's disease and is considered the main cause of brain tissue damage. The purpose of the present study was to determine the effect of an intense interval training period and acetyl-L-carnitine (ALC) supplementation on alpha-synuclein and thioredoxin (TRX) protein levels in the brains of 6-hydroxydopamine-induced parkinsonian rats. Research method: The statistical population of this study included 36 Wistar male rats, which were randomly divided into 6 equal groups: healthy control group, sham surgery group, Parkinson's control group, Parkinson's exercise group, Parkinson's supplement group, Parkinson's exercise and supplement group. This experimental research was carried out during 12 weeks of training and the drug receiving groups received ALC supplement once a day for 12 weeks with a dose of 100 mg/kg by gavage. Behavioral tests were performed to confirm the creation of the Parkinsonian model. Tissue samples were obtained 48 hours after the last exercise program. Results: The findings showed that after 12 weeks of HIIT training and ALC consumption, there was a significant difference in TRX (P=0.001) and alpha-synuclein (P=0.001) values between the study groups. The results of the follow-up test showed that the values of TRX and alpha-synuclein in the exercise+supplement group increased (P=0.001) and decreased (P=0.002) respectively, compared to the Parkinson's control group. There was no significant difference in the values of alpha-synuclein in the training (p=0.114) and supplement (p=0.325) groups compared to the Parkinson's control group. Conclusion: Intense intermittent exercise with ALC supplement may be effective in improving cell damage and function of Parkinson's patients by modulating some oxidative regulatory pathways, including increasing TRX antioxidant enzyme and reducing brain tissue alpha-synuclein accumulation.
کلیدواژه‌ها [English]
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