نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I
نویسندگان
1 دانشکده علوم ورزشی دانشگاه ارومیه
2 دانشیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران.
3 استادیار فیزیولوژی ورزشی، گروه فیزلوژی ورزشی، دانشکده علوم ورزشی، دانشگاه ارومیه، ارومیه، ایران
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background& purpose: Activation of AMPK signaling following exercise is widely associated with the muscle atrophy pathway. The aim of this study was to investigate the comparison of the efficacy of 12 weeks resistance training and combined on the activation of AMPK signaling, muscle glycogen and ATP levels, and gene expression of muscle atrophy markers in middle-aged women. Methods: For this purpose, 30 untrained middle-aged women with 40-60 years were randomly divided into 3 groups of incremental resistance training, combined resistance and high intensity interval training, and control. Resistance training protocol included 6 exercises with 3 sets of 5-7 repetitions with 90 seconds rest, and the intensity was 50-80%1RM. high intensity interval training protocol was performed in 5 one-minute interval with an intensity of 60-90% of the maximum heart rate with 2-3 minutes of active rest between each interval, and resistance training included 4 movements in 3 sets with a 90-second rest interval and the number was 5-7 repetitions and the intensity was 50-80% of 1RM. A tissue sample was taken from the vastus lateralis muscle. The difference between the pre-test and post-test data between the groups was evaluated using one-way analysis of variance and Tukey's post hoc test at a significance level of P≤0.05. Results: The results showed that muscle glycogen concentration and ATP levels had insignificant changes after 12 weeks of exercise training (P=0.07). Also, the results showed that muscle AMPK levels decreased significantly after 12 weeks of resistance and combined training (P=0.005). The gene expression of Atrogin-1/MAFbx, MuRF-1 and FOXO3a in muscle decreased significantly after 12 weeks of resistance training (P=0.01). Conclusions: Although there was no difference between the combined and resistance training groups in all variables. However, the effect of resistance training in reducing of AMPK and muscle atrophy genes expression was stronger.
کلیدواژه‌ها [English]
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