تأثیر یادگیری شطرنج و مصرف مکمل امگا-3 بر سطوح سرمی NT-3 و گیرنده TrkC در زنان سالمند

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 دانشگاه ازاد اسلامی واحد بجنورد

2 گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد واحد بجنورد، بجنورد، ایران

3 دانشجوی دکتری فیزیولوژی ورزشی- دانشگاه ازاد اسلامی واحد بجنورد

چکیده

هدف: سالمندی، دوره‌ای است که علاوه‌بر مشکلات جسمی با اختلالات رفتاری، شناختی و حرکتی همراه است. نوروتروفین-3 (NT-3) یک عامل نوروتروفیک است که عمدتاً به گیرنده تروپومیوزین کیناز C (trkC) متصل می‌شود. نشان داده شده است که NT-3 دارای اثرات محافظت کننده عصبی در ایسکمی کانونی مغزی است. پژوهش حاضر به بررسی تأثیر یادگیری شطرنج و مصرف مکمل امگا-3 بر سطوح سرمی نوروتروفین-3  و گیرنده تروپومیوزین کیناز C در زنان سالمند می‌پردازد. روش شناسی: در این مطالعه 20 نفر از زنان سالمند شهرستان بجنورد در بازه سنی 50 تا 70 سال به‌طور تصادفی به چهار گروه کنترل، شطرنج، مکمل امگا-3 و شطرنج+مکمل امگا-3 تقسیم شدند. آزمودنی‌ها درگروه شطرنج به مدت 8 هفته و 3 روز در هفته به یادگیری شطرنج پرداختند. مقدار مصرف روزانه مکمل امگا-3، دو هزار میلی‌گرم بود.  نمونه‌گیری خون در دو نوبت پیش‌آزمون و پس آزمون و به میزان 5 میلی‌لیتر از ورید بازویی آزمودنی‌ها در حالت نشسته انجام شد. اندازه‌گیری مقادیر نوروتروفین-3 و گیرنده تروپومیوزین کیناز C توسط کیت الایزا مخصوص نمونه‌های انسانی انجام شد. داده‌ها با استفاده از آزمون آنالیز واریانس یک‌طرفه و آزمون تعقیبی توکی در سطح معناداری کمتر از 05/0 تجزیه و تحلیل شدند. یافته‌ها: نتایج پژوهش حاضر افزایش معنادار سطوح سرمی نوروتروفین-3 و گیرنده تروپومیوزین کیناز C را در گروه‌های شطرنج، مکمل امگا-3 و شطرنج+مکمل امگا-3 را در مقایسه با گروه کنترل نشان داد (05/0≥p). نتیجه‌گیری: با توجه به نتایج پژوهش حاضر می‌توان با یادگیری شطرنج و مصرف مکمل امگا-3، به بهبود فرایندهایی همچون یادگیری، حافظه و عملکردشناختی و همچنین تاثیر مثبت بر فاکتورهای رشد عصبی و وضعیت بدنی در سالمندی دست یافت.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of chess learning and omega-3 supplementation on serum levels of NT-3 and TrkC receptor in elderly women

نویسندگان [English]

  • Maliheh Yazdizadeh 1
  • Sadegh Cheragh-Birjandi 2
  • sara Asghari 3
1 bojnurd
2 Department of Physical Education, Isalmic Azad University, Bojnourd branch, Bojnourd, Iran
3 PhD Candidate in Sports Physiology - Islamic Azad University, Bojnord Branch
چکیده [English]

Aim:      Old age is a period that is accompanied by behavioral, cognitive and movement disorders in addition to physical problems. Neurotrophin-3 (NT-3) is a neurotrophic factor that mainly binds to the receptor tropomyosin kinase C (trkC). NT-3 has been shown to have neuroprotective effects in focal cerebral ischemia. The present study examines the effect of learning chess and consuming omega-3 supplements on the serum levels of neurotrophin-3 and tropomyosin kinase C receptor in elderly women.Methods:   In this study, 20 elderly women of Bojnord city between the ages of 50 and 70 were randomly divided into four control groups, chess, omega-3 supplement and chess + omega-3 supplement. Subjects in the chess group learned chess for 8 weeks and 3 days a week. The daily intake of omega-3 supplements was two thousand milligrams. Blood sampling was done on two occasions, pre-test and post-test, in the amount of 5 ml from the subjects' brachial vein while sitting. Neurotrophin-3 and tropomyosin kinase C receptor values ​​were measured by ELISA kit for human samples. The data were analyzed using one-way analysis of variance and Tukey's post hoc test at a significance level of less than 0.05.Results: The results of the present study showed a significant increase in the serum levels of neurotrophin-3 and tropomyosin kinase C receptor in chess, omega-3 supplement and chess+omega-3 supplement groups compared to the control group (p≤0.05). Conclusions:    According to the results of the present study, by learning chess and consuming omega-3 supplements, it is possible to improve processes such as learning, memory, and cognitive performance, as well as having a positive effect on neural growth factors and physical condition in old age.

کلیدواژه‌ها [English]

  • Chess
  • Omega-3 Supplements
  • Neurotrophin-3
  • Tropomyosin receptor kinase C

مراجع

  1. 1. Kazeminia M, Salari N, Vaisi-Raygani A, Jalali R, Abdi A, Mohammadi M, et al. The effect of exercise on anxiety in the elderly worldwide: a systematic review and meta-analysis. Health and quality of life outcomes. 2020;18(1):1-8.
  2. 2. Ozes B, Tong L, Myers M, Moss K, Ridgley A, Sahenk Z. AAV1. NT-3 gene therapy prevents age-related sarcopenia. Aging (Albany NY). 2023;15(5):1306.
  3. 3. Numakawa T, Odaka H. The role of neurotrophin signaling in age-related cognitive decline and cognitive diseases. International Journal of Molecular Sciences. 2022;23(14):7726.
  4. 4. Naito Y, Lee AK, Takahashi H. Emerging roles of the neurotrophin receptor TrkC in synapse organization. Neuroscience research. 2017;116:10-7.
  5. 5. Moghanlou AE, Yazdanian M, Roshani S, Demirli A, Seydyousefi M, Metz GA, et al. Neuroprotective effects of pre-ischemic exercise are linked to expression of NT-3/NT-4 and TrkB/TrkC in rats. Brain Research Bulletin. 2023;194:54-63.
  6. 6. Smits LL, van Harten AC, Pijnenburg YA, Koedam EL, Bouwman FH, Sistermans N, et al. Trajectories of cognitive decline in different types of dementia. Psychological medicine. 2015;45(5):1051-9.
  7. 7. Golzari A, Parsa Ziabari H, Rostamipour M. The effect of mind-body training with cognitive-motor approach on executive functions of elderly with cognitive processing disorder. journal of motor and behavioral sciences. 2019;2(2):169-76. [In Persian]
  8. 8. Haase M, Loebel J-M, editors. Increasing Quality of Life by Playing Chess: A Blended Care Approach for Elderly People. International Conference on Human-Computer Interaction; 2023: Springer.
  9. 9. Mikhaylova IV, Medvedev IN, Makurina ON, Bakulina ED, Ereshko NY, Eremin MV. The effect of playing chess on an aging or pathological organism. Journal of Biochemical Technology. 2021;12(3-2021):47-52.
  10. 10. Sari-Sarraf V, Vakili J, Tabatabaei SM, Golizadeh A. The effect of 12 weeks of chess-based training under time pressure on some electroencephalographic and skill indices in chess players. Journal of Sport and Exercise Physiology. 2024;16(4):98-111. [In Persian]
  11. 11. Czech J, Willig M, Beyer A, Kersting K, Fürnkranz J. Learning to play the chess variant Crazyhouse above world champion level with deep neural networks and human data. Frontiers in artificial intelligence. 2020;3:24.
  12. 12. Tseng W-J, Chen J-C, Wu I, Wei T. Comparison Training for Computer Chinese Chess. arXiv preprint arXiv:180107411. 2018.
  13. 13. Mochamat, Cuhls H, Marinova M, Kaasa S, Stieber C, Conrad R, et al. A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project. Journal of cachexia, sarcopenia and muscle. 2017;8(1):25-39.
  14. 14. Hassani A, Ghorbani M. Effects of combined exercises beside consumption of omega-3, L-carnitine supplements on the serum level of Irisin, resistance insulin, profile lipid of type 2 diabetic women. Journal of Knowledge & Health. 2018;13(1):55-64. [In Persian]
  15. 15. Ajith TA. A recent update on the effects of omega-3 fatty acids in Alzheimer's disease. Current clinical pharmacology. 2018;13(4):252-60.
  16. 16. Sugasini D, Yalagala PC, Subbaiah PV. Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain. Scientific Reports. 2020;10(1):10809.
  17. 17. Lin P-Y, Cheng C, Satyanarayanan SK, Chiu L-T, Chien Y-C, Chuu C-P, et al. Omega-3 fatty acids and blood-based biomarkers in Alzheimer’s disease and mild cognitive impairment: A randomized placebo-controlled trial. Brain, behavior, and immunity. 2022;99:289-98.
  18. 18. Ziaei S, Mohammadi S, Hasani M, Morvaridi M, Belančić A, Daneshzad E, et al. A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF). Nutritional neuroscience. 2023:1-11. [In Persian]
  19. 19. Gharari Arefi R, Saghebjoo M, Hedayati M, Fathi R. The effect of aerobic training and omega-3 consumption on brain-derived neurotrophic factor in the hippocampus of male rats with homocysteine induced Alzheimer's disease. Scientific Journal of Kurdistan University of Medical Sciences. 2016;21(2):53-64.. [In Persian]
  20. 20. Jamshidi F. The Effect of Chess Education on Perceived Problem Solving and Emotional Intelligenceamong Female Students with Dyscalculia. Journal of Psychology New Ideas. 2021;7(11):1-16. [In Persian]
  21. 21. Dadash Nejad F, Gholami M, Soheili S. The effect of eight-week combined exercise training (resistance-endurance) and Omega-3 ingestion on the levels of fetuin-A and metabolic profile in obese elderly women. Daneshvar Medicine. 2020;27(4):35-44. [In Persian]
  22. 22. Ashofteh A, Cheragh-Birjandi S, TaheriChadorneshin H. The effect of resistance trainings along with Royal jelly supplementation on gene expression of nerve growth factor and tyrosine kinase A receptor in the hippocampal tissue of Alzheimer’s male rats. Journal of Practical Studies of Biosciences in Sport. 2022;10(21):78-89. [In Persian]
  23. 23. Jafarzadeh G, Shakeryan S, Farbood Y, Ghanbarzadeh M. Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats. Journal of Advanced Biomedical Sciences. 2018;8(4):1167-76.. [In Persian]
  24. 24. Shabkhiz F, Mojtahedi S, Akbarnejad Gharehlou A, Amirshaghaghi F. Effects of two types of continues and interval endurance training on protein levels of brain derived neurotrophic factor and tyrosine kinase B receptor in the hippocampus of adult male rats. Journal of Practical Studies of Biosciences in Sport. 2021;9(18):48-57. [In Persian]
  25. 25. Ziaee Bashirzad M, Cheragh-Birjandi S, Younessi HERAVI MA, Salarinia R. The effect of four weeks of different aerobic exercises on the gene expression of tropomyosin kinase B receptor and phosphatidyl-inositol-3-kinase in hippocampal rats with spinal cord injury. Journal of Practical Studies of Biosciences in Sport. 2024. [In Persian]
  26. 26. Dinarvandi F, Sharifi H, Valipour Dehnou V, Khosravi A. Effect of two weeks of sprint interval training combined with omega-3 consumption on serum levels of Irisin, BDNF and Lipid profile in overweight girls. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2020;23(10):72-81. [In Persian]
  27. 27. Taherie Torbatie HR, Khodashenas M, Saberie Kakhkie A. Comparison of the effect of selected chess training programs on working memory, inhibition and attention of children with attention deficit hyperactivity disorder: with emphasis on inhibition and non-inhibition. Mind, Movement, and Behavior. 2024;2(2). [In Persian]
  28. 28. Schaeffer E, Roeben B, Granert O, Hanert A, Liepelt‐Scarfone I, Leks E, et al. Effects of exergaming on hippocampal volume and brain‐derived neurotrophic factor levels in Parkinson’s disease. European journal of neurology. 2022;29(2):441-9.
  29. 29. Puladian M, Ayatizadeh Tafti F, Samadi H. COMPARISON OF THE EFFECT OF MINDFULNESS EXERCISES AND PETTLEP MENTAL IMAGERY ON THE BALANCE AND CONTINUOUS ATTENTION OF ELDERLY WOMEN. Studies in Medical Sciences. 2023;34(5):278-89. [In Persian]
  30. 30. Eslami R, Gharakhanlou R, Kazemi A, Dabaghzadeh R. Effect of a session resistance exercise on mRNA expression of NT-3 and TrkC proteins in soleus muscle of Wistar rats. Journal of Gorgan University of Medical Sciences. 2015;17(3):63-8. [In Persian]
  31. 31. Akbari F, Moghadasi M, Farsi SF, Edalatmanesh MA. The effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor and tyrosine kinase B receptor gene expression in the rats with hippocampal degeneration model. Metabolism and Exercise. 2019;9(2):137-47.. [In Persian]

32a.        Jeong J-E, Paik S-H, Choi MR, Cho H, Choi J-S, Choi S-W, et al. Altered plasma levels of glial cell line-derived neurotrophic factor in patients with internet gaming disorder: a case-control, pilot study. Psychiatry Investigation. 2019;16(6):469.

 

مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 12، شماره 1
فروردین 1404
صفحه 40-51

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  • تاریخ دریافت: 16 فروردین 1403
  • تاریخ بازنگری: 13 خرداد 1403
  • تاریخ پذیرش: 14 خرداد 1403

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