تاثیر تمرینات ورزشی بر سطوح سرمی آدیپوکین‌های مرتبط با هومئوستاز انرژی (آدروپین، آسپروسین) و مقاومت به انسولین در بیماران مبتلا به دیابت نوع دو یا چاقی: مروری سیستماتیک و متاآنالیز

نوع مقاله : مقاله مروری Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزش، گروه تربیت بدنی و علوم ورزشی، دانشگاه یاسوج، یاسوج، ایران.

2 استاد، گروه علوم ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران.

3 دانشیار، گروه علوم ورزشی، واحد شیراز دانشگاه آزاد اسلامی، شیراز، ایران.

چکیده

هدف: فعالیت بدنی به عنوان یک راهکار عملی نقش مهمی در افزایش آدروپین و کاهش آسپروسین و  بهبود مقاومت به انسولین و پیشگیری از عوارض چاقی و اضافه وزن دارند. هدف مطالعه حاضر، بررسی اثرات فعالیت بدنی بر سطوح سرمی آدیپوکین‌های مرتبط با هومئوستاز انرژی (آدروپین، آسپروسین) و مقاومت به انسولین در بیماران مبتلا به دیابت نوع دو یا چاقی بود. روش شناسی: جستجوی سیستماتیک مقالات انگلیسی و فارسی منتشر شده از پایگاه‌های اطلاعاتیPubMed ،Web of Science ، SID و Magiran تا آکتبر سال 2023 انجام شد. فراتحلیل برای بررسی اثر فعالیت بدنی بر سطوح سرمی آدیپوکین‌های مرتبط با هومئوستاز انرژی (آدروپین، آسپروسین) و مقاومت به انسولین در بیماران مبتلا به دیابت نوع دو یا چاقی انجام شد. تفاوت میانگین و فاصله اطمینان 95% (CI) با استفاده از مدل اثر تصادفی محاسبه شد. ناهمگونی با استفاده از آزمون (I2) و سوگیری انتشار با تحلیل بصری فونل پلات و آزمون Egger بررسی شدند. یافته‌ها: در مجموع 15 مطالعه شامل 16 مداخله ورزشی و 343 آزمودنی در بیماران مبتلا به دیابت نوع دو یا چاقی فراتحلیل شدند. نتایج نشان داد که تمرینات ورزشی سبب افزایش معنادار آدروپین سرمی ]001/0P=‌، (77/ 0 الی 32/1)  mg/dL05/1=‌[SMD، همچنین سبب کاهش معنادار آسپروسین سرمی ]001/0P=‌، (38/1- الی 46/0-)  mg/dL92/0-=‌[SMD، گلوکز ناشتا ]001/0P=‌، (97/0- الی45/0-) mg/dL71/0-=‌[SM، انسولین ]001/0P=‌، (86/0- الی 32/0-)  mg/dL59/0-= [SMDو HOMA-IR ]001/0P=‌، (99/0- الی 47/0-)  mg/dL73/0-= [SMDنسبت به گروه کنترل در بیماران مبتلا به دیابت نوع دو یا چاقی شد. نتیجه‌گیری: نتایج مطالعه حاضر نشان داد که تمرینات هوازی بیشترین تاثیر را در افزایش آدروپین و کاهش در آسپروسین، گلوکز ناشتا، انسولین و مقاومت به انسولین نسبت به تمرینات مقاومتی و ترکیبی داشته است. تمرینات ورزشی سبب کاهش مقاومت به انسولین در مردان دارای اضافه وزن منجر به پیشگیری از بیماری‌های دیابت و قلبی - عروقی می‌شود. به نظر می‌رسد تغییرات ایجاد شده در اثر فعالیت بدنی، آدروپین و آسپروسین ایفای نقش می‌کنند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of exercise training on serum levels of adipokines related to energy homeostasis (adropin, asprosin) and insulin resistance in patients with type 2 diabetes or obesity: A Systematic review and meta-Analysis

نویسندگان [English]

  • omid zafarmand 1
  • Mehdi Mogharnasi 2
  • mehrzad moghadasi 3
1 Master of Exercise Physiology, Department of Physical Education and Sports Sciences, University of Yasouj, Yasouj, Iran.
2 Professor, Department of Sports Sciences,University of Birjand, Birjand, Iran.
3 Associate Professor, Department of Sports Sciences, Faculty of Sports Sciences, Islamic Azad University, Shiraz Branch, Shiraz, Iran.
چکیده [English]

Aim:  Physical activity as a practical solution plays an important role in increasing adropin and decreasing asprosin and improving insulin resistance and preventing the complications of obesity and overweight. The aim of this study was to investigate the effects of  Physical activity on the serum levels of adipokines related to energy homeostasis (adropin, asprosin) and insulin resistance in patients with type 2 diabetes or obesity. Methods: A systematic search of English and Farsi articles published in PubMed, Web of Science, SID and Magiran databases was conducted until October 2023. Meta-analysis was performed to investigate the effect of  Physical activity on serum levels of adipokines related to energy homeostasis (adropin, asprosin) and insulin resistance in patients with type 2 diabetes or obesity. Mean difference and 95% confidence interval (CI) were calculated using random effect model. Heterogeneity was evaluated using the (I2) test, and publication bias was evaluated by visual analysis of the funnel plot and Egger's test. Findings: A total of 15 studies including 16 sports interventions and 343 subjects in patients with type 2 diabetes or obesity were meta-analyzed. The results showed that exercise training caused a significant increase in serum adropin [SMD=1.05 mg/dL (1.32 To 0.77), P=0/001], It also caused a significant decrease in serum asprosin [SMD=-0.92 mg/dL (-0.46 To -1.38), P=0/001], fasting glucose [SMD=-0.71 mg/dL (-0.45 To -0.97), P=0/001], Insulin [SMD=-0.59 mg/dL (-0.32 To -0.86), P=0/001] And HOMA-IR [SMD=-0.73 mg/dL (-0.47 To -0.99), P=0/001] compared to the control group in patients with type 2 diabetes or obesity. Conclusions:  The results of the present study showed that aerobic exercises have the greatest effect in increasing adropin and decreases in asprosine, fasting glucose, insulin and insulin resistance compared to resistance and combined exercises. Exercise reduces insulin resistance in overweight men, leading to the prevention of diabetes and cardiovascular diseases. It seems that changes caused by physical activity, adropin and asprosin play a role.

کلیدواژه‌ها [English]

  • Physical activity
  • Adropin
  • Asprosin
  • Insulin Resistance
  • Type 2 diabetes

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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 11، شماره 2
مهر 1403
صفحه 23-43

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  • تاریخ دریافت: 18 دی 1402
  • تاریخ بازنگری: 19 اسفند 1402
  • تاریخ پذیرش: 19 اسفند 1402

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