تاثیر مکمل HMB بر شاخص‌های آسیب عضلانی و ترکیب بدنی پس از فعالیت‌های ورزشی: مطالعه فراتحلیل

نوع مقاله : مقاله مروری Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 گروه فیزیولوژی ورزشی، دانشگاه کردستان، سنندج، ایران

2 دانشگاه آزاد اسلامی، واحد مریوان، گروه تربیت بدنی، مریوان، ایران

3 آموزش و پرورش سنندج

چکیده

هدف: در این فراتحلیل اثر مکمل بتا هیدروکسی متیل بوتیرات (HMB) بر آسیب عضلانی و شاخص­های ترکیب بدنی بررسی شد. روش شناسی: جستجوی سیستماتیک از پایگاه های اطلاعاتی PubMed، Google scholar، Sciencedirect ، SID ، Scopus، IranMedex، Irandoc انجام گرفت تمام کارآزمایی های بالینی کنترل شده تصادفی، که به مصرف مکمل HMB بر شاخص های کراتین کیناز (CK)، لاکتات دهیدروژناز (LDH) و شاخص های ترکیب بدنی، توده چربی (FM)، توده بدون چربی (FFM) و جرم بدن (BM) انتخاب شدند. مدل‌های اثرات ثابت و تصادفی برای فراتحلیل اندازه اثر متوسط (اختلاف در میانگین با فاصله اطمینان 95 درصد)، در پژوهش مربوط به کراتین کیناز (16 پژوهش)، لاکتات دهیدروژناز (14 پژوهش)، توده چربی بدن (17 پژوهش)، توده بدون چربی بدن (20 پژوهش) و وزن بدن (23 پژوهش) به کمک نرم افزار CMA2 انجام شد. یافته‌ها: نتایج فراتحلیل نشان داد که مصرف مکمل  HMB باعث کاهش معنی­دار CK (22/0-=ES، 86/-0 تا 41/0=95% CI، 034/0=p) ، LDH (34/0=ES، 31/0 تا 57/0=% CI95، 022/0=p) و FM (43/0-=ES، 74/0- تا 119/0- =% CI 95، 007/0=p) گردید و با افزایش معنی­دار FFM (31/0-=ES، 007/0 تا 61/0=% CI 95، 045/0=p) همراه بوده است، اما تاثیری بر BM (054/0=ES، 09/0- تا 20/0=% CI 95، 46/0=p) نداشت. نتیجه‌گیری: به طور کلی نتایج فراتحلیل نشان داد که مکمل سازی مزمن HMB باعث کاهش معنادار آنزیم های شاخص آسیب عضلانی مانند CK، LDH بعد از ورزش می شود و همچنین با کاهش معنی دار FM و افزایش FFM همراه بوده است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of beta-hydroxymethylbutyrate (HMB) supplementation on markers of muscle damage and body composition after exercise: a meta-analysis study

نویسندگان [English]

  • mohammad rahman rahimi 1
  • HASSAN FARAJI 2
  • leila rahimi 3
1 Department of Exercise Physiology, University of Kurdistan, Sanandaj, Iran. 2
2 دانشگاه آزاد اسلامی، واحد مریوان، گروه تربیت بدنی، مریوان، ایران
3 Sanandaj Department of Education
چکیده [English]

In this meta-analysis, the effect of beta-hydroxymethylbutyrate (HMB) supplementation on muscle damage and body composition markers was investigated. Method: A systematic search was conducted from PubMed, Google scholar, Sciencedirect, SID, Scopus, IranMedex, Irandoc databases, all randomized controlled clinical trials, which were related to HMB supplementation on creatine kinase (CK), lactate dehydrogenase ( LDH) and body composition indices, fat mass (FM), fat free mass (FFM) and body mass (BM) were selected. Fixed and random effects models for meta-analysis of average effect size (difference in mean with 95% confidence interval), in research related to creatine kinase (16 studies), lactate dehydrogenase (14 studies), body fat mass (17 studies), fat-free mass Body (20 studies) and body weight (23 studies) were done with the help of CMA2 software.  Results: The meta-analysis results showed that HMB supplementation significantly reduced CK (ES = -0.22, 95% CI = -0.86 to 0.41, p = 0.034), LDH (= 0.34) ES, 95% CI = 0.31 to 0.57, p = 0.022) and FM (ES = 0.43, 95% CI - 0.74 to - 0.119, p = 0.007), and it was associated with a significant increase in FFM (ES=0.31, 0.007 to 0.61% CI 95, p=0.045), but there was no effect on BM (ES=0.054, 0.09 -0 to 0.20 =%CI 95, p=0.46). Conclusion: In general, the results of the meta-analysis showed that chronic supplementation of HMB causes a significant decrease in muscle damage index enzymes such as CK and LDH after exercise, and it was also associated with a significant decrease in FM and an increase in FFM.

کلیدواژه‌ها [English]

  • muscle damage
  • beta-hydroxy beta-methylbutyrate
  • creatine kinase
  • lactate dehydrogenase
  • body composition

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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 11، شماره 1
فروردین 1403
صفحه 53-66

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  • تاریخ دریافت: 16 اردیبهشت 1402
  • تاریخ بازنگری: 08 شهریور 1402
  • تاریخ پذیرش: 08 شهریور 1402

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