اثر تمرینات مقاومتی با تراباند بر سطوح سرمی نترین -1 و شاخص مقاومت به انسولین در زنان دارای اضافه وزن و چاق غیرفعال

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 دانشجوی کارشناسی ارشد فیزیولوژی ورزشی، گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران.

2 گروه تربیت بدنی و علوم ورزشی دانشگاه آزاد واحد بجنورد، بجنورد ایران

چکیده

هدف: چاقی با تغییر در تعادل پروتئین­های درگیر در متابولیسم گلوکز در بروز مقاومت به انسولین نقش داشته و تمرینات ورزشی می‌تواند با تاثیر بر چاقی، هموستاز گلوکز را بهبود بخشد. هدف از مطالعه حاضر بررسی تأثیر تمرین مقاومتی با تراباند بر سطوح سرمی نترین -1 و شاخص مقاومت به انسولین در زنان غیرفعال دارای اضافه وزن و چاق بود. روش شناسی: 20 زن چاق (شاخص توده بدنی 01/3±01/32 کیلوگرم بر مترمربع، 43/3±9/44 سال) به طور تصادفی در دو گروه تمرین مقاومتی و کنترل تقسیم شدند. آزمودنی­های گروه تجربی در هشت هفته تمرین مقاومتی با تراباند، چهار جلسه در هفته شرکت کردند. خونگیری جهت اندازه­گیری شاخص­های خونی مورد نظر قبل و 48 ساعت بعد از آخرین جلسه تمرینی انجام شد. تجزیه و تحلیل داده‌ها با استفاده از آزمون تحلیل کوواریانس در سطح معنی­داری کمتر از 05/0 انجام گرفت. یافته‌ها: بین سطوح سرمی نترین-1 (024/0=P) و انسولین (008/0=P)، شاخص مقاومت به انسولین (009/0=P)، وزن (001/0=P) و درصد چربی بدن (001/0=P) در دو گروه کنترل و تمرین تفاوتی معنی‌دار وجود داشت. نتیجه‌گیری: تمرین مقاومتی با تراباند احتمالاً با افزایش سطح سرمی نترین-1 می­تواند موجب کاهش مقاومت به انسولین در زنان دارای اضافه وزن و چاق غیرفعال شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of Resistance Training with Thera-Band on Serum Levels of Netrin-1 and Insulin Resistance Index in Sedentary overweight and Obese Women

نویسندگان [English]

  • Seyedeh Motahareh Aletaha 1
  • Najmeh Rezaeiyan 2
1 MSc student in exercise physiology. Department of physical education, Bojnourd branch, Islamic Azad University, Bojnourd, Iran.
2 Department of Physical Education Islamic Azad University, Bojnourd Branch, Bojnourd, Iran
چکیده [English]

Aim: Obesity leads to insulin resistance by changing the balance of proteins involved in glucose metabolism, and exercise training can improve glucose hemostasis by effecting obesity. The aim of this study was to investigate the effect of resistance training using thera-band on serum levels of Netrin-1 and insulin resistance index (HOMA-IR) in sedentary overweight and obese women. Methods Twenty overweight and obese women (body mass index 32.01±3.01 kg/m2, mean aged 44.9±3.43 years) randomly divided into two groups of resistance training and control. Subjects in experimental group participated in eight weeks of resistance training using thera-band, four sessions per week. Blood samples have been taken before and 48 hours after last training session to measure the blood factors assessed. Data analyzed by Co-Variance and P<0.05 considered significant. Results: Significant differences existed between training and control groups for serum levels of Netrin-1 (P=0.024) and insulin (P=0.008), HOMA-IR (P=0.009), weight (P=0.001) and body fat percent (P=0.001). Conclusions: Resistance training presumably results in decreases in insulin resistance through augmentation of serum Netrin-1 levels in sedentary overweight and obese women.

کلیدواژه‌ها [English]

  • Netrin-1
  • Thera-band Resistance Training
  • Obesity
  • Insulin Resistance

Publisher: Azarbaijan Shahid Madani University          Copyright © The Authors   

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

مراجع

  1. Ogurtsova K, da Rocha Fernandes J, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE, Makaroff LE. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes research and clinical practice. 2017; 128: 40-50.
  2. Zaccardi F, Webb DR, Yates T, Davies MJ. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgraduate medical journal. 2016; 92(1084): 63-69.
  3. Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. The Journal of clinical investigation. 2016; 126(1): 12-22.
  4. Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012; 148(5):852-71.
  5. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science. 1993; 259(5091):87-91.
  6. Makki K, Froguel P, Wolowczuk I. Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. International Scholarly Research Notices. 2013;2013:139239.
  7. Nieto-Vazquez I, Fernández-Veledo S, Krämer DK, Vila-Bedmar R, Garcia-Guerra L, Lorenzo M. Insulin resistance associated to obesity: the link TNF-alpha. Archives of physiology and biochemistry. 2008;114(3):183-94.
  8. Gao S, Zhang X, Qin Y, Xu S, Zhang J, Wang Z, Kong D, Li C. Dual actions of Netrin-1 on islet insulin secretion and immune modulation. Clinical science. 2016;130(21):1901-11.
  9. Bruikman CS, Vreeken D, Hoogeveen RM, Bom MJ, Danad I, Pinto-Sietsma S-J, van Zonneveld AJ, Knaapen P, Hovingh GK, Stroes ESG, van Gils JM. Netrin-1 and the grade of atherosclerosis are inversely correlated in humans. Arteriosclerosis, thrombosis, and vascular biology. 2020;40(2):462-72.
  10. Cechella JL, Leite MR, Dobrachinski F, Da Rocha JT, Carvalho NR, Duarte MM, Soares FAA, Bresciani G, Royes LFF, Zeni G. Moderate swimming exercise and caffeine supplementation reduce the levels of inflammatory cytokines without causing oxidative stress in tissues of middle-aged rats. Amino acids. 2014;46(5):1187-95.
  11. Daliang Z, Lifang Y, Hong F, Lingling Z, Lin W, Dapeng L, Tianshu ZH, Weimin L. Netrin-1 plays a role in the effect of moderate exercise on myocardial fibrosis in rats. PLoS One. 2019;14(2):e0199802.
  12. Liu N, Huang H, Lin F, Chen A, Zhang Y, Chen R, et al. Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia. Neuroscience. 2011;194:349-58.
  13. Ahmadizad S, Ghorbani S, Ghasemikaram M, Bahmanzadeh M. Effects of short-term nonperiodized, linear periodized and daily undulating periodized resistance training on plasma adiponectin, leptin and insulin resistance. Clinical biochemistry. 2014;47(6):417-22.
  14. Theou O, Stathokostas L, Roland KP, Jakobi JM, Patterson C, Vandervoort AA, Jones GR. The effectiveness of exercise interventions for the management of frailty: a systematic review. Journal of aging research. 2011;2011:569194.
  15. Liu C, Ke X, Wang Y, Feng X, Li Q, Zhang Y, Zhu J, Li Q. The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients. BMC endocrine disorders. 2016;16(1):1-5.
  16. Chen J, Cai Q-p, Shen P-j, Yan R-l, Wang C-m, Yang D-j, Fu H-B, Chen X-Y. Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice. 2012; 7(9):e46201.
  17. Yang Y, Szabat M, Bragagnini C, Kott K, Helgason C, Hoffman B, Johnson JD. Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors. Diabetologia. 2011;54:828-42.
  18. Naebi Far S, Afzalpour ME, Saqeb JM, Hedayati M, Shirzai P. The effect of aerobic resistance training on serum levels of C-reactive protein, lipid profile and body composition in overweight women. Modern Care. 2011; 8(4, 32):196-186.
  19. Hagströmer M, Oja P, Sjöström M. The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity. Public health nutrition. 2006;9(6):755-62.
  20. Stensland SH, Margolis S. Simplifying the calculation of body mass index for quick reference. Journal of the American Dietetic Association. 1990;90(6): 1372.
  21. Kraemer WJ, Fleck SJ. Optimizing strength training: disigning nonlinear periodization work out/ chapter 7 assessment. 1st ed. Mike Bahrke JPHMT, editor. United State: Human Kinetics; 2007.
  22. Jackson AS, Pollock ML, Ward A. Generalized equations for predicting body density of women. Medicine and science in sports and exercise. 1980;12(3):175-81.
  23. Siri WE. Body composition from fluid spaces and density: analysis of methods. 1961. Nutrition. 1993; 9(5): 480-91.
  24. Lau DC, Douketis JD, Morrison KM, Hramiak IM, Sharma AM, Ur E. 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]. Cmaj. 2007;176(8):S1-S13.
  25. Brzycki M. Strength testing—predicting a one-rep max from reps-to-fatigue. Journal of physical education, recreation & dance. 1993;64(1):88-90.
  26. Kazemipour N, Faramarzi M, Banitalebi E. The Effect of 12 Weeks of Theraband Resistance Training on IGF-1 and FGF-2 Levels and Their Relationships with Myokines on Bone Mineral Density of Osteosarcopenic Obese Women. Jentashapir Journal of Cellular and Molecular Biology. 2022;13(3):e130641.
  27. Gholami M, Salehi N. The Effect of Eight Weeks of Resistance Training with Dumbbell and Theraband on the Body Composition and Muscular Strength in the Middle-aged Obese Women: a Clinical Trial. Journal of Rafsanjan University of Medical Sciences. 2018;17(9):829-42. [In Persian]
  28. Mathews ST, Singh GP, Ranalletta M, Cintron VJ, Qiang X, Goustin AS, Catherine Jen KL, Charron MJ, Jahnen-Dechent W, Grunberger, G. Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes. 2002;51(8):2450-8.
  29. Yuksel O, Kizildag S, Hosgorler F, Koc B, Kandis S, Guvendi G, Uysal N. Effects of exercise on netrin-1 and TNF-α levels in non-inflammatory conditions. 2020; 27(3): 760-764.
  30. Lin Z, Jin J, Bai W, Li J, Shan X. Netrin-1 prevents the attachment of monocytes to endothelial cells via an anti-inflammatory effect. Molecular immunology. 2018;103:166-72.
  31. Ranganathan PV, Jayakumar C, Mohamed R, Dong Z, Ramesh G. Netrin-1 regulates the inflammatory response of neutrophils and macrophages, and suppresses ischemic acute kidney injury by inhibiting COX-2-mediated PGE2 production. Kidney international. 2013;83(6):1087-98.
  32. Daynes RA, Jones DC. Emerging roles of PPARs in inflammation and immunity. Nature Reviews Immunology. 2002;2(10):748-59.
  33. Shultz SP, Dahiya R, Leong GM, Rowlands DS, Hills AP, Byrne NM. Muscular strength, aerobic capacity, and adipocytokines in obese youth after resistance training: A pilot study. The Australasian medical journal. 2015;8(4):113.
  34. Jorge MLMP, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz ALD, Resende ES, Ropelle ER, Carvalheira JB, Espindola FS, Jorge PT, Espindola FS. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011;60(9):1244-52.
  35. Nikseresht M, Agha-Alinejad H, Azarbayjani MA, Ebrahim K. Effects of nonlinear resistance and aerobic interval training on cytokines and insulin resistance in sedentary men who are obese. The Journal of Strength & Conditioning Research. 2014;28(9):2560-8.
  36. Kolahdouzi S, Baghadam M, Kani-Golzar FA, Saeidi A, Jabbour G, Ayadi A, De Sousa M, Zouita A, BenAbderrahmane A, Zouhal H. Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men. Physiology & behavior. 2019;205:15-21.
  37. Saltiel AR, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease. The Journal of clinical investigation. 2017;127(1):1-4.
  38. Sharma M, Schlegel M, Brown EJ, Sansbury BE, Weinstock A, Afonso MS, et al. Netrin-1 alters adipose tissue macrophage fate and function in obesity. Immunometabolism. 2019;1(2):e190010.
  39. Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496(7446):445-55.
  40. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. The Journal of clinical investigation. 2003;112(12):1796-808.
  41. Langin D, Dicker A, Tavernier G, Hoffstedt J, Mairal A, Rydén M, Arner E, Sicard A, Jenkins CM, Viguerie N, van Harmelen V, Gross RW, Holm C, Viguerie, N. Adipocyte lipases and defect of lipolysis in human obesity. Diabetes. 2005;54(11):3190-7.
  42. Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology. 2005;42(5):987-1000.
  43. Gibala MJ. Using exercise training to understand control of skeletal muscle metabolism. Applied Physiology, Nutrition, and Metabolism. 2017;42(1):108-10.
  44. Romero-Arenas S, Martínez-Pascual M, Alcaraz PE. Impact of resistance circuit training on neuromuscular, cardiorespiratory and body composition adaptations in the elderly. Aging and disease. 2013;4(5):256.
  45. Goodman CA. The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli. Reviews of Physiology, Biochemistry and Pharmacology 166. 2014:43-95.
  46. Pesta DH, Goncalves RL, Madiraju AK, Strasser B, Sparks LM. Resistance training to improve type 2 diabetes: working toward a prescription for the future. Nutrition & metabolism. 2017;14(1):1-10.
  47. McKinsey TA, Zhang C-L, Lu J, Olson EN. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408(6808):106-11.
  48. Hortobágyi T, Dempsey L, Fraser D, Zheng D, Hamilton G, Lambert J, Dohm L. Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans. The Journal of physiology. 2000;524(1):293-304.
  49. Hoseini R, Parvizi Mastali V. Effect of different exercise training on insulin sensitivity: A review article. Feyz. 2021; 25(3): 935-45. [In Persian]
مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 10، شماره 1
فروردین 1402
صفحه 127-140

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  • تاریخ دریافت: 25 آذر 1401
  • تاریخ بازنگری: 01 اسفند 1401
  • تاریخ پذیرش: 01 اسفند 1401

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