The effect of eight weeks of high-intensity interval training (HIIT) and vitamin D supplementation on Serum levels of IGF-1, Myostatin and hypertrophy in older men

Articles in Press

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Associate Professor of Department of Exercise Physiology, Faculty of Sport Sciences, University of Tabriz, Tabriz, Iran

2 Professor of Department of Exercise Physiology, Faculty of Sport Sciences, University of Tabriz, Tabriz, Iran

3 PhD student of Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran

Abstract

Aim: Aging is often associated with progressive loss of muscle mass and strength. high-intensity interval training (HIIT) and vitamin D intake may increase muscle mass, but its mechanism is largely unclear. The aim of the present study was to evaluate effect of eight weeks HIIT and vitamin D supplementation on IGF-1, myostatin and muscular hypertrophy in elderly men. Methods: In a experimental research design, 30 inactive elderly men were selected based on fat percentage and aerobic fitness and were randomly divided into three groups: HIIT, HIIT + vitamin D and control. The HIIT training program was performed for eight weeks, three days a week. The HIIT training program was three days a week with an intensity of more 75% reserve heart rate or equivalent to the Borg pressure index of 17-15. Blood samples were taken from the subjects 48 hours before and after the training and supplementation protocol. One-way analysis of variance were used to compare between-group research variables (P <0.05).Results: The amount of IGF-1 in both exercise groups (P= 0.003) and exercise + vitamin D (P= 0.0001) was significantly increased compared to the control group, but this difference was not significant between the experimental groups (P= 0.6). Also, the amount of myostatin in both exercise (P= 0.006) and exercise + vitamin D (P= 0.0001) groups was significantly lower than the control group, but this difference was not significant between the experimental groups (P= 0.6). Muscle cross-section showed a significant increase in the two groups (P <0.05) but there was no significant difference between the two groups (P= 0.721). Conclusions: It seams HIIT with and without vitamin D increases IGF-1 and muscle cross-section and decreases myostatin. It may reduce muscle atrophy in older men and be effective in older men.

Keywords

Journal of Applied Health Studies in Sport Physiology

Articles in Press, Accepted Manuscript
Available Online from 20 December 2022

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History

  • Receive Date: 17 May 2022
  • Revise Date: 26 July 2022
  • Accept Date: 06 October 2022

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