The effect of eight weeks of high-intensity interval training (HIIT) and vitamin D supplementation on Serum levels of IGF-1, Myostatin and hypertrophy in older men

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Associate Professor of Department of Exercise Physiology, Faculty of Sport Sciences, University of Tabriz, Tabriz, Iran

2 Professor of Department of Exercise Physiology, Faculty of Sport Sciences, University of Tabriz, Tabriz, Iran

3 PhD student of Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran

Abstract

Aim: Aging is often associated with progressive loss of muscle mass and strength. high-intensity interval training (HIIT) and vitamin D intake may increase muscle mass, but its mechanism is largely unclear. The aim of the present study was to evaluate effect of eight weeks HIIT and vitamin D supplementation on IGF-1, myostatin and muscular hypertrophy in elderly men. Methods: In a experimental research design, 30 inactive elderly men were selected based on fat percentage and aerobic fitness and were randomly divided into three groups: HIIT, HIIT + vitamin D and control. The HIIT training program was performed for eight weeks, three days a week. The HIIT training program was three days a week with an intensity of more 75% reserve heart rate or equivalent to the Borg pressure index of 17-15. Blood samples were taken from the subjects 48 hours before and after the training and supplementation protocol. One-way analysis of variance were used to compare between-group research variables (P <0.05).Results: The amount of IGF-1 in both exercise groups (P= 0.003) and exercise + vitamin D (P= 0.0001) was significantly increased compared to the control group, but this difference was not significant between the experimental groups (P= 0.6). Also, the amount of myostatin in both exercise (P= 0.006) and exercise + vitamin D (P= 0.0001) groups was significantly lower than the control group, but this difference was not significant between the experimental groups (P= 0.6). Muscle cross-section showed a significant increase in the two groups (P <0.05) but there was no significant difference between the two groups (P= 0.721). Conclusions: It seams HIIT with and without vitamin D increases IGF-1 and muscle cross-section and decreases myostatin. It may reduce muscle atrophy in older men and be effective in older men.

Keywords



Articles in Press, Accepted Manuscript
Available Online from 20 December 2022
  • Receive Date: 17 May 2022
  • Revise Date: 26 July 2022
  • Accept Date: 06 October 2022