اثرات فعالیت‌های ورزشی تناوبی با شدت بالا و تداومی با شدت متوسط برغلظت نیتریک اکساید پلاسما و سطوح فشار خون پس از فعالیت ورزشی در مردان چاق غیر فعال

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 کارشناس ارشد فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه گیلان، رشت، ایران

2 استادیار فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه گیلان، رشت، ایران

3 استاد فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه گیلان، رشت، ایران

چکیده

هدف: فعالیت ورزشی یکی از مؤثرترین راهکارها در بهبود عملکرد قلب و عروق به شمار می­رود. مطالعه حاضر به منظور بررسی پاسخ­های قلبی عروقی به دنبال فعالیت ورزشی تناوبی با شدت بالا (HIIE) و فعالیت ورزشی تداومی با شدت متوسط ​​(MICE) در مردان چاق غیر فعال انجام شد. روش شناسی: در مطالعه نیمه تجربی حاضر، هشت مرد چاق غیرفعال (سن: 5/2±5/22 سال، شاخص توده بدن 1/1±5/31 کیلوگرم بر متر مربع) با استفاده از طرح متقاطع تصادفی، در سه مداخله HIIE، MICE و کنترل شرکت نمودند. نمونه‌های خونی قبل، بلافاصله و یک ساعت بعد از فعالیت به منظور اندازه­گیری غلظت نیتریک اکساید (NO) گرفته شد، همچنین ضربان قلب و فشار خون قبل، بلافاصله و هر 15 دقیقه به مدت یک ساعت پس از ورزش اندازه‌گیری شد. یافته‌ها: هیچ تغییر معنی‌داری در فاکتورهای همودینامیک و NO در گروه کنترل مشاهده نشد، با این وجود پس از پروتکل‌های HIIE و MICE کاهش معنی‌داری (05/0 p <) در فشار خون سیستولی (SBP) در مقایسه با شرایط پایه مشاهده شد، که این پدیده به دنبال HIIE برای مدت طولانی­تری ادامه یافت. ضربان قلب و NO پس از هر دو پروتکل افزایش قابل توجهی داشتند  (05/0 p <) ، که افزایش NO به دنبال HIIE برای مدت زمان بیشتری حفظ شد. نتیجه‌گیری: به نظر می­رسد شدت تمرین می­تواند یک عامل اثرگذار بر توسعه دوره PEH باشد. همچنین، با توجه به افزایش طولانی­تر NO ناشی از HIIE در مقایسه با MICE می­توان این نکته را مد نظر قرار داد که احتمالاً PEH طولانی­تر پس از HIIE با مکانیسم اتساع عروقی ناشی از NO در ارتباط می­باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Effects of high-intensity interval versus moderate continuous exercise on plasma concentration of nitric oxide and level of blood pressure in inactive obese men

نویسندگان [English]

  • Mohammad Hossein Sakhaei 1
  • Payam Saidie 2
  • Arsalan Damirchi 3
1 MSc of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran
2 Assistant Professor of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran
3 Professor of sport exercise physiology, Faculty of physical education and sports sciences. university of guilan. Rasht, Iran
چکیده [English]

Aim:  Physical activity is one of the most effective ways to improve cardiovascular function. The present study was performed to evaluate cardiovascular responses following high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) in inactive obese men. Methods:  In the present semi-experimental study, eight inactive obese men (age: 22.5 2 2.5 years, body mass index: 31.5 ± 1.5 kg / m2) using a randomized crossover design, participated in three HIIE, MICE and control interventions.  Blood samples were taken before, immediately and one hour after exercise to measure nitric oxide (NO) concentration. Also, heart rate and blood pressure were measured before, immediately and every 15 minutes for one hour after exercises.  Results:  No significant changes in hemodynamic factors and NO were observed in the control group. However, after HIIE and MICE protocols, a significant decrease (p <0.05) in systolic blood pressure (SBP) was observed compared to baseline conditions, which this phenomenon has persisted for a long time following HIIE. Heart rate and NO increased significantly after both protocols (p <0.05), with the increase in NO following HIIE persisting for longer. Conclusion: It seems that training intensity can be an influential factor in the development of PEH. Also, due to the longer increase in NO caused by HIIE compared to MICE, it can be considered that longer PEH after HIIE is probably related to the mechanism of NO-induced vasodilation.

کلیدواژه‌ها [English]

  • Hypotension
  • Vasodilation
  • Obesity
  • Exercise intensity

مراجع

  1. Carmona-Maurici J, Cuello E, Sánchez E, Miñarro A, Rius F, Bueno M, et al. Impact of bariatric surgery on subclinical atherosclerosis in patients with morbid obesity. Surgery for Obesity and Related Diseases. 2020;16(10):1419-28.
  2. Khalafi M, Symonds ME. The impact of high intensity interval training on liver fat content in overweight or obese adults: A meta-analysis. Physiology & Behavior. 2021;236:113416.
  3. Ortega FB, Lavie CJ, Blair SN. Obesity and cardiovascular disease. Circulation research. 2016;118(11):1752-70.
  4. Kotsis V, Stabouli S, Papakatsika S, Rizos Z, Parati G. Mechanisms of obesity-induced hypertension. Hypertension research. 2010;33(5):386-93.
  5. MacDonald JR. Potential causes, mechanisms, and implications of post exercise hypotension. Journal of human hypertension. 2002;16(4):225-36.
  6. Santana HA, Moreira SR, Asano RY, Sales MM, Córdova C, Campbell CS, et al. Exercise intensity modulates nitric oxide and blood pressure responses in hypertensive older women. Aging clinical and experimental research. 2013;25(1):43-8.
  7. Gil-Ortega M, Condezo-Hoyos L, García-Prieto CF, Arribas SM, González MC, Aranguez I, et al. Imbalance between pro and anti-oxidant mechanisms in perivascular adipose tissue aggravates long-term high-fat diet-derived endothelial dysfunction. PloS one. 2014;9(4):e95312.
  8. Naruse K, Rask-Madsen C, Takahara N, Ha S-w, Suzuma K, Way KJ, et al. Activation of vascular protein kinase C-β inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006;55(3):691-8.
  9. Shabkhiz F, Khalafi M, Rosenkranz S, Karimi P, Moghadami K. Resistance training attenuates circulating FGF-21 and myostatin and improves insulin resistance in elderly men with and without type 2 diabetes mellitus: a randomised controlled clinical trial. European Journal of Sport Science. 2021;21(4):636-45.
  10. Schjerve IE, Tyldum GA, Tjønna AE, Stølen T, Loennechen JP, Hansen HE, et al. Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clinical science. 2008;115(9):283-93.
  11. Valaei K, Mehrabani J, Wong A. Effects of l-citrulline supplementation on nitric oxide and antioxidant markers after high-intensity interval exercise in young men: a randomised controlled trial. British Journal of Nutrition. 2022;127(9):1303-12.
  12. Bhupathiraju SN, Hu FB. Epidemiology of obesity and diabetes and their cardiovascular complications. Circulation research. 2016;118(11):1723-35.
  13. Pozza C, Isidori AM. What’s behind the obesity epidemic. Imaging in bariatric surgery: Springer; 2018. p. 1-8.
  14. de Brito LC, Fecchio RY, Peçanha T, Lima A, Halliwill J, de Moraes Forjaz CL. Recommendations in post-exercise hypotension: concerns, best practices and interpretation. International journal of sports medicine. 2019;40(08):487-97.
  15. Kenney MJ, Seals DR. Postexercise hypotension. Key features, mechanisms, and clinical significance. Hypertension. 1993;22(5):653-64.
  16. Khalafi M, Ravasi AA. A comparison of the impact of exercise training with weight loss diet versus weight loss diet alone on blood pressure in individual with overweight or obesity: a systemic review and meta-analysis. Journal of Applied Health Studies in Sport Physiology. 2021;8(1):70-87. [In Persian]
  17. Halliwill JR, Buck TM, Lacewell AN, Romero SA. Postexercise hypotension and sustained postexercise vasodilatation: what happens after we exercise? Experimental physiology. 2013;98(1):7-18.
  18. Cunha GAd, Rios ACS, Moreno JR, Braga PL, Campbell CSG, Simões HG, et al. Post-exercise hypotension in hypertensive individuals submitted to aerobic exercises of alternated intensities and constant intensity-exercise. Revista brasileira de medicina do esporte. 2006;12(6):313-7.
  19. Hortmann K, Boutouyrie P, Locatelli JC, de Oliveira GH, Simões CF, de Souza Mendes VH, et al. Acute effects of high-intensity interval training and moderate-intensity continuous training on arterial stiffness in young obese women. European journal of preventive cardiology. 2021;28(7):e7-e10.
  20. Jones MD, Munir M, Wilkonski A, Ng K, Beynon G, Keech A. Post-exercise hypotension time-course is influenced by exercise intensity: a randomised trial comparing moderate-intensity, high-intensity, and sprint exercise. Journal of Human Hypertension. 2021;35(9):776-84.
  21. Pimenta FC, Montrezol FT, Dourado VZ, da Silva LFM, Borba GA, de Oliveira Vieira W, et al. High-intensity interval exercise promotes post-exercise hypotension of greater magnitude compared to moderate-intensity continuous exercise. European journal of applied physiology. 2019;119(5):1235-43.
  22. Rocha J, Cunha FA, Cordeiro R, Monteiro W, Pescatello LS, Farinatti P. Acute effect of a single session of pilates on blood pressure and cardiac autonomic control in middle-aged adults with hypertension. The Journal of Strength & Conditioning Research. 2020;34(1):114-23.
  23. Pescatello LS, Fargo AE, Leach Jr CN, Scherzer HH. Short-term effect of dynamic exercise on arterial blood pressure. Circulation. 1991;83(5):1557-61.
  24. Lakin R, Notarius C, Thomas S, Goodman J. Effects of moderate-intensity aerobic cycling and swim exercise on post-exertional blood pressure in healthy young untrained and triathlon-trained men and women. Clinical Science. 2013;125(12):543-53.
  25. Senitko AN, Charkoudian N, Halliwill JR. Influence of endurance exercise training status and gender on postexercise hypotension. Journal of Applied Physiology. 2002;92(6):2368-74.
  26. Green DJ, Maiorana A, O'Driscoll G, Taylor R. Effect of exercise training on endothelium‐derived nitric oxide function in humans. The Journal of physiology. 2004;561(1):1-25.
  27. Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS. The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports medicine. 2015;45(5):679-92.
  28. Shariq OA, McKenzie TJ. Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery. Gland surgery. 2020;9(1):80.
  29. Akbari A, Mohebbi H, Khalafi M, Moghaddami K. The Effect of Two Types of High Intensity and Moderate Intensity Continuous Training on Serum Levels of TNF-a and IL-10 in Obese Male Rats. Journal of Applied Health Studies in Sport Physiology. 2019;6(1):86-93. [In Persian]
  30. Hallmark R, Patrie JT, Liu Z, Gaesser GA, Barrett EJ, Weltman A. The effect of exercise intensity on endothelial function in physically inactive lean and obese adults. PloS one. 2014;9(1):e85450.
  31. Hickner R, Kemeny G, Stallings H, Manning S, McIver K. Relationship between body composition and skeletal muscle eNOS. International journal of obesity. 2006;30(2):308-12.
  32. Silva JF, Correa IC, Diniz TF, Lima PM, Santos RL, Cortes SF, et al. Obesity, inflammation, and exercise training: relative contribution of iNOS and eNOS in the modulation of vascular function in the mouse aorta. Frontiers in physiology. 2016;7:386.
  33. Elsisi HF, Albady GM, Mohammed MA, Rahmy AF. Insulin Resistance and Nitric Oxide Response to Low Volume High Intensity Interval Exercise versus Continuous Moderate Intensity Aerobic Exercise in Type 2 Diabetes Mellitus. International Journal of Therapies and Rehabilitation Research. 2016;5(1):15.
  34. Inoue K, Fujie S, Hasegawa N, Horii N, Uchida M, Iemitsu K, et al. Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity. Applied Physiology, Nutrition, and Metabolism. 2020;45(7):715-22.
  35. Peres D, Mourot L, Ménétrier A, Bouhaddi M, Degano B, Regnard J, et al. Intermittent versus constant aerobic exercise in middle-aged males: acute effects on arterial stiffness and factors influencing the changes. European Journal of Applied Physiology. 2018;118(8):1625-33.
  36. Goto C, Nishioka K, Umemura T, Jitsuiki D, Sakagutchi A, Kawamura M, et al. Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans. American Journal of Hypertension. 2007;20(8):825-30.
  37. Yan Y, Wang Z, Wang Y, Li X. Effects of acute moderate-intensity exercise at different duration on blood pressure and endothelial function in young male patients with stage 1 hypertension. Clinical and Experimental Hypertension. 2021;43(8):691-8.
  38. Moraes MR, Bacurau RF, Ramalho JD, Reis FC, Casarini DE, Chagas JR, et al. Increase in kinins on post-exercise hypotension in normotensive and hypertensive volunteers. 2007.
  39. Gorostegi-Anduaga I, Corres P, MartinezAguirre-Betolaza A, Pérez-Asenjo J, Aispuru GR, Fryer SM, et al. Effects of different aerobic exercise programmes with nutritional intervention in sedentary adults with overweight/obesity and hypertension: EXERDIET-HTA study. European journal of preventive cardiology. 2018;25(4):343-53.
  40. Jutapakdeekul W, Kulaputana O. Acute Exercise Improves Forearm Blood Flow during Postprandial Hyperglycemia in Normotensive Offspring of Hypertensive Parents. JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND. 2019;102(10):1053-9.
  41. Khalafi M, Symonds ME. The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis. Scandinavian Journal of Medicine & Science in Sports. 2020;30(11):2020-36.
  42. Fallahi A, Gaeini A, Shekarfroush S, Khoshbaten A. Cardioprotective effect of high intensity interval training and nitric oxide metabolites (NO2−, NO3−). Iranian journal of public health. 2015;44(9):1270.
  43. Khalafi M, Sakhaei MH, Rosenkranz SK, Symonds ME. Impact of concurrent training versus aerobic or resistance training on cardiorespiratory fitness and muscular strength in middle-aged to older adults: A systematic review and meta-analysis. Physiology & Behavior. 2022:113888.
  44. Chobanian AV. National High blood pressure education program committee: seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206-52.
  45. Harris RA, Padilla J, Hanlon KP, Rink LD, Wallace JP. The flow‐mediated dilation response to acute exercise in overweight active and inactive men. Obesity. 2008;16(3):578-84.
  46. Lazarova Z, Tonhajzerova I, Trunkvalterova Z, Brozmanova A, Honzikova N, Javorka K, et al. Baroreflex sensitivity is reduced in obese normotensive children and adolescents. Canadian Journal of Physiology and Pharmacology. 2009;87(7):565-71.
  47. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. The Journal of clinical investigation. 1996;97(11):2601-10.
  48. Avogaro A, de Kreutzenberg SV. Mechanisms of endothelial dysfunction in obesity. Clinica chimica acta. 2005;360(1-2):9-26.
  49. Khalafi M, Azali Alamdari K, Symonds ME, Rohani H, Sakhaei MH. A comparison of the impact of exercise training with dietary intervention versus dietary intervention alone on insulin resistance and glucose regulation in individual with overweight or obesity: a systemic review and meta-analysis. Critical Reviews in Food Science and Nutrition. 2022:1-15.
  50. Roh H-T, Cho S-Y, So W-Y. Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise. Journal of sport and health science. 2017;6(2):225-30.
  51. Parker L, Stepto NK, Shaw CS, Serpiello FR, Anderson M, Hare DL, et al. Acute high-intensity interval exercise-induced redox signaling is associated with enhanced insulin sensitivity in obese middle-aged men. Frontiers in Physiology. 2016;7:411.
  52. Esco MR, Flatt AA, Williford HN. Postexercise heart rate variability following treadmill and cycle exercise: a comparison study. Clinical Physiology and Functional Imaging. 2017;37(3):322-7.
  53. Zeigler ZS, Swan PD, Buman MP, Mookadam F, Gaesser GA, Angadi SS. Postexercise hemodynamic responses in lean and obese men. Med Sci Sports Exerc. 2018;50(11):2292-300.
  54. Tanaka S, Sugiura T, Yamashita S, Dohi Y, Kimura G, Ohte N. Differential response of central blood pressure to isometric and isotonic exercises. Scientific reports. 2014;4(1):1-5.
  55. Khalafi M, Mohebbi H, Symonds ME, Karimi P, Akbari A, Tabari E, et al. The impact of moderate-intensity continuous or high-intensity interval training on adipogenesis and browning of subcutaneous adipose tissue in obese male rats. Nutrients. 2020;12(4):925.
  56. MOHEBBI H, Khalafi M. The effect of interval and continuous training on the content of perilipin 1, ATGL and CGI-58 in visceral adipose tissue of obese male rats. Scientific Journal of Kurdistan University of Medical Sciences 2019. [In Persian]
مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 11، شماره 1
فروردین 1403
صفحه 11-22

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  • تاریخ دریافت: 26 اردیبهشت 1401
  • تاریخ بازنگری: 07 شهریور 1401
  • تاریخ پذیرش: 30 شهریور 1401

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