نقش تمرینات ورزشی با شدت متوسط و بالا در پیشگیری و درمان سرطان پستان: یک مرور سیستماتیک

نوع مقاله : مقاله مروری Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 استادیار فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم ورزشی، دانشگاه کایسر، وست پالم بیچ، آمریکا.

2 استاد فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه بیرجند، بیرجند، ایران.

چکیده

هدف: سرطان پستان یک اختلال ناشی از رشد نامنظم سلول­ها در بافت پستان است که به­طور قابل توجهی در سراسر جهان افزایش یافته است و  در حال حاضر شایع‌ترین تشخیص سرطان در زنان می­باشد. هدف از پژوهش حاضر، مروری سیستماتیک روی مطالعات انجام شده جهت بررسی تأثیر تمرینات ورزشی با شدت متوسط و بالا بر پیشگیری و درمان سرطان پستان می­باشد. روش شناسی: جستجوی مقالات مربوط به نقش تمرینات ورزشی در پیشگیری و درمان سرطان پستان و مسیرهای مولکولی درگیر در آن در پایگاه­های اطلاعاتی معتبر از جملهPub Med, Google Scholar, Scopus, SID,  وISC بین سال­های 2000 تا 2021 انجام گرفت. یافته­ها: در مطالعات مربوط به تأثیر تمرینات ورزشی در پیشگیری از سرطان پستان در افراد با خطر بالای ابتلا به سرطان پستان، نتایج نشان داد زنانی که سطح بالایی از فعالیت بدنی را دارند، 20 درصد کمتر از زنان با سطوح پایین فعالیت ورزشی به سرطان پستان مبتلا می­شوند. یافته­ها در ارتباط با تأثیر تمرینات ورزشی بر کنترل پیشرفت سرطان پستان، حاکی از آن است که تمرینات ورزشی به­طور مستقیم از طریق تأثیر روی عوامل درونی تومور و سازوکارهای مولکولی، موجب کنترل و یا بهبود سرطان پستان بدون هیچ عارضه جانبی می­شود. نتیجه­گیری: تمرینات ورزشی را می­توان به­عنوان یک مداخله مهم در پیشگیری و مکمل درمان سرطان پستان از طریق مهار تکثیر سلول­های سرطانی، القاء آپوپتوز، سرکوب آنژیوژنز، تنظیم محیط التهابی و بهبود عوارض ناشی از درمان سرطان در نظر گرفت.   

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The role of moderate and high-intensity exercise training in prevention and treatment of breast cancer: A systematic review

نویسندگان [English]

  • Fereshteh Ahmadabadi 1
  • Marziyeh Saghebjoo 2
1 Assistant professor of Exercise Physiology, Exercise and Sport Science Department, Keiser University, West Palm Beach, FL, USA
2 Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran
چکیده [English]

Aim:   Breast Cancer is a disorder caused by unregulated cell growth in breast tissue which rises significantly in worldwide and it is currently the most common cancer diagnosed in women. The aim of the present study was to explore a systemic review on the effects of moderate and high-intensity exercise training on the prevention and treatment of breast cancer. Methods: Related articles to the role of exercise training in the prevention and treatment of breast cancer and involved molecular pathways were searched from valid databases including Pub Med, Google Scholar, Scopus, SID, and ISC between 2000 to 2021 years. Results: In related studies to the effect of exercise training on breast cancer prevention in individuals at high risk for breast cancer, results demonstrated a 20% reduction in risk of breast cancer in women who have a high level of physical activity compared to sedentary women. The findings related to the effect of exercise training on controlling breast cancer progress, indicates that exercise training directly through the effect on tumor intrinsic factors and molecular mechanisms can control or improve breast cancer without any side effect.
Conclusion: Exercise training can be considered as an important intervention in the prevention and complementary treatment of breast cancer by inhibiting cancer cell proliferation, inducing apoptosis, suppressing angiogenesis, regulating the inflammation environment, and improving the side effects resulting from cancer treatment.
 

کلیدواژه‌ها [English]

  • Breast cancer
  • Apoptosis
  • Systemic inflammation
  • Angiogenesis
  • Exercise training

   

 

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 9، شماره 2
مهر 1401
صفحه 149-172

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  • تاریخ دریافت: 07 مرداد 1401
  • تاریخ بازنگری: 29 مهر 1401
  • تاریخ پذیرش: 16 آبان 1401

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