تأثیر هشت هفته تمرین هم‏زمان بر سطوح پلاسمایی NRF2 در مردان جوان

نوع مقاله : مقاله پژوهشی Released under (CC BY-NC 4.0) license I Open Access I

نویسندگان

1 استادیار فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه سمنان، سمنان، ایران.

2 استادیار فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه سمنان، سمنان، ایران

3 کارشناس ارشد فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکده علوم انسانی، دانشگاه سمنان، سمنان، ایران

چکیده

فعالیت بدنی می تواند باعث افزایش قابل ملاحظه‏ای در میزان NRF2 شود و همین امر در سالمندی منجر به کاهش القاء آنزیم‏های فسفات سدیم فاز II و حساسیت بیشتر به آسیب اکسیداتیو می‏شود. هدف پژوهش حاضر، تأثیر هشت هفته تمرین هم‏زمان بر سطوح پلاسمایی NRF2 در مردان جوان بود. در این پژوهش 16 مرد جوان تمرین نکرده (میانگین سنی 60/3±06/25 سال، وزن 21/8±37/71 کیلوگرم، BMI 52/3±09/24 کیلوگرم بر متر مربع) به‌طور تصادفی در دو گروه هشت نفری (تمرین هم‌زمان و کنترل) تقسیم شدند. برنامه تمرینی شامل هشت هفته (سه جلسه در هفته) تمرینات مقاومتی با 40 درصد یک تکرار بیشینه و تمرینات هوازی با شدت 60 درصد حداکثر ضربان قلب بود. برای اندازه‏گیری متغیرهای خونی، در شرایط ناشتا یک بار قبل و  یک بار  هم بعد از مداخله تمرینی نمونه‏گیری خونی انجام شد. نتایج نشان داد که هشت هفته تمرین هم‏زمان منجر به افزایش سطوح پلاسمایی NRF2 گردید (035/0P=) اما تفاوت معنی‏داری بعد از هشت هفته در گروه کنترل مشاهده نشد (05/0≤P). با توجه به نتایج احتمال می‏رود که افزایش سطوح NRF2 در اثر تمرین هم‏زمان، منجر به سرکوب کردن رادیکال‏های آزاد و افزایش ظرفیت ضداکسایشی بدن خواهد شد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effects of eight weeks of Concurrent Training on Plasma Levels of NRF2 in Young Men

نویسندگان [English]

  • Seyed Mohsen Avandi 1
  • Rouhollah Hagh Shenas 2
  • Solmaz Abbasi 3
1 Assistant Professor of Exercise Physiology, Department of Sport Sciences, Semnan University, Semnan, Iran.
2 Assistant Professor of Exercise Physiology, Department of Sport Sciences, Semnan University, Semnan, Iran.
3 M.Sc of Exercise Physiology, Department of Sport Sciences, Semnan University, Semnan, Iran
چکیده [English]

Physical activity can dramatically increase cellular Nrf2 level, and this factor over time is associated with aging, resulting in decreased induction of Phosphate II Phase II enzymes and increased sensitivity to oxidative damage. This study aim was to investigate the effects of eight weeks concurrent training on plasma NRF2 levels in young men. In this study, 16 young men (age: 25.06 ± 3.60 years, weight: 71.37 ± 8.21 Kg, BMI: 24.09 ± 3.52 kg.m2) were randomly divided into Concurrent training and control groups (n=8). The exercise program consisted of eight weeks (three sessions per week) of resistance training at 40% of 1RM and an aerobic exercise program with a maximum intensity of 60% of maximum heart rate. Fasting blood samples were taken prior to and after the intervention. It was found that eight weeks of concurrent training resulted in plasma NRF2 elevation (P = 0/035). However, no significant difference was observed after 8 weeks in the control group (P≤0.05). According to the results, an upregulation of NRF2 occurred during concurrent training, will lead to decrease ROS production and therefore the antioxidative capacity of the body would be elevated. 

کلیدواژه‌ها [English]

  • Oxidative ُStress
  • Concurrent Training
  • NRF2

مراجع

 
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مطالعات کاربردی تندرستی در فیزیولوژی ورزش
دوره 5، شماره 2
مهر 1397
صفحه 78-83

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سابقه مقاله

  • تاریخ دریافت: 24 شهریور 1397
  • تاریخ بازنگری: 22 فروردین 1398
  • تاریخ پذیرش: 30 اردیبهشت 1398

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