The effect of 8 weeks of intense interval training on serum CTRP12 and LCN2 levels in men with type 2 diabetes

Articles in Press

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of sport sciences, IL.c., Islamic Azad University, Ilam, Iran

2 - Department of sport sciences, IL.c., Islamic Azad University, Ilam, Iran

10.22049/jahssp.2026.30956.1787

Abstract

Background& purpose: Type 2 diabetes, which is characterized by insulin resistance and impaired insulin secretion, increases the risk of serious complications such as cardiovascular disease, renal failure, and blindness. The aim of this study was to investigate the effect of 8 weeks of high-intensity interval training on serum CTRP12 and LCN2 levels in men with type 2 diabetes. Methods: The statistical population of the present study included all middle-aged men with type 2 diabetes aged 40-50 years in Ilam city. 47 people expressed their willingness to participate through information in clubs in Ilam city. 30 of them were selected purposively and divided into two groups (15 people in each group) by simple random method: control (I), high-intensity interval training (II). The high-intensity interval training group performed 25 minutes of high-intensity interval training per session for 8 weeks (3 sessions per week). At the beginning of the study and 24-48 hours after the end of the training programs, blood samples were taken from the subjects in both groups and serum levels of CTRP12 and LCN2 were measured. Results: The results of the present study showed that high-intensity interval training significantly increased serum levels of CTRP12 compared to the control group (P=0.001). High-intensity interval training also significantly decreased serum levels of LCN2 compared to the control group (P=0.001).Conclusions: Eight weeks of high-intensity interval training increased CTRP12 levels and decreased LCN2 levels in men with type 2 diabetes. All of these indicate an improvement in metabolic status and help in the health of the individuals.

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Journal of Applied Health Studies in Sport Physiology

Articles in Press, Accepted Manuscript
Available Online from 15 June 2026

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History

  • Receive Date: 27 August 2025
  • Revise Date: 01 June 2026
  • Accept Date: 08 June 2026

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