Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license
Authors
1
Department of Exercise Physiology. Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, IRAN.
2
Department of Exercise Physiology., Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
10.22049/jahssp.2026.31123.1792
Abstract
Alzheimer's disease, a progressive neurodegenerative disorder, is characterized by the accumulation of amyloid beta and tau protein in the brain, leading to cognitive decline and neuroinflammation. The was to investigate the effect of endurance training on serum levels of amyloid beta, tau protein, and interleukin 17 in male Wistar Alzheimer's rats.
This experimental study, 24 male Wistar rats(6weeks old, weight 200 g) that were randomly divided into three groups: control (CON)(n=8), Alzheimer (ALZ)(n=8), and endurance training with Alzheimer(End+ALZ) (n=8). Alzheimer's disease was induced by intraperitoneal injection of scopolamine(1mg/kg) in the last 9 days of eight weeks of endurance training in ALZ and End+ALZ. The End+ALZ performed endurance training (treadmill running at 50–60% of maximum speed, 15–60 min) 5days a week for 8 weeks. Blood samples were collected after 40 h of fasting, centrifuged, and stored at -80°C. Serum levels of amyloid beta, tau protein, and IL-17 were measured using ELISA kits (Elabscience, BioTechne, Duoset). Data analysis was performed using SPSS version 26 software, Shapiro-Wilk test for normality, and one-way analysis of variance with LSD test at a significance level of P<0.05.
Results: ُerum amyloid beta levels, in End+ALZ compared to the ALZ decreased significantly by 38/59% (P=0.021). Tau protein and IL-17 decreased 8/49% and 0/81% respectively, but these reduction were not significant (P>0.05). Whereas, serum amyloid beta (P=0.0001), Tau protein(P=0.0001), and IL-17 (P=0.0001) levels increased significantly in ALZ compared to the CON by 285/53 % , 132.25 %, and 143/35 %, respectively. There were no significant differences between body weight, BMI, and food in CON, ALZ, and End+ALZ (P>0.05).
Conclusions: Eight-week endurance training reduced significantly serum amyloid beta levels in male Wistar rats with Alzheimer's disease and had a non-significant reducing effect on tau protein. These results support endurance training as a non-pharmacological intervention for the management of Alzheimer's disease.
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