Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license
Authors
1
Professor, Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Ira
2
Postdoctoral, Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
3
PhD, Department of Physical Education and Sport Science, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Abstract
Abstract
Aim: Parkinson's disease is a chronic neurological disorder that compromises motor and non-motor functions and leads to a decrease in the quality of life and functional capacity of individuals. Therefore, the aim of the present study was to investigate the effect of eight weeks of moderate-intensity endurance training with BCAA supplementation on the gene expression of MuRF1, Atrogin-1, and Myostatin in the soleus muscle of Parkinsonian-induced rats. Methods: In the present experimental study, 25 male Wistar rats, at 12 weeks of age and 180-200 gr were used. The rats were divided into following groups (n=5): healthy control (HC), Parkinson control (PC), Parkinson + training (PT), Parkinson + BCAA (PB), and Parkinson + training + BCAA (PTB) groups. Eight weeks of moderate-intensity endurance training (5 days a week) performed on a treadmill. One-way analysis of variance with the Tukey's post-hoc test used to analyze the data (with a significance level of P≤0.05).
Results: The results showed that after Parkinson's induction, genes expression levels of MuRF1, Atrogin-1, and Myostatin in the soleus muscle of rats significantly increased (P=0.001). There was a significant decrease in genes expression of MuRF1, Atrogin-1, and Myostatin (P=0.001) only in the moderate-intensity exercise training with BCAA supplementation group after eight weeks of interventions.
Conclusion: Although moderate-intensity endurance training and BCAA supplementation alone did not affect gene expression, combining both interventions together caused a significant change in gene expression of MuRF1, Atrogin-1, and Myostatin, indicating the significant effect of exercise when combined with BCAA supplementation for Parkinson's disease in rat.
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