The effect of eight weeks of high-intensity interval swimming training on the expression of PGC-1α and IL-6 proteins and memory function in brain hippocampus in rats with non-alcoholic steatohepatitis induced by high fat diet

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of Exercise Physiology, Faculty of Physical Education and Exercise Sciences, University of Tehran, Iran

2 Associate Professor in Exercise Physiology, Faculty of Educational Sciences and Psychology, Department of Sports Sciences, Shiraz University, Shiraz, Iran

Abstract

Aim: Nonalcoholic steatohepatitis (NASH) is the result of excessive accumulation of triglycerides in liver cells, which is associated with a decrease in PGC-1α and an increase in inflammatory cytokines. The present study was conducted with the aim of investigating the effect of eight weeks of high-intensity interval swimming training on the expression of PGC-1α and IL-6 proteins and memory function in the brain hippocampus in rats with non-alcoholic steatohepatitis induced by a high-fat diet.:. Methods: The present research was experimental. 40 male Sprague-Dawley rats were divided into two groups: healthy (n=20) and high-fat diet (HFD) (n=20). The HFD group received a high-fat diet for eight weeks with the aim of inducing the disease. After proving the disease, the rats were divided into four groups: control-healthy (n=9), training-healthy (n=9), control-disease (n=9) and training-disease (n=9). The training groups performed eight weeks of high-intensity interval swimming exercises (three sessions per week, each session lasting 30 minutes). At the end, PGC-1α and IL-6 proteins in the hippocampus of the brain were measured by ELISA method, and memory performance was evaluated by the Morris water Maze behavioral test. One-way ANOVA and Bonferroni's post hoc test were used to analyze the data (p<0.05) and all statistical methods were performed using spss version 26 software. Results: The highest and lowest amount of PGC-1α protein was observed in training-healthy and control-disease groups, respectively. Also, in the IL-6 variable, the highest and lowest levels were observed in the control-disease and training-healthy groups, respectively. There was also a significant difference between the groups in the variable of memory performance (P<0.05).Conclusion: high intensity interval swimming training in NASH can lead Increase PGC-1α and decrease IL-6 in the brain hippocampus and improve memory function.

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History

  • Receive Date: 30 April 2023
  • Revise Date: 12 July 2023
  • Accept Date: 12 July 2023

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