The effect of 12 weeks of concurrent training and capsaicin supplementation on the expression of IGF-1 and FOXO3 genes

Background& purpose: Aging is a slow and progressive process accompanied by fundamental changes in the structure of skeletal muscles. These changes include decreased muscle mass, function, and strength, causing serious challenges in the life of the elderly. This study investigated the effects of concurrent training and capsaicin administration on the expression of IGF-1 and FOXO3 genes in male aged. Methods: In this experimental study, 40 females (65Years old) were randomly assigned to four groups, namely control, capsaicin administration, concurrent training, and capsaicin administration combined with concurrent training. Concurrent trainings were performed under the standard protocol for 12 weeks. Moreover, the subjects were administered 5 mg of capsaicin supplement per kg of body weight via capsule. The research indices were measured through Real-time PCR, and the data were analyzed using a two-way analysis of variance. Results: The interaction effect of concurrent training and capsaicin consumption on FOXO3 gene expression was significant (P=0.00), and the decrease in FOXO3 gene expression was more in the combined group than the other groups and this difference was significant (P=0.00). On the other hand, capsaicin consumption and exercise increased IGF-1 gene expression (P=0.00). The increase in IGF-1 in the combined group was higher than the other groups and the difference was significant with all three groups. Conclusion: The results of the present study showed that concurrent training and capsaicin consumption led to a decrease in FOXO3 gene expression and an increase in IGF-1 gene expression, and these changes were significant in the combined group and it is recommended to follow up on nutrition and exercise strategies for greater effect.