Document Type : Review Article I Open Access I Released under (CC BY-NC 4.0) license
Authors
1
exercise physiology, maragheh University, maragheh, iran
2
PhD in Sports Biomechanics, Department of Sports Biomechanics, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
3
Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
10.22049/jahssp.2025.30567.1743
Abstract
Introduction: Adipose tissue in diabetic and obese individuals can increase pro-inflammatory markers and decrease anti-inflammatory markers; while exercise training reverses these processes and improves chronic inflammation. Therefore, the aim of the present study is to review the effect of various exercise training protocols on pro-inflammatory and anti-inflammatory adipokines in type 2 diabetic, obese, and overweight patients.
Research Method: The present study was a systematic review and meta-analysis. Articles in Persian and Latin were searched from the beginning of January 2012 to the beginning of February 2025 in the WOS, SID, Magiran, Scopus, PubMed, ISC, and Google Scholar citation databases. In this meta-analysis, the effect of exercise training on Spexin, DPP4, WISP-1, and SFRP5 levels in type 2 diabetic, obese, and overweight patients was investigated. The mean difference and 95% confidence interval (CI) were calculated using a random effects model and heterogeneity between studies was assessed using the I2 index and publication bias was assessed using the Egger test.
Results: A total of 26 studies on 5006 subjects in patients with type 2 diabetes, obesity or overweight were meta-analyzed. The results showed that combined exercises increased SFRP5 [(3.46, -0.11) 1.68] compared to the control group. Also, resistance training decreased DPP4 [(0.87, -2.57) 0.85] and WISP-1 [(2.37, -7.26) 2.44], and increased SFRP5 [(0.66, -0.95) 0.14-[ and Spexin ](5.61, -0.07) 2.77] compared to the control group. In addition, aerobic exercise decreased DPP4 [(-0.53, -4.08) 2.30] and WISP-1 [(2.80, -3.94) 0.57], and increased SFRP5 [(2.53, 0.49) 1.51] and Spexin [(2.28, 0.07) 1.17] compared to the control group.
Conclusion: The results showed that exercise training, by affecting the reduction of pro-inflammatory adipokines and the increase of anti-inflammatory adipokines, can be an effective and efficient method for improving chronic inflammation and treating metabolic diseases
Keywords
Main Subjects
)