Investigating the Synergistic Effects of Selenium Nanoparticles and High-Intensity Interval Training on Cognitive Function and BDNF Modulation in Diabetic Rats

Articles in Press

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of exercise physiology, University of Guilan, Rasht,, Iran

2 Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran

10.22049/jahssp.2025.30282.1716

Abstract

Background and Objective: Cognitive decline is a common complication of diabetes that is inadequately addressed by existing treatments. This study investigated the synergistic effects of selenium nanoparticles (SeNPs) and high-intensity interval training (HIIT) on cognitive function and neuroprotection in a diabetic rat model. Methods: Male rats (n=31) were induced with diabetes and divided into five groups: control, placebo, treatment with SeNPs (supplement), HIIT (exercise), and combined treatment of SeNPs and HIIT (supplement + excersie). Cognitive function was assessed using the Morris water maze test, and irisin receptor expression and brain-derived neurotrophic factor (BDNF) protein levels were assessed to assess neuroprotective effects. Results: The results showed that both SeNPs and HIIT significantly enhanced learning and memory and also provided neuroprotective benefits. Notably, treatment groups showed increased expression of irisin receptor in the hippocampus and increased BDNF levels compared to control groups. Conclusion: The combination of SeNPs and HIIT may effectively reduce cognitive decline and promote neuroprotection in diabetic conditions through modulation of irisin and BDNF signaling pathways.

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Journal of Applied Health Studies in Sport Physiology

Articles in Press, Accepted Manuscript
Available Online from 03 March 2025

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History

  • Receive Date: 21 January 2025
  • Revise Date: 25 February 2025
  • Accept Date: 03 March 2025

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