Effect of eight weeks of aerobic exercise with vitamin E supplementation on some markers of inflammatory and cell protection in the brain tissue of rats with Parkinson's disease

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Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Department of exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran

2 Department of exercise Physiology, shareghods Branch, Islamic Azad University, Tehran, Iran

Abstract

Aim:       Parkinson's disease is associated with an increase in inflammatory factors, a decrease in cell protection, and finally apoptosis caused by mitochondrial dysfunction. However, until now, the synergistic effect of sports activity and antioxidants on inflammatory factors and cell protection is not well known. The purpose of the present study was to investigate the effect of eight weeks of aerobic exercise with vitamin E supplementation on some markers of mitochondrial biogenesis in the brain tissue of rats with Parkinson's disease. Methods: In this experimental study, 40 Sprague-Dawley male rats (age 14-16 months and weight 250-270 grams) were given Parkinsonism with 2 mg/kg reserpine (Res) into groups (1) Res, (2) sham (Sh/soluble vitamin E), (3) AT, (4) VE and (5) AT+VE were divided. In order to investigate the effects of Res on the variables, 8 rats were included in the healthy control group (HC). Aerobic training was done for eight weeks, five sessions per week and each session lasted 48-15 minutes. VE was also taken orally at 30 mg/kg daily. To analyze the data, two-way analysis of variance and Tukey's post hoc test were used. Results: In the patient control group, HSP72 gene expression values ​​were significantly lower and NF-kb and TNF-α values ​​were significantly higher than the healthy control group (P≥0.05). Also, in the group of aerobic exercise and vitamin E supplementation, HSP72 gene expression values ​​were significantly higher and NF-κB and TNF-α values ​​were significantly lower than the patient control group (P≥0.05). However, the interaction of exercise and vitamin E supplementation did not have a significant synergistic effect on any of the gene expression values ​​of HSP72, NF-kb and TNF-α in the brain tissue of rats with Parkinson's disease (P≤0.05). Conclusion: The results of this study showed that eight weeks of aerobic exercise and vitamin E supplementation alone were effective on inflammatory markers and cell protection in brain tissue following neurodegenerative disorders; However, their interaction effect was not significant. It seems that more research is needed in the future.
 

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References

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Journal of Applied Health Studies in Sport Physiology

Articles in Press, Accepted Manuscript
Available Online from 21 January 2025

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History

  • Receive Date: 04 December 2024
  • Revise Date: 20 January 2025
  • Accept Date: 21 January 2025

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