The Effect of Functional Exercises with Two Different Intensities, and Yarrow Supplementation on Some Antioxidant and Inflammatory Indices in Individuals with Metabolic Syndrome

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Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 Master's degree, Sports Physiology Department, Faculty of Sports Sciences, Gilan of University, Rasht, Iran

2 Department of exercise physiology, University of Guilan, Rasht, IRAN

3 Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran

4 Master's degree, Department of Exercise Physiology, Faculty of Sports Sciences, Gilan University, Rasht, Iran

Abstract

Aim: Metabolic syndrome is related to an increase in free radicals and oxidative stress or a decrease in the antioxidant capacity of the body. The aim of the present study was to investigate and evaluate the effects of functional exercises with two different intensities, both with and without yarrow supplementation, on certain antioxidant and inflammatory indices in individuals with metabolic syndrome. Methods: 50 inactive obese men with metabolic syndrome were randomly divided into five groups (HIFT, FT, HIFT-S, FT-S and Control). Measurements were recorded in the health center of Mohaghegh Ardabili University. GPX, SOD, CRP, and adiponectin indices were measured in two phases before and after the exercises. The supplement group consumed 200 cc of yarrow supplement, and the control group received the placebo as a mixture of water and sugar. HIFT training protocol was performed for 6 weeks and 3 sessions for 60 minutes each week. Two-way analysis of variance with repeated measurements and to check the normality of the data, the Shapiro-Wilk test was used at the 0.05 level. Results: The results of the statistical tests did not show a significant difference between the research groups in the GPX variable (P=0.390), but the levels of SOD, CRP, and adiponectin showed a significant difference between the FT and HIFT groups and the FT-S and HIFT-S groups (P=0.001). Conclusions: These findings suggest that functional training, particularly when combined with yarrow supplementation, can enhance antioxidant capacity and reduce inflammation in individuals with metabolic syndrome. However, further research is needed to better understand the specific mechanisms and long-term benefits of these interventions.

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Main Subjects

References

  1. Goldenberg R, Punthakee Z. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Canadian journal of diabetes. 2013;37:S8-S11.
  2. Bryan S, Baregzay B, Spicer D, Singal PK, Khaper N. Redox-inflammatory synergy in the metabolic syndrome. Canadian journal of physiology and pharmacology. 2013;91(1):22-30.
  3. Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: a randomized controlled trial and an updated meta-analysis. Clinical nutrition. 2015;34(6):1101-8.
  4. Masenga SK, Kabwe LS, Chakulya M, Kirabo A. Mechanisms of oxidative stress in metabolic syndrome. International journal of molecular sciences. 2023;24(9):7898.
  5. Ozougwu JC. The role of reactive oxygen species and antioxidants in oxidative stress. International Journal of Research. 2016;1(8):1-8.
  6. Bonomini F, Rodella LF, Rezzani R. Metabolic syndrome, aging and involvement of oxidative stress. Aging and disease. 2015;6(2):109.
  7. Reljic D, Dieterich W, Herrmann HJ, Neurath MF, Zopf Y. “HIIT the Inflammation”: Comparative effects of low-volume interval training and resistance exercises on inflammatory indices in obese metabolic syndrome patients undergoing caloric restriction. Nutrients. 2022;14(10):1996.
  8. Bhol NK, Bhanjadeo MM, Singh AK, Dash UC, Ojha RR, Majhi S, et al. The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds. Biomedicine & Pharmacotherapy. 2024;178:117177.
  9. Naha PC, Davoren M, Lyng FM, Byrne HJ. Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A. 1 cells. Toxicology and applied pharmacology. 2010;246(1-2):91-9.
  10. Abd El-Kader SM, Gari A, El-Den AS. Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: a randomized clinical trial. African Health Sciences. 2013;13(4):857-63.
  11. Heinrich KM, Becker C, Carlisle T, Gilmore K, Hauser J, Frye J, Harms C. High‐intensity functional training improves functional movement and body composition among cancer survivors: a pilot study. European journal of cancer care. 2015;24(6):812-7.
  12. Heinrich KM, Spencer V, Fehl N, Carlos Poston WS. Mission essential fitness: comparison of functional circuit training to traditional Army physical training for active duty military. Military medicine. 2012;177(10):1125-30.
  13. Murawska-Cialowicz E, Wojna J, Zuwala-Jagiello J. Crossfit training changes brain-derived neurotrophic factor and irisin levels at rest, after wingate and progressive tests, and improves aerobic capacity and body composition of young physically active men and women. J Physiol Pharmacol. 2015;66(6):811-21.
  14. Ryan Shuda M, Feito Y. Challenge, commitment, community, and empowerment: Factors that promote the adoption of CrossFit as a training program. Transformation. 2017;1:1-14.
  15. Dominski FH, Serafim TT, Siqueira TC, Andrade A. Psychological variables of CrossFit participants: a systematic review. Sport sciences for health. 2021;17:21-41.
  16. Cid-Calfucura I, Herrera-Valenzuela T, Franchini E, Falco C, Alvial-Moscoso J, Pardo-Tamayo C, et al. Effects of strength training on physical fitness of olympic combat sports athletes: a systematic review. International journal of environmental research and public health. 2023;20(4):3516.
  17. Hovsepian A, Esfarjani F, Bambaeichi E, Zolaktaf V. The effect of high intensity functional training on the oxidative status, muscle damage and performance of basketball players. The Journal of sports medicine and physical fitness. 2021;61(2):188-98.
  18. Falk Neto JH, Kennedy MD. The multimodal nature of high-intensity functional training: potential applications to improve sport performance. Sports. 2019;7(2):33.
  19. Posnakidis G, Aphamis G, Giannaki CD, Mougios V, Aristotelous P, Samoutis G, Bogdanis GC. High-intensity functional training improves cardiorespiratory fitness and neuromuscular performance without inflammation or muscle damage. The Journal of Strength & Conditioning Research. 2022;36(3):615-23.
  20. Santiago DDC, Lopes JSS, Neto AMdM, Andrade CMB. Analysis of Biomarkers in Response to High Intensity Functional Training (HIFT) and High Intensity Interval Training (HIIT): A Systematic Review Study. Archives of Current Research International. 2021;21(3):59-72.
  21. Posnakidis G, Aphamis G, Giannaki CD, Mougios V, Aristotelous P, Samoutis G, Bogdanis GC. High-intensity functional training improves cardiorespiratory fitness and neuromuscular performance without inflammation or muscle damage. Journal of Strength and Conditioning Research. 2022;36(3):615-23.
  22. Farhadi H, Rahimi Fardin S, Baghaiee B. The effect of 8 week of pomegranate supplementation on inflammatory and muscular damage indices in over weight untrained men due todifferent intensity VO2max. Journal of Practical Studies of Biosciences in Sport. 2017;5(9):31-41.
  23. Rabiei Z, Bigdeli M, Lorigooini Z. A review of medicinal herbs with antioxidant properties in the treatment‎ of cerebral ischemia and reperfusion. Journal of Babol University of Medical Sciences. 2015;17(12):47-56.
  24. Verma RS, Joshi N, Padalia RC, Goswami P, Singh VR, Chauhan A, et al. Chemical composition and allelopathic, antibacterial, antifungal and in vitro acetylcholinesterase inhibitory activities of yarrow (Achillea millefolium L.) native to India. Industrial Crops and Products. 2017;104:144-55.
  25. Chávez-Silva F, Cerón-Romero L, Arias-Durán L, Navarrete-Vázquez G, Almanza-Pérez J, Román-Ramos R, et al. Antidiabetic effect of Achillea millefollium through multitarget interactions: α-glucosidases inhibition, insulin sensitization and insulin secretagogue activities. Journal of ethnopharmacology. 2018;212:1-7.
  26. Baggio CH, Otofuji GdM, Freitas CS, Mayer B, Marques MCA, Mesia-Vela S. Modulation of antioxidant systems by subchronic exposure to the aqueous extract of leaves from Achillea millefolium L. in rats. Natural product research. 2016;30(5):613-5.
  27. Judzentiene A. Atypical chemical profiles of wild yarrow (Achillea millefolium L.) essential oils. Records of Natural Products. 2016;10(2):262.
  28. Trumbeckaite S, Benetis R, Bumblauskiene L, Burdulis D, Janulis V, Toleikis A, et al. Achillea millefolium L. sl herb extract: Antioxidant activity and effect on the rat heart mitochondrial functions. Food Chemistry. 2011;127(4):1540-8.
  29. Alamdari KA, Khalafi M, Ghorbanian B. Effect of aerobic training on serum adiponectin and Ctrp-3 in males with metabolic syndrome. Iranian Journal of Endocrinology and Metabolism. 2017;18(5):Pe368-Pe77, En99.
  30. kalhor m, yuseflo s, kaveii b, mohammadi f, javadi h. Effect of Yarrow (Achillea millefolium L.) Extract on Premenstrual Syndrome in Female Students Living in Dormitory of Qazvin University of Medical Sciences. Journal of Medicinal Plants. 2019;18(72):52-63.
  31. Heinrich KM, Patel PM, O’Neal JL, Heinrich BS. High-intensity compared to moderate-intensity training for exercise initiation, enjoyment, adherence, and intentions: an intervention study. BMC public health. 2014;14(1):1-6.
  32. Abbasi H, Alizadeh M, Daneshmandi H, Barati A. Comparing the Effect of Functional, Extra-Functional and Combined Exercises on Dynamic Balance in Athletes with Functional Ankle Instability. 2015.
  33. Niknam A, Gaeini A, Hamidvand A, Jahromi MK, Oviedo GR, Kordi M, Safarpour F. High-intensity functional training modulates oxidative stress and improves physical performance in adolescent male soccer players: A randomized controlled trial. 2023.
  34. Sadowska-Krępa E, Domaszewski P, Pokora I, Żebrowska A, Gdańska A, Podgórski T. Effects of medium-term green tea extract supplementation combined with CrossFit workout on blood antioxidant status and serum brain-derived neurotrophic factor in young men: A pilot study. Journal of the International Society of Sports Nutrition. 2019;16(1):13.
  35. Kliszczewicz BM. Oxidative Stress and Heart Rate Variability Following an Accute Bout of CrossFit: Auburn University; 2014.
  36. Rios M, Macan T, Stevanović-Silva J, Nhusawi K, Fernandes RJ, Beleza J, et al. Acute CrossFit® workout session impacts blood redox marker modulation. Physiologia. 2021;1(1):13-21.
  37. Heavens KR, Szivak TK, Hooper DR, Dunn-Lewis C, Comstock BA, Flanagan SD, et al. The effects of high intensity short rest resistance exercise on muscle damage markers in men and women. The Journal of Strength & Conditioning Research. 2014;28(4):1041-9.
  38. Mangine GT, Stratton MT, Almeda CG, Roberts MD, Esmat TA, VanDusseldorp TA, Feito Y. Physiological differences between advanced CrossFit athletes, recreational CrossFit participants, and physically-active adults. PLoS One. 2020;15(4):e0223548.
  39. Cadegiani FA, Kater CE, Gazola M. Clinical and biochemical characteristics of high-intensity functional training (HIFT) and overtraining syndrome: findings from the EROS study (The EROS-HIFT). Journal of sports sciences. 2019;37(11):1296-307.
  40. Slattery K, Bentley D, Coutts AJ. The role of oxidative, inflammatory and neuroendocrinological systems during exercise stress in athletes: implications of antioxidant supplementation on physiological adaptation during intensified physical training. Sports Medicine. 2015;45:453-71.
  41. Radak Z, Taylor AW, Ohno H, Goto S. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exercise immunology review. 2001;7:90-107.
  42. Bogdanis G, Stavrinou P, Fatouros I, Philippou A, Chatzinikolaou A, Draganidis D, et al. Short-term high-intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans. Food and Chemical Toxicology. 2013;61:171-7.
  43. Li F-H, Sun L, Zhu M, Li T, Gao H-E, Wu D-S, et al. Beneficial alterations in body composition, physical performance, oxidative stress, inflammatory markers, and adipocytokines induced by long-term high-intensity interval training in an aged rat model. Experimental gerontology. 2018;113:150-62.
  44. Karstoft K, Clark MA, Jakobsen I, Müller IA, Pedersen BK, Solomon TP, Ried-Larsen M. The effects of 2 weeks of interval vs continuous walking training on glycaemic control and whole-body oxidative stress in individuals with type 2 diabetes: a controlled, randomised, crossover trial. Diabetologia. 2017;60:508-17.
  45. Mohebbi H. The Comparison of 12 Weeks Continuous Training at Fatmax and Anaerobic Threshold Intensities and High Intensity Interval Training on Antioxidant Enzymes and Lipid Peroxidation Index in Pre-diabetic Patients. Medical Journal of Tabriz University of Medical Sciences. 2020;42(2):168-76.
  46. Hameed I, Masoodi SR, Mir SA, Nabi M, Ghazanfar K, Ganai BA. Type 2 diabetes mellitus: from a metabolic disorder to an inflammatory condition. World journal of diabetes. 2015;6(4):598.
  47. Martemucci G, Fracchiolla G, Muraglia M, Tardugno R, Dibenedetto RS, D’Alessandro AG. Metabolic syndrome: a narrative review from the oxidative stress to the management of related diseases. Antioxidants. 2023;12(12):2091.
  48. Yu Z, Ye X, Wang J, Qi Q, Franco OH, Rennie KL, et al. Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people. Circulation. 2009;119(23):2969-77.
  49. Saidei P, Mohebbi H, Rahmaninia F, Mohammad ghasemi F. The effects of high fat diet and negative energy balance methods on adipocyte size and concentrations of adiponectin in fat depots of abdominal cavity in obese rats. Metabolism and Exercise. 2015;4(2):89-108.[ In Persian].
  50. Nicklas BJ, You T, Pahor M. Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. Cmaj. 2005;172(9):1199-209.
  51. Dekker MJ, Lee S, Hudson R, Kilpatrick K, Graham TE, Ross R, Robinson LE. An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism. 2007;56(3):332-8.
  52. Campbell KL, Campbell PT, Ulrich CM, Wener M, Alfano CM, Foster-Schubert K, et al. No reduction in C-reactive protein following a 12-month randomized controlled trial of exercise in men and women. Cancer Epidemiology Biomarkers & Prevention. 2008;17(7):1714-8.
  53. Kelley GA, Kelley KS. Effects of aerobic exercise on C-reactive protein, body composition, and maximum oxygen consumption in adults: a meta-analysis of randomized controlled trials. Metabolism. 2006;55(11):1500-7.
  54. Milani RV, Lavie CJ, Mehra MR. Reduction in C-reactive protein through cardiac rehabilitation and exercise training. Journal of the American College of Cardiology. 2004;43(6):1056-61.
  55. Kadoglou NP, Iliadis F, Angelopoulou N, Perrea D, Ampatzidis G, Liapis CD, Alevizos M. The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. European Journal of Preventive Cardiology. 2007;14(6):837-43.
  56. Okita K, Nishijima H, Murakami T, Nagai T, Morita N, Yonezawa K, et al. Can exercise training with weight loss lower serum C-reactive protein levels? Arteriosclerosis, thrombosis, and vascular biology. 2004;24(10):1868-73.
  57. Oberbach A, Tönjes A, Klöting N, Fasshauer M, Kratzsch J, Busse MW, et al. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. European journal of endocrinology. 2006;154(4):577-85.
  58. Li Y, Tan Q, Guo Y, Wang Q, Ding L, Li H, Zeng H. The Influence of Exercise Training on Endothelial Function, Serum Irisin and Inflammatory Markers in the Elderly with Metabolic Syndrome. Clinical Laboratory. 2021(3).
  59. Nazarabadi PN, Etemad Z, Hoseini R, Moradi F. Anti-Inflammatory effects of a period of aerobic training and vitamin D supplementation in postmenopausal women with metabolic syndrome. International Journal of Preventive Medicine. 2022;13(1):60.
  60. Tay J, Goss A, Locher J, Ard J, Gower B. Physical function and strength in relation to inflammation in older adults with obesity and increased cardiometabolic risk. The Journal of nutrition, health and aging. 2019;23(10):949-57.
  61. Kirzinger B, Stroux A, Rackoll T, Endres M, Flöel A, Ebinger M, Nave AH. Elevated serum inflammatory markers in subacute stroke are associated with clinical outcome but not modified by aerobic fitness training: results of the randomized controlled PHYS-STROKE trial. Frontiers in neurology. 2021;12:713018.
  62. As' ad MRaF, Liben P, Herawati L. Mechanism of Physical Exercise on Lowering Levels of C-Reactive Protein (CRP) in Overweight and Obese. Folia Medica Indonesiana. 2021;57(1):82-9.
  63. Tekieh E, Rezazadeh S, Manaheji H, Akbari A, Zaringhalam J. The Effects of Pretreatment with Achillea santolina and Stachys athorecalyx Extracts on CFA-induced acute inflammation in male rats. Journal of Medicinal Plants. 2010;9(34):165-76.
  64. Okunrobo L, Usifoh C, Ching P. Anti-inflammatory evaluation of methanol extract and aqueous fraction of the leaves of Anthocleista djalonensis A. 2009.
  65. AHMADI DA, Gholami AM, Faghani M, Ansari CS, Saafizadeh Z. Comparison of essential oil of Achillea millefolium with chemical antioxidants and preservatives. 2019.
  66. Nickavar B, Kamalinejad M, Haj-Yahya M, Shafaghi B. Comparison of the free radical scavenging activity of six Iranian Achillea. species. Pharmaceutical biology. 2006;44(3):208-12.
  67. Ardestani A, Yazdanparast R. Antioxidant and free radical scavenging potential of Achillea santolina extracts. Food chemistry. 2007;104(1):21-9.
Journal of Applied Health Studies in Sport Physiology

Articles in Press, Accepted Manuscript
Available Online from 07 December 2024

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  • Receive Date: 04 August 2024
  • Revise Date: 07 December 2024
  • Accept Date: 07 December 2024

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