The effect of 8-weeks of high intensity interval training (HIIT) along with L-cysteine consumption on the level of NLRP3 in the heart tissue of rats with type 2 diabetes

Articles in Press

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 university of mohaghegh ardabili

2 Associate Professor of Sport Physiology, University of Mohaghegh Ardabili

3 Department of Physical Education & Sport Science, University of Mohaghegh Ardabili, Ardabil, Iran

4 Assistant Professor of Sports Physiology, Islamic Azad University, Jolfa Branch

Abstract

Aim: NLRP3 inflammasome activation has a role in pathological processes and disorders, including obesity and type 2 diabetes, and is related to the pathophysiology of cardiovascular diseases, including heart failure and myocardial ischemia. The aim of this study is to investigate the effect of eight weeks of high-intensity interval training along with L-cysteine consumption on the level of NLRP3 in the heart tissue of rats with type 2 diabetes. Methods: In this study, 30 male Wistar rats were divided into five control groups (healthy control, diabetic control) and experimental (diabetic-exercise, Diabetic-L-cysteine supplementation, and Diabetic-L-cysteine supplementation and exercise). After inducing diabetes to experimental and diabetic control groups, the exercise group performed intense interval training for eight weeks. L-cysteine supplement group also took 200 mg tablets dissolved in 3 ml of water for eight weeks. To determine the difference between the groups, one-way analysis of variance and post hoc Bonferroni test were used. Results: Compared to the diabetic control group, all three experimental groups showed a significant decrease in NLRP3 index (p≥0.01). In the comparison of two experimental groups included intense Interval Training with and without L-cysteine supplementation, no significant difference was observed in the decreasing changes of NLRP3 index (p≤0.05). Also, in the comparison of the two experimental groups included intense Interval Training and l-cysteine supplement and single l-cysteine consumption, the intense interval training and l-cysteine supplement group had more and significant decreasing changes in the NLRP3 index in rats with type 2 diabetes. (p≥0.01). Conclusions: The implementation of high-intensity interval training without L-cysteine consumption has a greater effect on the significant reduction of NLRP3 in the heart tissue of rats with type 2 diabetes.

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Journal of Applied Health Studies in Sport Physiology

Articles in Press, Accepted Manuscript
Available Online from 14 September 2024

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History

  • Receive Date: 15 July 2024
  • Revise Date: 24 August 2024
  • Accept Date: 14 September 2024

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