The effect of eight weeks of endurance training and alkaline consumption on inflammatory biomarkers and oxidative stress in obese men with metabolic syndrome

Aim: Nowadays, the intervention of physical exercises along with sports nutrition is considered as an effective treatment method in modulating inflammatory and oxidative responses in obese people with metabolic syndrome. Therefore, the aim of this research is to investigate the effect of eight weeks of endurance training and alkaline consumption on interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), nitric oxide (NO) and total thiol (T-SH) in Obese men with metabolic syndrome. Methods: The current research was a semi-experimental one-blind type. For this purpose, 56 men (average age= 33.27±3.11 years, average weight= 94.16±2.91 kg and BMI= 32.56±1.32 kg/m2) voluntarily participated in this research. Subjects were randomly divided into four groups: endurance training, endurance training with alkaline water, alkaline water and control. The training intervention was implemented three sessions a week for eight weeks. Alkaline water (pH 9.5) was received at the rate of 10 kg/mL after each training session. Blood samples were taken before training and 48 hours after the last training session to measure inflammatory biomarkers and oxidative stress. Results: The results showed that the values of IL-6 and TNF-α in the group of endurance training with alkaline water and endurance training compared to the groups of alkaline water and control had a significant decrease, and the values of NO and T-SH had a significant increase (p<0.05). The highest percentage of significant changes in the values of IL-6, TNF-α, NO and T-SH were assigned to the training group with alkaline water. Alkaline water alone did not cause significant changes (P>0.05). Conclusions: Therefore, the combined effect of endurance exercise and alkaline water improves inflammatory responses and oxidative stress in obese men with metabolic syndrome.