The effect of resistance training on the expression of PGC1a, SIRT1 and SREBP1 genes in liver tissue of obese Vistar rats

Document Type : Research Paper I Open Access I Released under (CC BY-NC 4.0) license

Authors

1 department of physical education and sport science, bojnourd branch, islamic azad university, bojnourd, iran

2 Department of Physical Education, Isalmic Azad University, Bojnourd branch, Bojnourd, Iran

Abstract

Aim:      Studies have shown that the consumption of omega-3 and vitamin E can have anti-inflammatory and antioxidant effects, and the use of these supplements is suggested in situations where muscle damage and inflammation occurs following exercise activities. The aim of this study was to determine the effect of short-term consumption of omega-3 and vitamin E supplements on some indices of collagen breakdown (hydroxylysine and serum hydroxyproline) and muscle damage (lactate dehydrogenase, creatine kinase) in untrained young people. Materials and methods:   Eight healthy and non-active men (age: 21.33±2.12 years, fat percentage: 19.02±4.46) were selected using statistical methods to determine the sample size. Subjects were randomly divided into two conditions of supplement and placebo. The research design was carried out in a blind way and the subjects did not know about the content of the supplement packages until the end of the research protocol. At the time of taking supplements, they took 3000 mg of omega-3 supplement in three meals daily (1000 mg each) and 400 IU of vitamin E supplement in one meal. Soft gels containing oral paraffin were consumed as a placebo. On the eighth day, for both conditions of the research, the subjects had a bout of intense anaerobic activity, including 8 sets of 12 repetitions of pair jumping on the box and 8 sets of 12 repetitions of landing from the 43 cm box with a one-minute rest between each set. Before supplementing and 24 and 48 hours after performing anaerobic activity, blood samples tests were taken from the subjects. Result:  The results showed that the values of lactate dehydrogenase (p=0.033) and hydroxyproline (p=0.046) increased significantly in 48 hours after anaerobic exercise compared to baseline. No significant change was observed in the values of creatine kinase (p=0.083) and hydroxylysine (p=0.088) variables. Conclusion: According to the findings, it seems that the combined consumption of omega-3 and vitamin E could not have a protective role on some indicators related to cell membrane and collagen damage, although more studies are needed for a more accurate conclusion.

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References

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Journal of Applied Health Studies in Sport Physiology
Volume 11, Issue 2
August 2024
Pages 106-117

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History

  • Receive Date: 19 February 2024
  • Revise Date: 14 May 2024
  • Accept Date: 14 May 2024

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